Part I. INTRODUCTION
1. Mileposts in Nuclear Medicine History
2. Decision Making, Statistics, and Informatics
3. Radiation Safety

Part II. The Scientific Basis of Nuclear Medicine
A. PHYSICS
4. The scientific basics of nuclear medicine
5. Gas-filled ionization radiation detectors in nuclear medicine
6. Scintillation detectors and scintillation detector counting systems
7. Gamma camera imaging systems
8. Collimator characteristics and design
9. Nuclear counting statistics
10. Progress in semiconductor detectors for use in nuclear medicine
11. Representation of gamma camera images by computer
12. Image content and image filtering techniques
13. In vivo quantitation of activity by planar imaging
14. SPECT Image Reconstruction
15. Gamma camera SPECT systems and quality control
16. Nuclear Medicine image display techniques
17. Quantitative SPECT
18. A quality control program for nuclear medicine cameras
19. Principles of PET/CT imaging and imaging systems
20. PET image reconstruction and attenuation correction techniques
21. Tracer kinetics: principles of compartmental analysis and physiologic modeling
22. Internal radiation dosimetry
B. RADIOPHARMACY
23. Principles of radiopharmacy
24. Pathway for FDA approval of new radiopharmaceuticals
25. Radionuclides: cyclotron, reactor, and fission products
26. Radionuclide generators: design, operation, and clinical utility
27. The chemistry of technetium and other metals as it applies to radiopharmaceuticals
28. Radiopharmaceutical chemistry: iodination techniques
29. Radiolabeling formed elements of blood: methods and mechanisms (cell labeling)
30. Quality control in the hot lab
31. Assuring microbiological purity of Radiopharmaceuticals
32. Positron radiopharmaceutical agents and their chemistry
33. In vivo non-imaging studies
34. Principles and applications of radioassays
35. Adverse reactions to radiopharmaceutical agents
36. Basic principles of radiation biology
37. Planning for radiation accidents and radiological events

Part III. Immunologic Aspects of Nuclear Medicine
38. New approaches to radiolabeling monoclonal antibodies
39. Tumor necrosis therapy of cancer: new methods of antibody targeting
40. Radiation dosimetry of radiolabeled monoclonal antibodies: practical considerations
41. Overview of imaging procedures with radiolabeled monoclonal antibodies in cancer patients

Part IV. Clinical Organ Systems Studies
A. CARDIOVASCULAR
42. Radiopharmaceutical agents for cardiac imaging
43. Computer aspects of myocardial imaging
44. Functional cardiac imaging
45. Clinical applications of myocardial perfusion imaging
46. Radiopharmaceuticals for myocardial infarct imaging
47. MIBG imaging
48. Positron Emission Tomography of the Cardiovascular System
49. Peripheral vascular disease: arterial and venous
B. ENDOCRINE
50. The thyroid gland
51. Scintigraphic imaging of the adrenals and neuroectodermal tumors
52. Parathyroid scintigraphy
53. Correlative endocrine imaging
VOLUME II

C. GASTROINTESTINAL
54. Radiopharmacy aspects of gastrointestinal imaging
55. Salivary glands
56. Esophageal transit and reflux gastric emptying
57. Radiopharmaceuticals for liver and spleen imaging
58. Liver and spleen imaging
59. Radiopharmaceuticals for hepatobiliary imaging
60. Hepatobiliary imaging
61. Evaluating gastrointestinal bleeding by nuclear medicine techniques
62. Scintigraphic assessment of peritoneovenous shunt function
D. Genitourinary
63. Radiopharmaceuticals for renal imaging
64. Glomerular Filtration
65. The role of ACE inhibitor renography in the diagnosis of renovascular hypertension
66. Evaluation of renal transplants
67. Testicular imaging
68. Pediatric Urology

E. Musculoskeletal
69. Bone Imaging Radiopharmaceuticals
70. Skeletal scintigraphy in non-neoplastic osseous disorders
71. Malignant bone disease
72. Bone marrow scintigraphy
73. Measurement and interpretation on bone mineral density
F. Neurology
74. Radiopharmaceuticals for cerebral imaging
75. Cerebral perfusion imaging
76. Cerebrospinal fluid imaging
77. The role of positron emission tomography in the investigation of neurological disorders
78. The role of positron emission tomography in the investigation of psychiatric disorders
79. Correlative imaging in neurology and neurosurgery
G. Pulmonary
80. Radiopharmaceuticals for pulmonary imaging
81. Ventilation/perfusion scintigraphy
82. Pulmonary imaging for nonthrombolic disease
Part. V Special Oncologic Studies
83. Non PET Oncologic Imaging
84. Lymphoscintigraphy in oncology
85. Positron emission tomography: applications in oncology
Part VI. Correlative Imaging
86. Prospective Image Fusion: the role of SPECT/CT and PET/CT
87. Retrospective merging of physiological and anatomical images: software solutions
88. The future of nuclear medicine: molecular imaging and radiotherapy

Part VII. Therapy with unsealed sources
89. Therapy of hyperthyroidism
90. The treatment of thyroid malignancies
91. Radionuclide therapy in the peritoneum, pleura, synovium, and hematopoietic system
92. Radionuclide Synovectomy
93. Therapy for painful skeletal metastases
94. Radioimmunotherapy of lymphomas and leukemias
95. Radioimmunotherapy of solid tumors
96. Radioimmunotherapy with alpha-emitting radionuclides
Part VIII. Diagnosis of inflammatory disease
97. Gallium imaging
98. Indium-111 labelled leukocyte imaging in the diagnosis of infection and inflammatory disease
99. Imaging inflammation and infection TC 99m HMPAO labeled leukocytes
100. Infection imaging using labeled antibodies and newer agents
101. Correlative imaging of abdominal infection
Part IX. Pediatrics
102. Radiopharmaceuticals for pediatric imaging
103. Pediatric skeletal scintigraphy
Index