Oncology: An Evidence-Based Approach is a textbook designed to reflect the principles and current practice of oncology with contributors from the fields of medical, surgical, and radiation oncology. The textbook will incorporate an evidence-based approach, enabling the reader to make decisions on the basis of concrete data. Sections on solid tumors, hematologic malignancies and the practice of oncology address the natural history and therapy for the full spectrum of neoplastic diseases in the adult. Further sections present fundamentals of supportive care of the cancer patient, the management of oncologic emergencies and acute toxicities of therapy, as well as care of metastatic disease and the terminally-ill patient. Breaking new ground, the textbook features thoughtful, in-depth sections on cancer prevention and control, cancer surviorship, the economics of cancer care, and cancer informatics. Cancer imaging is covered with an organ system-based approach, with an additional chapter on the especially intriguing potential of PET. Furthermore, a comprehensive section on translational basic science reviews the fundamentals of molecular biology, the cell cycle and signal transduction, carcinogenesis, cancer genetics, the biology of invations and metastasis, and tumor.

Table of contents


Section I. Principles of Oncology * Evidence-Based Approach to Oncology * Principles of Chemotherapy * Principles of Radiation Oncology * Principles of Surgical Therapy in Oncology * Principles of Targeted and Biological Therapies * Biologic Principles of Hematopoietic Stem Cell Transplantation * Evaluation of Tumor Markers: An Evidence-Based Guide for Determination of Clinical Utility * Design and Analysis of Oncology Clinical Trials * Ethics of Clinical Oncology Research * Informatics Infrastructure for Evidence-Based Cancer Medicine * Economics of Cancer Care * Principles of Screening for Cancer * Patient Decision Making * Establishing an Interdisciplinary Oncology Team * Principles of Complementary and Alternative Medicine for Cancer * Section II. Translational Basic Science * Fundamental Aspects of the Cell Cycle and Signal Transduction * Viral Carcinogenesis * Environmental Carcinogenesis * Cancer Metastasis * Tumor Immunology and Immunotherapy * Technologies in Molecular Biology: Diagnostic Applications * Section III. Cancer Prevention and Control * Cancer Epidemiology * Evidence-Based Cancer Prevention Research: A Multidisciplinary Perspective on Cancer Prevention Trials * Screening * Genetic Screening and Counseling for High-Risk Populations * Behavior Modification * Section IV. Cancer Imaging * Central Nervous System Imaging * Chapter 28. Breast Imaging * Imaging of Thoracic Malignancies * Imaging of Gastrointestinal Stromal Tumor * Genitourinary Imaging * Musculoskeletal Imaging * PET * Section V. Solid Tumors * Central Nervous System Tumors * Eye, Orbit, and Adnexal Structures * Head and Neck Cancer * Lung * Therapy for Malignant Pleural Mesothelioma * Mediastinum * Esophageal Cancer * Stomach * Colon, Rectal and Anal Cancer Management * Adenocarcinoma and Other Small Intestinal Malignancies * Cancer of the Liver and Bile Ducts * An Evidence-Based Approach to the Management of Pancreatic Cancer * Renal Cell Cancer * Ureter, Bladder, Penis, and Urethra * Prostate Cancer * Testis Cancer * Cervix, Vulva, and Vagina * Gestational Trophoblastic Neoplasia * Ovarian Cancer * Uterine Malignancies * Evidence-Based Management of Breast Cancer * Thyroid and Parathyroid * Tumors of the Endocrine System * Sarcomas of Bone * Soft Tissue Sarcoma * Cutaneous Melanoma * Nonmelanoma Cutaneous Malignancies * Cancer of Unknown Primary Site * Solid Tumors of Childhood * Section VI. Hematologic Malignancies * Acute Myeloid Leukemia and the Myelodysplastic Syndromes * Acute Lymphoblastic Leukemia * Chronic Lymphocytic Leukemia and Related Chronic Leukemias * Chronic Myeloid Leukemia * An Evidence-Based Approach to the Management of Hodgkin's Lymphoma * Non-Hodgkins Lymphomas * Plasma Cell Lymphomas * Section VII. Practice of Oncology Oncologic Emergencies * Superior Vena Cava Syndrome * Central Nervous System Emergencies * Metabolic Emergencies in Oncology * Surgical Emergencies * Acute Toxicities of Therapy * Oral Complications of Cancer Therapy Alopecia and Cutaneous Complications of Chemotherapy * Infectious Complications of Cancer Therapy * Acute Toxicities of Therapy: Pulmonary Complications * Cardiac Complications * Neurologic Complications of Therapy * Acute Toxicities of Therapy: Urologic Complications * Supportive Care * Management of Cancer Pain * Nausea and Vomiting in the Cancer Patient * Nutritional Support for the Cancer Patient * Paraneoplastic Syndromes * Malignant Effusions * Bone Marrow Dysfunction in the Cancer Patient (RMS) * Management of the Bone Marrow Transplant Patient * Management of Anxiety and Depression in Adult Cancer Patients: Toward an Evidence-Based Approach Reproductive Complications and Sexual Dysfunction in the Cancer Patient * The Care of the Terminal Patient * Care of Site-Specific Metastatic Disease * Metastatic Cancer to the Central Nervous System * Metastatic Cancer to Lung * Surgical and Regional Therapy for Liver Metastases * Metastatic Cancer to Bone * Care of Unique Subpopulations * Cancer in the Immunosuppressed Patient (RMS)* Cancer in the Older Population * Chemotherapy in Patients with Organ Dysfunction * Management of the Pregnant Cancer Patient * Section VIII. Cancer Survivorship * Survivorship Research: Past, Present and Future * Late Effects of Cancer Treatments * Medical and Psychosocial Issues in Childhood Cancer Survivors * Chapter 103. Medical and Psychosocial Issues in Hodgkin's Disease Survivors * Medical and Psychosocial Issues in Testicular Cancer Survivors * Medical and Psychosocial Issues in Gynecological Cancer Survivors * Medical, Psychosocial, and Health-Related Quality of Life Issues in Breast Cancer Survivors * Medical and Psychosocial Issues in Prostate Cancer Survivors * Physical and Psychosocial Issues in Lung Cancer Survivors * Cancer Survivorship Issues in Colorectal Cancer * Medical and Psychosocial Issues in Transplant Survivors * Second Malignancies after Radiation Treatment and Chemotherapy for Primary Cancers * Psychosocial Rehabilitation in Cancer Care * Cancer Advocacy