This definitive and comprehensive 2 volume text-reference book is essential reading for those who are primarily involved in the practice of nuclear medicine. Over 180 contributors, all of them internationally recognized authorities, focus on current and newly available radionuclide techniques and directly apply them to clinical practice. Covering all of the major body systems and organs in which nuclear medicine procedures are used, the book takes a disease oriented approach and this new edition features the latest advances in diagnostic and therapeutic modalities used in the detection and treatment of cancer, heart disease, neurologic disorders, trauma and other common and less common diseases. There are major revisions/ new chapters in the areas of brain imaging, movement disorders, stroke, lymphoma therapy, bone density, non-neurologic drug discovery, molecular imaging, cost/benefit analysis.

Reviews

"Destined to become one of the leading textbooks of nuclear medicine"Review of Previous Edition from New England Journal of Medicine
the most impressive and comprehensive text of its type on the market today"British Journal of Radiology
text is an outstanding addition to the field...currently unmatched in depth and quality and is well placed to become the gold standard for nuclear medicine texts"ANZ Journal of Nuclear Medicine
an important void as an up-to-date reference source"Journal of Nuclear Medicine

What's New

Expanded coverage of the sections dealing with Tumor diagnosis and therapy, Cardiac nuclear imaging and radionuclide imaging of neurologic and psychiatric disorders
New chapters on Lymphoma Therapy, PET imaging, Sentinel Lymph Node Biopsy, Gated SPECT, Multi-Modality imaging, Molecular imaging, Drug Discovery, Cost/Benefit analysis, Bone density.
Complete and thorough up-date of all chapters.
Full color images incorporated throughout the text rather than being isolated in color plate sections
Introduction of new, high visibility co-Editor-Dr Sam Gambhir (UCLA) to provide better editorial balance.

Contents
Section 1: Nuclear medicine in tumor diagnosis and therapy
Part A: Diagnosis
1. Tumor-seeking radiopharmaceuticals: nature and mechanisms
2 Radionuclide imaging of hepatic tumors
3 PET in lymphoma and malignant melanoma
4 Parathyroid imaging
5 Adrenocortical scintigraphy
6 Gallium scintigraphy in tumor diagnosis and management
7 Thallium-201 chloride: a tumor imaging agent
8 MIBG in the diagnosis of neuroendocrine tumors
9 Peptide receptor scintigraphy in oncology
10 The diagnostic role of radiolabeled antibodies in cancer
11 Cancer cell biology basis for nuclear oncology
12 Differentiated thyroid carcinoma
13 Medullary thyroid cancer
14 Breast scintigraphy
15 Pediatric tumors
16 Functional analysis of cancer therapy effects in other organs
17 The use of intraoperative probes in surgical oncology
18 The sentinel lymph node in surgical oncology
19 FDG PET Imaging of Head and Neck Cancer
20 External Beam Radiotherapy Treatment Planning with PET
21 PET in aerodigestive tumors
22 PET in gynecological tumors (breast, cervical and ovarian)
23 Nuclear medicine imaging in pediatric oncology
24 Positron Emission Tomography (PET) in genitourinary tumors: prostate, bladder, testicular and renal cancer
25 Future clinical applications of PET (amino acid and nucleoside imaging)
26 PET imaging of brain tumors
Section 1: Nuclear medicine in tumor diagnosis and therapy
Part B: Radionuclide therapy
27 Principles of radionuclide therapy
28 Dosimetric and radiobiological considerations: The MIRD concept
29 Dosimetric and radiobiological considerations: Patient-individual dosimetry
30 Radioiodine therapy of the thyroid: Treatment of benign thyroid diseases
31 Radioiodine therapy of the thyroid: Treatment of thyroid malignancies
32 Phosphorus-32 therapy in myeloproliferative disorders
33 Palliation of bone pain
34 Radioimmunotherapy of hematologic neoplasms
35 Radioimmunotherapy of solid tumors
36 MIBG therapy
37 Receptor-targeted radiopeptide therapy
38 Use of radiolipiodol in the treatment of hepatic tumours
39 Alternative approaches to targeting therapy
40 New developments: Nuclear gene therapy
41 Atlas 1: PET and PET/CT
42 Atlas 2: SPET and SPET/CT
Section 2: Nuclear medicine in disorders of bones and joints
43 Bone scintigraphy: the procedure and interpretation
44 Evaluation of primary bone tumors
45 The evaluation of malignancy: metastatic bone disease
46 Assessment of infection
47 Radionuclide assessment of the painful joint prosthesis
48 Vascular manifestations
49 Bone scintigraphy in trauma
50 Bone scintigraphy in sports medicine
51 Growth and metabolic disorders
52 Arthritis: current status of scintigraphy and future trends
53 Radiation synovectomy
Section 3: Quantitative studies of gastrointestinal function
54 Salivary gland disorders
55 Esophageal function (transport and motility)
56 Gastric motility
57 Intestines: evaluation of absorption
58 Studies of small bowel and colonic transit
59 Hepatobiliary function: biliary kinetics
60 Scintigraphic measurement of hepatic function
Section 4: Nuclear medicine in acute care
61 Nuclear cardiology and cardiac transplantation
62 Cardiovascular conditions: venous thrombosis
63 Pulmonary embolism
64 Non-embolic disease of the lungs
65 Gastrointestinal bleeding
66 Cholescintigraphy
67 Neonatal hyperbilirubinemia
68 Nuclear medicine in acute care of neurological patients
69 Radiolabeled agents for the localization of infection and inflammation
70 Undiagnosed fever
71 Inflammatory bowel disease
72 Nuclear imaging in cardiovascular infection and cardiac transplant rejection
73 The immunocompromised patient
Section 5: Nuclear cardiology
74 Radiopharmaceuticals for the study of the heart
75 Radionuclide ventriculography and the assessment of impaired ventricular function
76 Infarct avid imaging and myocardial perfusion scintigraphy techniques using single photon radiotracers
77 Cardiac positron emission tomography
78 Cardiac stress
79 The detection of coronary artery disease
80 Assessment of prognosis in patients with known or suspected coronary artery disease
81 Assessment after myocardial revascularization
82 Assessment of myocardial viability in dysfunctional myocardium
83 Myocardial infarction: the assessment of thrombolysis
84 Congenital heart disease
85 Single-photon imaging of myocardial metabolism: the role of iodine 123 fatty acids and fluorine-18 deoxyglucose
86 Clinical applications of PET
87 Myocardial innervation: imaging and quantification
88 Nuclear medicine techniques in the assessment of human thrombosis and atheroma
Section 6: Nuclear medicine in neurological and psychiatric diagnosis
89 The blood-brain barrier
90 Lipophilic tracers: the amines
91 Lipophilic tracers for the study of regional cerebral blood flow
92 Ligands for neuroreceptor imaging by positron or single photon emission tomography
93 PET tracers for brain scanning
94 Neuroactivation
95 Image analysis in brain SPECT and PET
96 SPECT brain imaging in cerebrovascular disease
97 Nuclear medicine in the management of a patient with epilepsy
98 Nuclear medicine and the management of patients with Parkinson's movement disorders
99 Anxiety disorders and affective disorders
100 Addictions
101 The management of patients with schizophrenia
102 PET and SPECT imaging in evaluating Alzheimer's disease and related dementias
103 Nuclear medicine and drug studies in the brain
104 Cerebrospinal fluid physiology, clearance flow studies and cerebrospinal fluid shunt studies
105 Atlas 3: PET brain atlas
Section 7: Nuclear medicine in renal disorders
106 Overview of renal nuclear medicine
107 Radiopharmaceuticals: their intrarenal handling and localization
108 Dynamic static renal imaging
109 Quantitative evaluation of clearance
110 Measurement and interpretation of renal transit times
111 The role of PET in renal nuclear medicine
112 Renal infection
113 Pediatric aspects of radionuclides in nephrourology
114 Nuclear medicine in the clinical diagnosis and treatment of obstructive uropathy
115 Vascular disorders, with emphasis on hypertension
116 Renal failure
117 Space-occupying lesions and trauma
118 Renal transplant evaluation
119 The genital tract
Sction 8: Basic sciences
120 Fundamental molecular/cell biology
121 Radioisotope production
122 Radiochemistry
123 Radiopharmacy
124 Basic physics and detection of radiation
125 Nuclear medicine imaging instrumentation
126 Nuclear medicine computers: Basic principles
127 Nuclear medicine computers: Applications
128 Single photon emission computed tomography (SPECT)
129 Positron emission tomography (PET)
130 Primer on molecular imaging
131 Radiation protection and dosimetry in clinical practice
132 Clinical decision making: an introductory, quantitative approach to diagnostic investigations
133 ecision analysis fundamentals