Established as the Bible of Rheumatology, this definitive two-volume reference is now in its thoroughly updated Fifteenth Edition. More than 200 of the world's preeminent experts provide encyclopedic coverage of the entire field of rheumatology, including relevant basic science, diagnostic and therapeutic modalities, and pathophysiology, diagnosis, and medical and surgical management of all rheumatic diseases and syndromes. Chapters include extensive references and more than 1,200 illustrations complement the text.A new co-editor, Dr. Larry Moreland, joins Dr. Koopman for this edition. Coverage includes numerous new treatment modalities, a new chapter on anti-TNF drugs, and cutting-edge molecular and genetic research.

FEATURES:

Encyclopedic Coverage
More than 1,200 illustrations complement the text

Extensively referenced chapters

Well known and well regarded editors

NEW TO THIS EDITION:

New co-editor
Coverage includes numerous new treatment modalities, a new chapter on anti-TNF drugs, and cutting-edge molecular and genetic research

Comprehensive review of the basic science of each rheumatologic diseases presented in the book

Contents

Section I: Introduction to the Study of the Rheumatic Diseases
1. Epidemiology of the Rheumatic Diseases, D.T. Felson
2. Differential Diagnosis of the Rheumatic Diseases: Analysis of Signs and Symptoms, D.J. McCarty
3. Clinical Evaluation in the Rheumatic Diseases, N. Bellamy
4. Analysis of Synovial Fluid, Ted Mikuls
5. Arthroscopy, K.C. Kalunian
6. Magnetic Resonance Imaging of the Joints, H.K. Genant

Section II: Scientific Basis for the Study of the Rheumatic Diseases
7. Structure and Function of Joints, Paul Wooley
8. Synovial Physiology, P. A. Simkin
9. Collagen Structure & Function, Richard Mayne
10. Structure, Function and Metabolism of Cartilage Proteoglycans, Anne Woods
11. Cartilage Structure and Function, A.Robin Poole
12. Structure and Function of Synoviocytes, Steffen Gay
13. Immunoglobulins & Their Genes, H.W. Schroeder
14. Structure and Function of Monocytes/Macrophages and Other Antigen Presenting Cells, Mary K. Crow
15. Structure & Function of Lymphocytes, Robert H. Carter
16. Structure & Function of Neutrophils, Bruce N. Cronstein
17. Mast Cells and Eosinophils in the Rheumatic Diseases, Allen P. Kaplan
18. Platelets in the Rheumatic Diseases, M.N. Saleh
19. Cytokines and their Receptors, Cem Gabay
20. Cell Adhesion Molecules in the Rheumatic Diseases, D.C. Bullard
21. Molecular Biology of the Complement System, J.E. Volanakis
22. Acute-Phase Proteins in the Rheumatic Diseases, J.E. Volanakis
23. Eicosanoids and Related Compounds, C.N. Serhan
24. Nitric Oxide and Related Compounds, G. S. Gilkeson
25. Characteristics of Immune Complexes and the Principles of Immune Complex Diseases, R.P. Kimberly
26. Apoptosis and Autoimmune Disease, J. D. Mountz
27. Structure, Function, and Genetics of the HLA Complex in Rheumatic Disease, Jane Buckner, Gerry Nepom
28. Genetic Basis of the Rheumatic Diseases, John B. Harley
29. Arthritis and Autoimmunity in Animals, Phil Cohen
30. Infectious Agents in Chronic Rheumatic Diseases, R. D. Inman

Section III: Therapeutic Approaches in the Rheumatic Diseases
31. Nonsteroidal Anti-Inflammatory Drugs, John Sundy
32. Methotrexate & Lefunomide: Use in the Treatment of Rheumatoid Arthritis and Other Rheumatic Diseases, Graciela Alarcon
33. Combination Drug Therapy, H. J. Williams
34. Glucocorticoids, Dimitrios Boumpas
35. Arthrocentesis: Technique and Therapeutic Options, Gerald Moore
36. Bone Marrow and Stem Cell Transplantation, Lynell W. Klassen
37. Gene Therapy: Potential Applications in Arthritis, Ulf Muller-Ladner
38. Rehabilitation in the Rheumatic Diseases, Rowland W. Chang
39. Cytokine Inhibitors: Tumor Necrosis Factor and Interleukin-1, Joan Bathon
40. Potential Biological Therapies, Joseph Shanahan and Larry Moreland
41. Immunomodulatory Agents (cyclosporine, FK506, mycophenolate, azathioprine, cyclophosphamide), Grant Cannon
42. Traditional DMARDs (Gold, Sulfasalazine, D-penicillamine, Antimalarials), W. Winn Chatham
43. Alternative Therapies, Daniel Clegg