This text uses a more brief and qualitative approach to present biochemistry with chemical rigor, focusing on the structures of biomolecules, chemical mechanisms, and evolutionary relationships. It is written to impart a sense of intellectual history of biochemistry, an understanding of the tools and approaches used to solve biochemical puzzles, and a hint of the excitement that accompanies new discoveries. This edition has been thoroughly updated to reflect the most recent advances in biochemistry, particularly in the areas of genomics and structural biology. A new chapter focuses on cytoskeletal and motor proteins, currently one of the most active areas of research in biochemistry.

Table of Contents:

PART ONE: INTRODUCTION
1. Introduction to the Chemistry of Life
2. Water

PART TWO: BIOMOLECULES
3. Nucleotides, Nucleic Acids, and Genetic Information
4. Amino Acids
5. Proteins: Primary Structure
6. Proteins: Three-Dimensional Structure
7. Protein Function Part 1: Myoglobin and Hemoglobin
8. Protein Function Part 2: Cytoskeletal and Motor Proteins
9. Carbohydrates
10. Lipids and Biological Membranes
11. Membrane Transport

PART THREE: ENZYMES
12. Enzymatic Catalysis
13. Enzyme Kinetics, Inhibition, and Regulation

PART FOUR: METABOLISM
14. Introduction to Metabolism
15. Glucose Metabolism
16. Glycogen Metabolism and Gluconeogenesis
17. Citric Acid Cycle
18. Electron Transport and Oxidative Phosphorylation
19. Photosynthesis
20. Lipid Metabolism
21. Amino Acid Metabolism
22. Mammalian Fuel Metabolism: Integration and Regulation
23. Nucleotide Metabolism

PART FIVE: REPLICATION AND GENE EXPRESSION
24. Nucleic Acid Structure
25. DNA Replication, Repair, and Recombination
26. Transcription and RNA Processing
27. Protein Synthesis