Contents

PART I - CARDINAL MANIFESTATIONS OF CANCER

1 Cardinal Manifestations of Cancer

PART II - SCIENTIFIC FOUNDATIONS OF CANCER

Section 1 - Cancer Biology
2 Molecular Biology, Genomics, and Proteomics
3 Cell Proliferation and Differentiation
4 Apoptosis
5 Signal Transduction
6 Oncogenes
7 Tumor Suppressor Genes
8 Recurring Chromosome Rearrangements in Cancer
9 Biochemistry of Cancer
10 Invasion and Metastases
11 Tumor Angiogenesis

Section 2 - Cancer Immunology
12 Tumor Antigens
13 Tumor Markers and Immunodiagnosis
14 Effectors of Immunity and Rationale for Immunotherapy
15 Tumor-Associated Immunodeficiency and Implications for Tumor Development and Prognosis

Section 3 - Cancer Etiology
16 Genetic Predisposition to Cancer
17 Chemical Carcinogenesis
18 Hormones and the Etiology of Cancer
19 Ionizing Radiation
20 Ultraviolet Radiation Carcinogenesis
21 Physical Carcinogens and Trauma and Inflammation
22 Tumor Viruses
23 Herpesviruses
24 Papillomaviruses and Cervical Neoplasia
25 Hepatitis Viruses
26 Parasites

Section 4 - Cancer Epidemiology, Prevention, and Screening
27 Cancer Epidemiology
28 Prevention of Tobacco-Related Products
29 Nutrition in the Etiology and Prevention of Cancer
30 Chemoprevention of Cancer
31 Cancer Screening and Early Detection

Section 5 - Clinical Trials and Outcomes Assessment
32 Biostatistics
33 Clinical Trial Design
34 Outcomes Assessment

PART III - PRINCIPLES OF CANCER DIAGNOSIS

Section 6 - Cancer Pathology
35 Principles of Cancer Pathology

Section 7 - Imaging
36 Principles of Imaging
36a Cancer of Unknown Primary Site
36b Head and Neck and Central Nervous System
36c The Thorax
36d Abdomen and Pelvis
36e Cross-Sectional Imaging of Musculoskeletal Neoplasms
36f The Breast
36g Ultrasound in Cancer Medicine
36h Radionuclide Imaging in Cancer Medicine
36i Perspectives in Imaging
37 Interventional Radiology for the Cancer Patient

PART IV - PRINCIPLES OF THERAPEUTIC MODALITIES

Section 8 - Surgical Oncology
38 Principles of Surgical Oncology

Section 9 - Radiation Oncology
39 Principles of Radiation Oncology
40 Photodynamic Therapy of Cancer
41 Hyperthermia

Section 10 - Medical Oncology
42 Principles of Medical Oncology

Section 11 - Chemotherapy
43 Cytokinetics
44 Dose, Schedule, and Combination Chemotherapy
45 Drug Discovery and Preclinical Evaluation
46 Pharmacology
47 Regional Chemotherapy
48 Drug Resistance and its Clinical Circumvention

Section 12 - Chemotherapeutic Agents
49 Folate Antagonists
50 Pyrimidine and Purine Antimetabolites
51 Alkylating Agents and Platinum Antitumor Compounds
52 Anthracyclines and DNA Intercalators/Epipodophyllotoxins/DNA Topoisomerases
53 Microtubule-Targeting Anticancer Drugs derived from Plants and Microbes: Vinca Alkaloids, Taxanes, and Epothilones
54 Targeted Therapy

Section 13 - Biotherapeutics
55 Aspariginase
56 Interferons
57 Cytokines
58 Hematopoietic Growth Factors
59 Antibodies
60 Vaccines and Immunostimulants

Section 14 - Endocrine Therapy
61 Hypothalamic and Other Peptide Hormones
62 Corticosteroids
63 Estrogens and Antiestrogens
64 Aromatase Inhibitors
65 Progestins
66 Androgens

Section 15 - Gene Therapy
67 Gene Therapy

Section 16 - Bone Marrow Transplantation
68 Autologous Bone Marrow and Stem Cell Transplantation
69 Transplantation of Allogeneic Hematopoietic Cells

PART V - PRINCIPLES OF MULTIDISCIPLINARY MANAGEMENT

Section 17 - Psycho-Oncology
70 Psycho-Oncology

Section 18 - Oncology Nursing
71 Oncology Nursing

Section 19 - Cancer Rehabilitation Medicine
72 Cancer Rehabilitation Medicine

Section 20 - Multidisciplinary Management
73 Multidisciplinary Management
74 Pregnancy and Cancer
75 Cancer and Aging
76 Complementary and Alternative Medicine

Section 21 - Pain and Palliation
77 Palliative Care
78 Cancer Pain

Section 22 - Societal Oncology
79 Ethics in Oncology
80 Legal Aspects of Cancer
81 The Government and Cancer Medicine
82 Clinical Oncology in a Changing Health Care Environment

PART VI - CANCER MANAGEMENT

Section 23 - Central Nervous System
83 Central Nervous System
84 Central Nervous System Metastases

Section 24 - The Eye
85 The Eye

Section 25 - Endocrine Glands
86 The Pituitary
87 The Thyroid
88 Adrenal Cortex
89 Neuroendocrine System and Gastroenteropancreatic Endocrine System

Section 26 - Head and Neck
90 Head and Neck
91 Odontogenic Tumors

Section 27 - The Thorax
92 The Lung
93 Malignant Mesothelioma
94 Thymomas and Thymic Tumors
95 Heart and Great Vessels
96 Primary Germ Cell Tumors
97 Metastatic Tumors

Section 28 - Gastrointestinal Tract
98 The Esophagus
99 The Stomach
100 Primary Neoplasms of the Liver
101 Liver Metastases
102 Gallbladder and Biliary Tree
103 Ampulla of Vater and Exocrine Pancreas
104 Small Intestine
105 Vermiform Appendix and Peritoneum
106 Colon and Rectum
107 The Anus

Section 29 - Genitourinary Tract
108 Renal Cell Carcinoma
109 Renal Pelvis and Ureter
110 The Bladder
111 The Prostate
112 The Penis
113 The Testis

Section 30 - Female Reproductive Organs
114 Vulva and Vagina
115 The Cervix
116 Endometrial Cancer
117 Neoplasms of the Fallopian Tube
118 The Ovaries
119 Gestational Trophoblastic Disease
120 Gynecologic Sarcomas

Section 31 - The Breast
121 The Breast

Section 32 - The Skin
122 Malignant Melanoma
123 Other Skin Cancers

Section 33 - Bone and Soft Tissue
124 Bone Tumors
125 Soft Tissue Sarcomas

Section 34 - Hematopoietic System
126 Myelodysplastic Syndrome
127 Acute Myeloid Leukemia in Adults
128 Chronic Myeloid Leukemia
129 Acute Lymphocytic Leukemia in Adults
130 Chronic Lymphocytic Leukemia
131 Hairy-Cell Leukemia
132 Mast Cell Leukemia and Other Mast Cell Neoplasms
133 Hodgkin's Disease
134 Non-Hodgkin's Lymphomas
135 Mycosis Fungoides and the Sézary Syndrome
136 Plasma Cell Tumors
137 Polycythemia Vera and Essential Thrombocythemia

Section 35 - Neoplasms in AIDS
138 Neoplasms in Acquired Immunodeficiency Syndrome

Section 36 - Unknown Primary Site
139 Neoplasms of Unknown Primary Site

Section 37 - Pediatric Oncology
140a Principles of Pediatric Oncology
140b Incidence and Epidemiology
140c Late Effects of Cancer and its Treatment
141a Acute Lymphoblastic Leukemia
141b Acute Myeloid Leukemia
141c Primary Central Nervous System Tumors
141d Hodgkin's Disease
141e Non-Hodgkin's Lymphoma
142a Less Frequently Encountered Tumors
142b Renal Tumors
142c Neuroblastoma
142d Soft Tissue Sarcomas
143a Unique Pathological Features of Childhood Cancer
143b Special Considerations for Adolescents and Young Adults

Section 38 - Complications of Cancer and Their Treatment
144 Anorexia and Cachexia
145 Antiemetic Therapy
146 Neurologic Complications
147 Dermatologic Complications
148 Skeletal Complications
149 Hematologic Complications and Blood Bank Support
150 Coagulopathic Complications of Cancer
151 Urologic Complications
152 Cardiac Complications
153 Respiratory Complications
154 Liver Function and Hepatotoxicity
155 Gastrointestinal Complications
156 Oral Complications
157 Gonadal Complications
158 Endocrine Complications and Paraneoplastic Syndromes
159 Secondary Cancers: Incidence, Risk Factors, and Management

Section 39 - Infection in the Cancer Patient
160 Infection in the Cancer Patient

Section 40 - Oncologic Emergencies
161 Oncologic Emergencies

Section 41 - Oncology and Informatics
162 Oncology and Informatics