The new edition of genomes has been completely rewritten to take in to account both the demands of lecturers and students. Genomes, second edition has been reworked to make it more appropriate for introductory undergraduate study. The book has also been thoroughly updated to reflect our increased knowledge of this fast moving field.

KEY CHANGES FROM THE FIRST EDITION:
* Appropriate for introductory level courses
* Re-arranged chapter organisation to reflect student needs
* Expansion of most chapters to provide greater background knowledge
* Increased emphasis on experimental data
* Review questions at the end of every chapter

Contents
PART 1 - GENOMES, TRANSCRIPTOMES AND PROTEOMES
CH 1 THE HUMAN GENOME
DNA
The human genome
Why is the human genome project important?
CH 2 GENOME ANATOMIES
An overview of genome anatomies
The anatomy of the eukaryotic genome
The anatomy of the prokaryotic genome
The repetitive DNA content of genomes
CH 3 TRANSCRIPTOMES AND PROTEOMES
Genome expression in outline
The RNA content of the cell
Protein structure of the cell
PART 2 STUDYING GENOMES
CH 4 STUDYING DNA
Enzymes for DNA manipulation
DNA cloning
The polymerase chain reaction (PCR)
CH 5 MAPPING GENOMES
Genetic and physical maps
Genetic mapping
Physical mapping
CH 6 SEQUENCING GENOMES
The methodology for DNA sequencing
Assembly of a contiguous DNA sequence
The human genome projects
CH 7 UNDERSTANDING A GENOME SEQUENCE
Locating the genes in a genome sequence
Determining the functions of individual care
Global studies of genome activity
Comparative genomics
PART 3 - HOW GENOMES FUNCTION
CH 8 ACCESSING THE GENOME
Inside the nucleus
Chromatin modifications and genome expression
CH 9 ASSEMBLY OF THE TRANSCRIPTION INITIATION COMPLEX
The importance of DNA-binding proteins
DNA-protein interactions during transcription initiation
Regulation of transcription initiation
CH 10 SYNTHESIS AND PROCESSING OF RNA
Synthesis and processing of mRNA
Synthesis and processing of non-coding RNAs
Processing of Pre-RNA by chemical modification
Degradation of mRNAs
Transport of RNA within the eukaryotic cell
CH 11 SYNTHESIS AND PROCESSING OF THE PROTEOME
The role of tRNA in protein synthesis
The role of the ribosome in protein synthesis
Post-translational processing of proteins
Protein degradation
CH 12 REGULATION OF GENOME ACTIVITY
Transient changes in genome activity
Permanent and semipermanent changes in genome activity
Regulation of genome activity during development
PART 4 - HOW GENOMES REPLICATE AND EVOLVE
CH 13 GENOME REPLICATION
The tropological problem
The replication process
Regulation of eukaryotic genome replication
CH 14 MUTATION, REPAIR AND RECOMBINATION
Mutations
DNA repair
Recombination
CH 15 HOW GENOMES EVOLVE
Genomes: the first 10 billion years
Acquisition of new genes
Non-coding DNA and genome evolution
The human genome: the last 5 million years
CH 16 MOLECULAR PHYLOGENETICS
The origins of molecular phylogenetics
The reconstruction of DNA-based phylogenetic trees
The applications of molecular phylogenetics