This companion to Brenner and Rector's The Kidney offers a concise, practical approach to acid-base and electrolyte disorders, emphasizing pathophysiology and its link to a logical diagnostic approach in treating these disorders. Unlike other traditional textbooks on the subject, Acid/Base and Electrolyte Disorders focuses less on physiological and pathophysiological concepts and more on providing specific recommendations for therapy and patient care - resulting in an excellent clinical resource that is also an ideal core curriculum or exam review. Many of the topics in this book are not covered in any other resource, including acid-base and electrolyte disorders in the critical care setting. In addition, recent advances in fast-developing areas such as genetic and molecular biology are discussed in detail.

Features

Emphasizes acid-base and electrolyte abnormalities in the critical care setting - a topic not fully covered in any other resource.
Includes the most up-to-date information on hot topics such as molecular biology and genetics of tubular transport abnormalities, hypertension, and calcium, sodium, and potassium homeostasis.
Authors and contributors are experts in their field, providing the most authoritative information available.
Figures and tables throughout the book help clarify important concepts.
A detailed reference list for each chapter directs the reader to sources for further information, and readers are referred back to Brenner and Rector's The Kidney for complete discussions the complex physiology of certain disorders.

Contents

I. Acid Base Disorders

Regulation of whole body acid-base balance
Urinary acidification
Diagnosis of simple and mixed disorders
Metabolic acidosis
Ketoacidosis
Lactic acidosis
Metabolic alkalosis
Respiratory acidosis
Respiratory alkalosis
Acid-base disorders in the critical care setting
Renal tubular acidosis
The acidosis of CRF


II. Water

Cell biology of vasopressin and the aquaporins
Hyponatremia
Hypernatremia and the polyuric disorders


III. Electrolytes: Sodium

Sodium transport in the kidney
The renin-angiotensin-aldosterone system
The edematous disorders
Salt washing
Genetic disorders of renal electrolyte transport
Electrolyte abnormalities in the ICU


IV. Electrolytes: Potassium

Regulation of renal potassium transport
Hypokalemia
Hyperkalemia
Aldosterone deficiency and resistance


V. Electrolytes: Divalent Ions

1. Renal regulation of calcium, magnesium, and phosphorus
2. Abnormal calcium and magnesium metabolism
3. Hypophosphatemia and hyperphosphatemia
4. Idiopathic hypercalciuria and renal stone disease