Chronic obstructive pulmonary disease is, of 2024, one of the three main causes of death in the world, affecting around 12% of the world's population. Its incidence is estimated to increase in the coming decades due to continuous exposure to risk factors and to an aging population.

Pulmonary emphysema is one of its most serious phenotypes, with chronic and inexorable progression and, in the most severe stages, it is highly disabling and lethal.

This book reviews knowledge about the pathophysiology of severe pulmonary emphysema and the current innovative interventional and minimally invasive therapeutic concepts for the management of these advanced stages of emphysema, based on the best scientific evidence.

This guide provides to multidisciplinary pulmonary boards of experts in advanced lung diseases, current criteria for the choice of precision therapeutic options and beyond to maintaining optimized medical treatment to controlling lung hyperinflation, and alleviating patients'symptoms.

This book is a valuable resource for clinicians dealing with critically ill patients with COPD.


Foreword I
Foreword II
Preface
Acknowledgments
About the Editors
Contributors
1 Pathophysiology of Emphysema
2 Pulmonary Functional Evaluation for the Safe Performance of Lung Volume Reduction
3 The Concept of Lung Volume Reduction and the Best Evidence
4 Surgical Concepts and the Techniques of Lung Volume Reduction Surgery
5 Image Analysis to Identify Target Areas for Lung Volume Reduction
6 Nuclear Medicine Techniques in Pre- and Post-Procedural Evaluation of Lung Volume Reduction Interventions and of Single Pulmonary Nodule
7 Precision Treatment for Severe Lung Emphysema and the Impact of a Multidisciplinary Lung Team
8 Current Optimized Medical Treatment and the Impact on Dynamic Hyperinflation
9 Lung Volume Reduction Surgery: Technique, Tips, and Challenges
10 Extending Candidacy for Lung Volume Reduction Surgery
11 The Interface between Lung Emphysema and Lung Cancer
12 Bronchoscopic Lung Volume Reduction Innovations
13 Peri-Interventional Clinical Management of Endoscopic Emphysema Treatment
14 Bronchoscopic Lung Volume Reduction with One-Way Valves: Prevention and Management of Complications
15 Pulmonary Rehabilitation for COPD Patients
16 Results and Long-Term Follow-Up of Interventional Treatments for Lung Emphysema: Quality-of-Life Considerations
17 The Future of Treating Hyperinflation in Emphysema
Index