Covering the broad range of benign and malignant disorders that affect the hematopoietic system, Hematopathology, 3rd Edition, remains your 1 source of authoritative information in this fast-changing field. Edited by Dr. Elaine Jaffe and a team of globally renowned, expert co-editors, it offers a wealth of up-to-date information in an easily accessible format, equipping you to deliver more accurate and actionable pathology reports. Comprehensive in scope, this highly illustrated, practical text is a must-have resource for residents and practicing pathologists alike.

Helps you navigate the latest changes in the classification of hematolymphoid neoplasms, providing guidance for use of both the International Consensus Classification (ICC) and 5th edition of the WHO classification.
Incorporates the latest molecular/cytogenetic information, regarding newly recognized entities and the latest diagnostic criteria.
Provides you with today's most effective guidance in evaluating specimens from the lymph nodes, bone marrow, peripheral blood, and more, with authoritative information on the pathogenesis, clinical and pathologic diagnosis, and treatment for each.
Details the latest insights on the molecular biology of benign and malignant hematologic disorders.
Features more than 1,100 high-quality color images that mirror the findings you encounter in practice.
Uses an easy-to-navigate, templated format with standard headings in each chapter.
Includes information on disease progression and prognosis, helping you better understand the clinical implications of diagnosis.
Shares the knowledge and expertise of new editors, Drs. Lisa Rimsza, Attilio Orazi, and Steven Swerdlow, providing expertise in molecular diagnostics, bone marrow and lymph node biopsies.
An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date.
Author Information
By Elaine Sarkin Jaffe, MD, Chief, Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Clinical Professor of Pathology, George Washington University School of Medicine; Series Editor, World Health Organization Classification of Tumours 4th Edition, International Agency for Research on Cancer, Bethesda, Maryland; Daniel A. Arber, MD, Professor and Chair of Pathology, University of Chicago School of Medicine, USA; Elias Campo, MD, Chief, Hematopathology Unit, Professor of Anatomic Pathology, Clinical Director, Center for Biomedical Diagnosis, Hospital Clinic, University of Barcelona, Barcelona, Spain; Leticia Quintanilla-Fend, MD, Associate Professor, Institute of Pathology, Eberhard-Karls-University; Senior Staff, Institute of Pathology, University Hospital and Comprehensive Cancer Center, Tübingen, Germany; Attilio Orazi, MD, Chair, Department of Pathology, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas; Lisa M. Rimsza, MD, Department of Pathology Mayo Clinic and Steven H. Swerdlow, MD, Professor of Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA



PART I Technical Aspects
1 Processing of the Lymph Node Biopsy Specimen
2 Fine-Needle Aspiration of Lymph Nodes
3 Immunohistochemistry for the Hematopathology Laboratory
4 Flow Cytometry
5 Molecular Pathology of Hematologic Neoplasms
6 Important Chromosomal Aberrations in Hematologic Neoplasms and Key Techniques to Diagnose Them
PART II Normal and Reactive Conditions of Hematopoietic Tissues
7 Normal Lymphoid Organs and Tissues
8 Reactive Lymphadenopathies
9 The Normal Bone Marrow
10 Evaluation of Anemia, Leukopenia, and Thrombocytopenia
11 Bone Marrow Findings in Inflammatory, Infectious, and Metabolic Disorders
PART III Lymphoid Neoplasms
12 Principles of Classification of Lymphoid Neoplasms
SECTION 1 MATURE B-CELL NEOPLASMS
13 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Monoclonal B-Cell Lymphocytosis, and B-Cell Prolymphocytic Leukemia
14 Lymphoplasmacytic Lymphoma and Waldenström Macroglobulinemia
15 Hairy Cell Leukemia
16 Splenic Marginal Zone Lymphoma and Other Small B-Cell Neoplasms in the Spleen
17 Follicular Lymphoma
18 Extranodal Marginal Zone Lymphoma: MALT Lymphoma
19 Primary Cutaneous B-Cell Lymphomas
20 Nodal Marginal Zone Lymphoma
21 Mantle Cell Lymphoma
22 Aggressive B-Cell Lymphomas Including Diffuse Large B-Cell Lymphoma, Not Otherwise Specified and Other Nodal and Extranodal Large B-Cell Lymphomas
23 Burkitt Lymphoma, High-Grade B-Cell Lymphoma Not Otherwise Specified, High-Grade B-Cell Lymphoma With MYC and BCL2/BCL6 Rearrangements, Large B-Cell Lymphoma With 11q Aberration, and Provisional Entity High-Grade B-Cell Lymphoma With MYC and BCL6 Rearrangements
24 Plasmablastic Neoplasms Other Than Plasma Cell Myeloma
25 Plasma Cell Neoplasms
26 Nodular Lymphocyte-Predominant B-Cell Lymphoma
27 Classic Hodgkin Lymphoma
28 Virally Associated B-Cell Lymphoproliferative Disease
SECTION 2 MATURE T-CELL AND NK-CELL NEOPLASMS
29 Epstein-Barr Virus Associated T-Cell and Natural Killer Cell Lymphoproliferative Disorders
30 T-Cell and NK-Cell Large Granular Lymphocyte Proliferations
31 T-Cell Prolymphocytic Leukemia
32 Adult T-Cell Leukemia/Lymphoma
33 Hepatosplenic T-Cell Lymphoma
34 Peripheral T-Cell Lymphoma, Not Otherwise Specified
35 Follicular Helper T-Cell Lymphoma
36 Anaplastic Large Cell Lymphoma, ALK Positive and ALK Negative
37 Enteropathy-Associated T-Cell Lymphoma and Other Primary Intestinal T-Cell Lymphomas
38 Mycosis Fungoides and Sézary Syndrome
39 Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders
40 Primary Cutaneous T-Cell Lymphomas: Rare Subtypes
SECTION 3 PRECURSOR B- AND T-CELL NEOPLASMS
41 Precursor B-Cell and T-Cell Neoplasms
42 Acute Leukemias of Ambiguous Lineage
PART IV Myeloid, Histiocytic, and Related Proliferations
43 Principles of Classification of Myeloid Neoplasms
44 The Myelodysplastic Syndromes
45 Myeloid and Hematologic Neoplasms With Germline Predisposition
46 Acute Myeloid Leukemia
47 Myeloproliferative Neoplasms
48 Myelodysplastic/Myeloproliferative Neoplasms and Premalignant Conditions
49 Mastocytosis
50 Eosinophilia, Chronic Eosinophilic Leukemia, Not Otherwise Specified, and Myeloid/Lymphoid Neoplasms With Eosinophilia and Tyrosine Kinase Gene Fusions
51 Blastic Plasmacytoid Dendritic Cell Neoplasm
52 Histiocytic and Dendritic Cell Proliferations Systemic and Neoplastic
PART V Immunodeficiency Disorders
53 The Pathology of Primary Immunodeficiencies
54 Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders
PART VI Site-Specific Issues in the Diagnosis of Lymphoma and Leukemia
55 Bone Marrow Evaluation for Lymphoma
56 Evaluation of the Bone Marrow After Therapy
57 Non-hematopoietic Neoplasms and Other Lesions of the Bone Marrow and Lymph Nodes
58 Spleen: Normal Architecture and Neoplastic and Non-neoplastic Lesions
59 Diagnosis of Lymphoma in Extranodal Sites Other Than Skin

APPENDIX A: THE INTERNATIONAL CONSENSUS CLASSIFICATION OF MYELOID, LYMPHOID, AND HISTIOCYTIC NEOPLASMS

INDEX