Hayes' Principles and Methods of Toxicology has long been established as a reliable and informative reference for the concepts, methodologies, and assessments integral to toxicology. The new edition contains updated and new chapters with the addition of new authors while maintaining the same high standards that have made this book a benchmark resource in the field.

Key Features:

The comprehensive yet concise coverage of various aspects of fundamental and applied toxicology makes this book a valuable resource for educators, students, and professionals.
Questions provided at the end of each chapter allow readers to test their knowledge and understanding of the material covered.
All chapters have been updated and over 60 new authors have been added to reflect the dynamic nature of toxicological sciences
New topics in this edition include Safety Assessment of Cosmetics and Personal Care Products, The Importance of the Dose/Rate Response, Novel Approaches and Alternative Models, Epigenetic Toxicology, and an Expanded Glossary.
The volume is divided into 4 major sections, addressing fundamental principles of toxicology (Section I. "Principles of Toxicology"), major classes of established chemical hazards (Section II. "Agents"), current methods used for the assessment of various endpoints indicative of chemical toxicity (Section III. "Methods"), as well as toxicology of specific target systems and organs (Section IV. "Organ- and System-Specific Toxicology").

This volume will be a valuable tool for the audience that wishes to broaden their understanding of hazards and mechanisms of toxicity and to stay on top of the emerging methods and concepts of the rapidly advancing field of toxicology and risk assessment.


SECTION I Principles of Toxicology

Chapter 1 History, Understanding and a Possible Future of Toxicology. Harming and Helping through Time.

Richard W. Lane with revisions and a new section by Anthony D. Dayan

Chapter 2 Use of Toxicology in the Regulatory Process

Robyn L. Prueitt, Barbara D. Beck, and Edward J. Calabrese

Chapter 3 The Dose Response: A Fundamental Concept in Toxicology

Edward J. Calabrese

Chapter 4 Metabolism: A Determinant of Toxicity

Tao Wang and Richard Zang

Chapter 5 Toxicokinetics

Leanne L. Bedard

Chapter 6 Physiologically Based Pharmacokinetic and Toxicokinetic Models

Harvey J. Clewell III, Rebecca A. Clewell, and Melvin E. Andersen

Chapter 7 Toxicopanomics: Applications of Genomics, Transcriptomics,
Proteomics, Metabolomics and Lipidomics in Predictive Mechanistic Toxicology

Mohamed-Amin Choukrallah, Marja Talikka, Stephanie Boue, Philippe Alexandre Guy, Aditya Reddy Kolli, Sandro Steiner, David Bovard, Diego Marescotti, Oksana Lavrynenko, Catherine Nury, James N. Battey, Bjorn Titz, Ulrike Kogel, Alain Sewer, Nicolas Sierro, Florian Martin, Nikolai V. Ivanov, Manuel C. Peitsch, and Julia Hoeng

Chapter 8 Toxicologic Assessment of Pharmaceutical, Medical Device and Biotechnology Products

Michael A. Dorato, Caitlin J. Murphy, J. Scott Daniels, Erin M. Quist, and C. Steven Godin

Chapter 9 Statistics and Experimental Design for Toxicologists

Shayne C. Gad

Chapter 10 The Practice of Exposure Assessment

Dennis J. Paustenbach, Amy K. Madl, and Andrey Massarsky

Chapter 11 Epidemiology for Toxicologists

Geary W. Olsen, Robert R. Roy, Sarah E. Kleinschmidt, and Ralph R. Cook

Chapter 12 Pathology Principles and Practices for Toxicity Studies

Brad Bolon, Tara Arndt, Adam Aulbach, and Kenneth A. Schafer

Chapter 13 Chemical Toxicology Information Resources

Stephanie Holmgren, Jacqueline Patterson, Kristina Thayer, Philip Wexler, and Antony J. Williams

SECTION II Agents

Chapter 14 Food Safety and Foodborne Toxicants

Fleur De Mooij, Yu Janet Zang, Amy L. Roe, and Angelika Tritscher

Chapter 15 Plant and Animal Toxins

Kevin D. Welch, Glenn F. King, Julian White, Leanne A. Pearson, Brett A. Neilan, and Daniel Cook

Chapter 16 Safety Assessment of Cosmetics and Personal Care Products

Christina Hickey, Siti Amelia Juraimi, Lauren Hutchison, Anne Marie Api, and Benjamin P.C. Smith

Chapter 17 Solvents and Industrial Hygiene

John E. Snawder

Chapter 18 Crop Protection Chemicals: Mechanism of Action and Hazard Profiles

James Bus

Chapter 19 Metals

Paul B. Tchounwou, Joseph R. Landolph, Jr., and Janis E. Hulla

Chapter 20 Radiation Toxicity

Roger O. McClellan

SECTION III Methods

Chapter 21 The Humane Care and Use of Laboratory Animals in Toxicology Research

Michael J. Caruso, Tyler C. Plachta, Christopher N. Papagiannis, Zac Lloyd, Dale M. Cooper, and David G. Serota

Chapter 22 Novel Approaches and Alternative Models. Validation and Regulatory Acceptance of Toxicological Testing Methods and Strategies

Nicole Kleinstreuer and David Allen

Chapter 23 Modern Instrumental Methods for Studying Mechanisms of Toxicology

W.M. Coleman, III, Serban C. Moldoveanu, Mehdi Ashraf-Khorassini, and Francis L. Martin

Chapter 24 Acute Toxicity and Eye Irritancy

Saura C. Sahu and A. Wallace Hayes

Chapter 25 Short-Term, Subchronic, and Chronic Toxicology Studies

Daniel T. Wilson, Jerry F. Hardisty, Torrie A. Crabbs, and Shannon M. Wallace

Chapter 26 Genetic and Epigenetic Toxicology

Leslie Recio and Tetyana Kobets

Chapter 27 Carcinogenicity Bioassays and Related Assays; Human Relevance

Gary M. Williams, Tetyana Kobets, Michael J. Iatropoulos, Thomas Nolte, and Esther Vock

Chapter 28 Assessment of Behavioral Toxicity

Deborah A. Cory-Slechta and Marissa Sobolewski

SECTION IV Organ- and System-Specific Toxicology

Chapter 29 Dermatotoxicology

Benjamin B. Hayes and Howard J. Maibach

Chapter 30 Inhalation Toxicology

John J. Godleski, Sandra A. McDonald, and Lester Kobzik

Chapter 31 Gastrointestinal Toxicology

Peter Pressman, Roger Clemens, and Robert W. Kapp, Jr.

Chapter 32 Hepatotoxicology

Maksat Babayev, Luma Melo, and James Klaunig

Chapter 33 Principles and Methods for Renal Toxicology

Jennifer G. Schnellmann and Rick G. Schnellmann

Chapter 34 Cardiovascular Toxicology Methods

Barry Bleske and Matthew J. Campen

Chapter 35 Neurotoxicology

Anke M. Tukker, Aaron B. Bowman, Lucio G. Costa, and Michael Aschner

Chapter 36 Toxicology of the Endocrine System

Carr J. Smith, Thomas A. Perfetti, and Judy A. King

Chapter 37 Assessment of Male Reproductive Toxicity

Natasha R. Catlin, Jon C. Cook, and Gregg D. Cappon

Chapter 38 Female Reproductive and Developmental Toxicology

Stephen B. Harris, Kary E. Thompson, Pragati S. Coder, Eve Mylchreest, Amy Lavin Williams, and John M. DeSesso

Chapter 39 Immunotoxicology. The Immune System Response to Toxic Insult

Florence G. Burleson, Stefanie C.M. Burleson, Gary R. Burleson, and Victor J. Johnson