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Handbook of Pediatric Epilepsy Case Studies

Research in the field of epilepsy will continue at a rapid pace, with the ultimate hope of curing many intractable epilepsy syndromes. Fully updated, this new edition is organized chronologically, from neonate through adolescence, and the handbook is the culmination of a group effort involving leading physicians and researchers whose contributions constitute a concise and practical reference for health professionals in training. Here the contributors review the recent flood of new information on the pathophysiology, genetics, and treatment of the various epilepsy syndromes, and the volume is distilled into an easy-to-use guide.

Fully updated text reviewing the latest research on the pathophysiology, genetics, and treatment of the various epilepsy syndromes.
Thorough descriptions of the different syndromes commonly encountered in clinical practice across the pediatric range.
Extensive resource section provided.
Contributors describe why they chose each particular case, what they learned, and how it changed their practice.
The book includes the most recent classification and nomenclature published by the International League Against Epilepsy.
Maria Augusta Montenegro is a pediatric neurologist and epileptologist currently working at Rady Children's Hospital / University of California San Diego School of Medicine. Her clinical expertise is in pediatric epilepsy, with an emphasis on epileptic encephalopathy and EEG. Dr. Montenegro completed medical school, residency, and Ph.D. at the University of Campinas (Brazil) and a post-doctorate research fellowship at Columbia University (NY). Prior to her current position, Dr. Montenegro held an academic faculty appointment at the University of Campinas (Brazil) where she was the head of Pediatric Neurology.

Dr. Jong M. Rho is a Professor of Neurosciences, Pediatrics and Pharmacology at the University of California San Diego, and Division Chief of Pediatric Neurology at the Rady Children's Hospital San Diego. He received a bachelor's degree in molecular biophysics and biochemistry at Yale University, and a M.D. from the University of Cincinnati. Dr. Rho has held prior faculty appointments at the University of Washington (Seattle), the University of California at Irvine, the Barrow Neurological Institute (Phoenix), and most recently, the University of Calgary. Dr. Rho's main research interests are the mechanisms underlying the anti-seizure and neuroprotective effects of metabolism-based treatments such as the ketogenic diet. His research activities have been sponsored by research grants from the U.S. National Institutes of Health, Canadian Institutes of Health Research, and other public and private sector sources.

Section I: The Basics

Chapter 1

A Pediatric Epilepsy Primer

James W. Owens, MD, PhD

Chapter 2

Epilepsy Genetics Primer

Kimberly Wiltrout, MD and Annapurna Poduri, MD, MPH

Chapter 3

Developmental Pharmacokinetics: Principles and Practice

Melissa Barker-Haliski, PhD

Chapter 4

Dietary Therapies for Epilepsy

Eric H. Kossoff, MD

Chapter 5

Vagus Nerve Stimulation Therapy

James W. Wheless, MD, Nitish Chourasia, M.D and Andrew J. Gienapp, B.A.

Chapter 6

Neuromodulation Devices: Responsive Neurostimulation and Deep Brain Stimulation

Shifteh S. Sattar, MD

Chapter 7

Epilepsy Surgery in Children

Ann Hyslop, MD

Chapter 8

Status Epilepticus

Sonali Sen, MD and James J. Riviello, Jr, MD

Chapter 9

Focal Cortical Dysplasia

Harvey B. Sarnat, MD, MS, FRCPC

Chapter 10

Malformations of Cortical Development

Marilisa M. Guerreiro, MD, PhD and Maria Augusta Montenegro, MD, PhD

Section II: The Neonate

Chapter 11

Self-Limited Neonatal Epilepsy Syndromes

Maria Augusta Montenegro, MD, PhD

Chapter 12

Self-Limited (Familial) Infantile Epilepsy

Heather Pekeles, MD and Kenneth A. Myers, MD PhD

Chapter 13

Early Myoclonic Encephalopathy (Ohtahara Syndrome)

Reega Purohit, MD and Linda Laux, MD

Chapter 14

Early Myoclonic Encephalopathy

Juan Ignacio Appendino, MD and Juan Pablo Appendino, MD

Chapter 15

Hypoxic-Ischemic Encephalopathy (Neonatal Seizures)

Jeffrey J. Gold, MD, PhD

Chapter 16

Epilepsy of Infancy with Migrating Focal Seizures

Daneille DeCampo, MD and Eric Marsh MD, PhD

Section III: The Infant

Chapter 17

Febrile Seizures

Morris H. Scantlebury, MD

Chapter 18

Genetic Epilepsy with Febrile Seizures Plus (GEFS+)

Michaela Castello, MD, PhD and Aliya Frederick, MD, PhD

Chapter 19

Myoclonic Epilepsy of Infancy

Douglas R. Nordli, III, MD and Douglas R. Nordli, Jr., MD

Chapter 20

Dravet Syndrome

Douglas R. Nordli, III, MD and Douglas R. Nordli, Jr, MD

Chapter 21

Glucose Transporter-1 Deficiency Syndrome

Joerg Klepper, MD

Chapter 22

Infantile Epileptic Spasms Syndrome

Shaun A. Hussain, MD, MS

Chapter 23

Gelastic Seizures

Samiya Ahmad, MD and Yu-tze Ng, MD, FRACP

Chapter 24

Intractable Epilepsy after Herpes Simplex Encephalitis

Daniel A. Freedman, DO and Dave F. Clarke, MD

Chapter 25

Refractory Status Epilepticus

Sonali Sen, MD and James J. Riviello, Jr, MD

Chapter 26

Primary Mitochondrial Epilepsies

Russell P. Saneto, DO, PhD

Chapter 27

Tuberous Sclerosis Complex

Aimee F. Luat, MD and Harry T. Chugani, MD

Chapter 28

Sturge Weber Syndrome

Sabrina Tavella-Burka, DO and Ajay Gupta, MD

Section IV: The Child

Chapter 29

Self-Limited Epilepsy with Centrotemporal Spikes (Benign Rolandic Epilepsy)

Olivia Kim-McManus, MD

Chapter 30

Self-Limited Epilepsy with Autonomic Seizures (Panayiotopoulos Syndrome)

Korwyn Williams, MD, PhD

Chapter 31

Childhood Occipital Visual Epilepsy

Maria Augusta Montenegro, MD, PhD

Chapter 32

Photosensitive Occipital Lobe Epilepsy

Maria Augusta Montenegro, MD, PhD

Chapter 33

Childhood Absence Epilepsy

Stephane Auvin, MD, PhD, FAES

Chapter 34

Epilepsy with Myoclonic Absence

Anita M. Devlin, MBBS, MD

Chapter 35

Lennox Gastaut Syndrome

Jong M. Rho, MD

Chapter 36

Epilepsy with Myoclonic-Atonic Seizures (Doose Syndrome)

A.G. Christina Bergqvist, MD

Chapter 37

Landau Kleffner Syndrome

Frank M. C. Besag, FRCP, FRCPsych, FRCPCH

Chapter 38

Developmental/Epileptic Encephalopathy with Spike-and-Wave Activation in Sleep (D/EE-SWAS)

Kevin Chapman, MD

Chapter 39

Epilepsy with Eyelid Myoclonia (Jeavons Syndrome)

Ifrah Zawar MD and Elia Pestana Knight MD, FAES, FACNS

Chapter 40

Anti-NMDA Receptor Encephalitis

Jennifer Yang, MD and Jennifer Graves, MD, PhD, MAS

Chapter 41

Nonconvulsive Status Epilepticus

Sonali Sen, MD and James J. Riviello, Jr, MD

Chapter 42

Febrile Infection-Related Epilepsy Syndrome (FIRES)

Rima Nabbout, MD, PhD and Sara Matricardi, MD, PhD

Chapter 43

New-Onset Refractory Status Epilepticus (NORSE)

Steven Yang, DO and Jerry Shih, MD

Chapter 44

Low-Grade Developmental and Epilepsy Associated Brain Tumors

Christie Becu, MD and Angus Wilfong, MD

Chapter 45

Rasmussen's Encephalitis

Maria Augusta Montenegro, MD, PhD

Section V: The Adolescent

Chapter 46

Juvenile Myoclonic Epilepsy

Cornelia Drees, MD

Chapter 47

Epilepsy with Generalized Tonic-Clonic Seizures Alone

Kaitlin C. James and Jesus Eric Pina-Garza, MD

Chapter 48

Juvenile Absence Epilepsy

Maria Augusta Montenegro, MD, PhD

Chapter 49

New-Onset Seizure in an Adolescent Female

Mary L. Zupanc, MD

Chapter 50

Temporal Lobe Epilepsy

June Yoshii-Contreras, MD

Chapter 51

Unverricht Lundborg Disease

Mayank Verma, MD, PhD, Danielle M. Andrade, MD and Berge A. Minassian, MD, CM, FRCP(C)

Chapter 52

Reflex Seizures

Maria Augusta Montenegro

Chapter 53

Sleep-Related Hypermotor Epilepsy

Kevin Chapman, MD

Chapter 54

Psychogenic Nonepileptic Seizures

Guillermo Delgado-García, MD,MSc and Colin B. Josephson, MD, MSc, MSc, FRCP(C), CSCN (EEG)
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