Research in the field of epilepsy will continue at a rapid pace, with the ultimate hope of curing many intractable epilepsy syndromes. Fully updated, this new edition is organized chronologically, from neonate through adolescence, and the handbook is the culmination of a group effort involving leading physicians and researchers whose contributions constitute a concise and practical reference for health professionals in training. Here the contributors review the recent flood of new information on the pathophysiology, genetics, and treatment of the various epilepsy syndromes, and the volume is distilled into an easy-to-use guide.
Fully updated text reviewing the latest research on the pathophysiology, genetics, and treatment of the various epilepsy syndromes.
Thorough descriptions of the different syndromes commonly encountered in clinical practice across the pediatric range.
Extensive resource section provided.
Contributors describe why they chose each particular case, what they learned, and how it changed their practice.
The book includes the most recent classification and nomenclature published by the International League Against Epilepsy.
Maria Augusta Montenegro is a pediatric neurologist and epileptologist currently working at Rady Children's Hospital / University of California San Diego School of Medicine. Her clinical expertise is in pediatric epilepsy, with an emphasis on epileptic encephalopathy and EEG. Dr. Montenegro completed medical school, residency, and Ph.D. at the University of Campinas (Brazil) and a post-doctorate research fellowship at Columbia University (NY). Prior to her current position, Dr. Montenegro held an academic faculty appointment at the University of Campinas (Brazil) where she was the head of Pediatric Neurology.
Dr. Jong M. Rho is a Professor of Neurosciences, Pediatrics and Pharmacology at the University of California San Diego, and Division Chief of Pediatric Neurology at the Rady Children's Hospital San Diego. He received a bachelor's degree in molecular biophysics and biochemistry at Yale University, and a M.D. from the University of Cincinnati. Dr. Rho has held prior faculty appointments at the University of Washington (Seattle), the University of California at Irvine, the Barrow Neurological Institute (Phoenix), and most recently, the University of Calgary. Dr. Rho's main research interests are the mechanisms underlying the anti-seizure and neuroprotective effects of metabolism-based treatments such as the ketogenic diet. His research activities have been sponsored by research grants from the U.S. National Institutes of Health, Canadian Institutes of Health Research, and other public and private sector sources.
Section I: The Basics
Chapter 1
A Pediatric Epilepsy Primer
James W. Owens, MD, PhD
Chapter 2
Epilepsy Genetics Primer
Kimberly Wiltrout, MD and Annapurna Poduri, MD, MPH
Chapter 3
Developmental Pharmacokinetics: Principles and Practice
Melissa Barker-Haliski, PhD
Chapter 4
Dietary Therapies for Epilepsy
Eric H. Kossoff, MD
Chapter 5
Vagus Nerve Stimulation Therapy
James W. Wheless, MD, Nitish Chourasia, M.D and Andrew J. Gienapp, B.A.
Chapter 6
Neuromodulation Devices: Responsive Neurostimulation and Deep Brain Stimulation
Shifteh S. Sattar, MD
Chapter 7
Epilepsy Surgery in Children
Ann Hyslop, MD
Chapter 8
Status Epilepticus
Sonali Sen, MD and James J. Riviello, Jr, MD
Chapter 9
Focal Cortical Dysplasia
Harvey B. Sarnat, MD, MS, FRCPC
Chapter 10
Malformations of Cortical Development
Marilisa M. Guerreiro, MD, PhD and Maria Augusta Montenegro, MD, PhD
Section II: The Neonate
Chapter 11
Self-Limited Neonatal Epilepsy Syndromes
Maria Augusta Montenegro, MD, PhD
Chapter 12
Self-Limited (Familial) Infantile Epilepsy
Heather Pekeles, MD and Kenneth A. Myers, MD PhD
Chapter 13
Early Myoclonic Encephalopathy (Ohtahara Syndrome)
Reega Purohit, MD and Linda Laux, MD
Chapter 14
Early Myoclonic Encephalopathy
Juan Ignacio Appendino, MD and Juan Pablo Appendino, MD
Chapter 15
Hypoxic-Ischemic Encephalopathy (Neonatal Seizures)
Jeffrey J. Gold, MD, PhD
Chapter 16
Epilepsy of Infancy with Migrating Focal Seizures
Daneille DeCampo, MD and Eric Marsh MD, PhD
Section III: The Infant
Chapter 17
Febrile Seizures
Morris H. Scantlebury, MD
Chapter 18
Genetic Epilepsy with Febrile Seizures Plus (GEFS+)
Michaela Castello, MD, PhD and Aliya Frederick, MD, PhD
Chapter 19
Myoclonic Epilepsy of Infancy
Douglas R. Nordli, III, MD and Douglas R. Nordli, Jr., MD
Chapter 20
Dravet Syndrome
Douglas R. Nordli, III, MD and Douglas R. Nordli, Jr, MD
Chapter 21
Glucose Transporter-1 Deficiency Syndrome
Joerg Klepper, MD
Chapter 22
Infantile Epileptic Spasms Syndrome
Shaun A. Hussain, MD, MS
Chapter 23
Gelastic Seizures
Samiya Ahmad, MD and Yu-tze Ng, MD, FRACP
Chapter 24
Intractable Epilepsy after Herpes Simplex Encephalitis
Daniel A. Freedman, DO and Dave F. Clarke, MD
Chapter 25
Refractory Status Epilepticus
Sonali Sen, MD and James J. Riviello, Jr, MD
Chapter 26
Primary Mitochondrial Epilepsies
Russell P. Saneto, DO, PhD
Chapter 27
Tuberous Sclerosis Complex
Aimee F. Luat, MD and Harry T. Chugani, MD
Chapter 28
Sturge Weber Syndrome
Sabrina Tavella-Burka, DO and Ajay Gupta, MD
Section IV: The Child
Chapter 29
Self-Limited Epilepsy with Centrotemporal Spikes (Benign Rolandic Epilepsy)
Olivia Kim-McManus, MD
Chapter 30
Self-Limited Epilepsy with Autonomic Seizures (Panayiotopoulos Syndrome)
Korwyn Williams, MD, PhD
Chapter 31
Childhood Occipital Visual Epilepsy
Maria Augusta Montenegro, MD, PhD
Chapter 32
Photosensitive Occipital Lobe Epilepsy
Maria Augusta Montenegro, MD, PhD
Chapter 33
Childhood Absence Epilepsy
Stephane Auvin, MD, PhD, FAES
Chapter 34
Epilepsy with Myoclonic Absence
Anita M. Devlin, MBBS, MD
Chapter 35
Lennox Gastaut Syndrome
Jong M. Rho, MD
Chapter 36
Epilepsy with Myoclonic-Atonic Seizures (Doose Syndrome)
A.G. Christina Bergqvist, MD
Chapter 37
Landau Kleffner Syndrome
Frank M. C. Besag, FRCP, FRCPsych, FRCPCH
Chapter 38
Developmental/Epileptic Encephalopathy with Spike-and-Wave Activation in Sleep (D/EE-SWAS)
Kevin Chapman, MD
Chapter 39
Epilepsy with Eyelid Myoclonia (Jeavons Syndrome)
Ifrah Zawar MD and Elia Pestana Knight MD, FAES, FACNS
Chapter 40
Anti-NMDA Receptor Encephalitis
Jennifer Yang, MD and Jennifer Graves, MD, PhD, MAS
Chapter 41
Nonconvulsive Status Epilepticus
Sonali Sen, MD and James J. Riviello, Jr, MD
Chapter 42
Febrile Infection-Related Epilepsy Syndrome (FIRES)
Rima Nabbout, MD, PhD and Sara Matricardi, MD, PhD
Chapter 43
New-Onset Refractory Status Epilepticus (NORSE)
Steven Yang, DO and Jerry Shih, MD
Chapter 44
Low-Grade Developmental and Epilepsy Associated Brain Tumors
Christie Becu, MD and Angus Wilfong, MD
Chapter 45
Rasmussen's Encephalitis
Maria Augusta Montenegro, MD, PhD
Section V: The Adolescent
Chapter 46
Juvenile Myoclonic Epilepsy
Cornelia Drees, MD
Chapter 47
Epilepsy with Generalized Tonic-Clonic Seizures Alone
Kaitlin C. James and Jesus Eric Pina-Garza, MD
Chapter 48
Juvenile Absence Epilepsy
Maria Augusta Montenegro, MD, PhD
Chapter 49
New-Onset Seizure in an Adolescent Female
Mary L. Zupanc, MD
Chapter 50
Temporal Lobe Epilepsy
June Yoshii-Contreras, MD
Chapter 51
Unverricht Lundborg Disease
Mayank Verma, MD, PhD, Danielle M. Andrade, MD and Berge A. Minassian, MD, CM, FRCP(C)
Chapter 52
Reflex Seizures
Maria Augusta Montenegro
Chapter 53
Sleep-Related Hypermotor Epilepsy
Kevin Chapman, MD
Chapter 54
Psychogenic Nonepileptic Seizures
Guillermo Delgado-García, MD,MSc and Colin B. Josephson, MD, MSc, MSc, FRCP(C), CSCN (EEG)