The newest edition of the essential guide to pancreatic medicine



The fourth edition of The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery integrates the cutting-edge research of recent years to update its presentation of this fast-growing subject. It details every known disorder of the pancreas, grounding them in a thorough understanding of pancreatic function, enhanced with high quality illustration and graphs. It also includes step-by-step guidance for relevant endoscopic techniques and surgical procedures.



The Pancreas readers will also find:

New comprehensive insights into three pancreatic diseases: autoimmune pancreatitis, cystic neoplasms, and neuroendocrine tumors
An editorial team with decades of clinical and research experience in the US, Europe, and Asia
Over 500 downloadable illustrations for use in scientific presentations


The Pancreas is a foundational reference for clinicians and researchers in gastroenterology and gastrointestinal surgery.





AUTHORS



Hans G. Beger, MD, FACS (Hon.), JSS (Hon.), CSS (Hon.), Professor Emeritus of Surgery, University of Ulm, Ulm, Germany.



Markus W. Büchler, MD, FACS (Hon.), FRCS (Hon.), FASA (Hon.) Professor of Surgery, University of Heidelberg, Heidelberg, Germany.



Ralph H. Hruban, MD, Baxley Professor and Director, Department of Pathology and Director of the Sol Goldman Pancreatic Research Center, Johns Hopkins University School of Medicine, Baltimore, USA.



Julia Mayerle, MD, Professor of Internal Medicine, Gastroenterology and Hepatology, Chair Department of Medicine II, LMU Klinikum, Ludwig-Maximilians-University, Munich, Germany.



John P. Neoptolemos, MA, MB, BCHIR, MD FRCS, FMEDSCI, MAE Professor of Surgery Department of Surgery, University of Heidelberg, Heidelberg, Germany.



Tooru Shimosegawa, MD, PhD, Professor Emeritus Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.



Andrew L. Warshaw, MD, FACS, FRCSEd (Hon.), W. Gerald Austen Distinguished Professor of Surgery, Harvard Medical School, and Surgeon-in-Chief Emeritus, Massachusetts General Hospital, Boston, USA.



David C. Whitcomb, MD, PhD, Professor of Medicine, Cell Biology & Physiology, and Human Genetics, Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh and UPMC, Pennsylvania, USA.



Yupei Zhao, MD, FICS (Hon.), FACS (Hon.), FRCS (Engl) (Hon.), FCSHK (Hon.), Professor of Surgery, Department of General Surgery Peking Union Medical College Hospital, Beijing, P.R. China.


Section 1 Anatomy of the Pancreas

1 Development of the Pancreas and Related Structures

Brian Lewis and Junhao Mao

2 Anatomy, Histology, and Fine Structure of the Pancreas

Daniel S. Longnecker and Elizabeth D. Thompson

3 Congenital and Inherited Anomalies of the Pancreas

Heiko Witt and Martin Zenker



Section 2 Physiology and Pathophysiology of Pancreatic Functions

4 Physiology of Acinar Cell Secretion

Ole H. Petersen

5 Physiology of Duct Cell Secretion

Wei-Yin Lin, Paramita Sarkar, and Shmuel Muallem

6 Physiology and Pathophysiology of Function of Sphincter of Oddi

Savio George Barreto and James Toouli

7 Neurohormonal and Hormonal Control of Pancreatic Secretion

Chung Owyang and Matthew J. DiMagno

8 Regulation of Pancreatic Protein Synthesis and Growth

Maria Dolors Sans and John A. Williams

9 Fibrogenesis in the Pancreas: The Role of Pancreatic Stellate Cells

Minoti V. Apte, Romano C. Pirola, and Jeremy S. Wilson

10 Pancreatic Endocrine Exocrine Relationship

Kenichiro Furuyama and Yoshiya Kawaguchi



Section 3 Acute Pancreatitis

11 Epidemiology and Etiology of Alcohol-Induced Pancreatitis

Jeremy S. Wilson, Romano C. Pirola, and Minoti V. Apte

12 Epidemiology and Etiology of Biliary Acute Pancreatitis

Ippei Ikoma, Ko Tomishima, and Hiroyuki Isayama

13 Genetic Factors in Acute Pancreatitis

Mitchell L. Ramsey and Georgios I. Papachristou



14 The Role of the Intestine and Mesenteric Lymph in the Development of Organ Dysfunction in Severe Acute Pancreatitis

Alistair B.J. Escott, Anthony R.J. Phillips, and John A. Windsor

15 The Role of Neurogenic Inflammation in Pancreatitis

Metrah Mohammad Nader and Jami L. Saloman

16 Molecular, Biochemical, and Metabolic Abnormalities of Acute Pancreatitis

Ujjwal M. Mahajan, F. Ulrich Weiss, Markus M. Lerch, and Julia Mayerle

17 Histopathology of Acute Pancreatitis

Günter Klöppel

18 Severity Classification of Acute Pancreatitis

John A. Windsor

19 Clinical Assessment and Biochemical Markers to Objectify Severity and Prognosis

Bettina M. Rau and Claus Schäfer

20 Acute Pancreatitis Associated with Congenital Anomalies

Charlotte S. Austin, Christopher R. Schlieve, Andrew L. Warshaw, and Tracy C. Grikscheit

21 Acute Pancreatitis in Children

Mark E. Lowe and Véronique D. Morinville

22 Acute Pancreatitis Associated with Metabolic, Infections, and Drug-Related Diseases

Ali A. Aghdassi, Mats L. Wiese, Quang Trung Tran, and Markus M. Lerch

23 Radiologic Diagnosis and Staging of Severe Acute Pancreatitis

Yoshihisa Tsuji

24 Conservative Therapy of Acute Pancreatitis: Volume Substitution and Enteral and Parenteral Nutrition

Steven M. Hadley and Timothy B. Gardner

25 ICU Treatment of Severe Acute Pancreatitis

Scott R. Gunn and David C. Whitcomb

26 Clinical Course and Medical Treatment of Acute Pancreatitis Use of Antibiotics in Severe Acute Pancreatitis: Indications and Limitations

Rainer Isenmann and Mathias Wittau

27 Indications for Interventional and Surgical Treatment of Necrotizing Pancreatitis

Lily V. Saadat and Thomas E. Clancy

28 Management of Infected Necrosis: Step-Up Approach

Hester C. Timmerhuis, Marc G. Besselink, and Hjalmar C. van Santvoort

29 Management of Infected Pancreatic Necroses: An Endoscopic Approach

Todd Huntley Baron

30 Minimally Invasive Debridement and Lavage of Necrotizing Pancreatitis

Kulbir Mann and Michael G.T. Raraty

31 Open Surgical Debridement of Necrotizing Pancreatitis: Late Postoperative Morbidity and Outcome

Dongya Huang, Zipeng Lu, and Yi Miao

32 Endoscopic Treatment of Biliary Acute Pancreatitis

Ichiro Yasuda, Tsuyoshi Mukai, and Toru Ito

33 Strategies for the Treatment of Pancreatic Pseudocysts and Walled-Off Necrosis After Acute Pancreatitis: Interventional Endoscopic Approaches

Georg Beyer and Julia Mayerle

34 Pseudocysts and Walled-Off Necrosis After Acute Pancreatitis: Surgical Approach

Naohiro Sata, Masaru Koizumi, and Alan Kawarai Lefor

35 Management of Fluid Collection in Acute Pancreatitis

Georg Beyer, Simon Sirtl, Christoph Ammer-Herrmenau, and Albrecht Neesse

36 Management of Pancreatic Fistula in Acute Pancreatitis

Marta Sandini, Thilo Hackert, and Markus W. Büchler

37 Long-Term Outcome After Treatment of Acute Pancreatitis

Christin Tjaden and Thilo Hackert



Section 4 Chronic Pancreatitis

38 Definition and Classification of Chronic Pancreatitis

David C. Whitcomb

39 Molecular Understanding of Chronic Pancreatitis

Bomi Lee, Monique T. Barakat, and Sohail Z. Husain

40 Natural History of Recurrent Acute and Chronic Pancreatitis

Rohit Das, Jorge D. Machicado, and Dhiraj Yadav

41 Pediatric Recurrent Acute and Chronic Pancreatitis: Role of Pancreas Divisum

Jiri Snajdauf, Michal Rygl, Barbora Kucerova, and Natalia Petrasova

42 Clinical and Laboratory Diagnosis of Chronic Pancreatitis

Georg Beyer, Markus M. Lerch, and Julia Mayerle

43 Abdominal Imaging for the Diagnosis of Chronic Pancreatitis

Atsushi Irisawa and Akira Yamamiya

44 Endoscopic Ultrasound for Diagnosis of Chronic Pancreatitis Versus Pancreatic Cancer

J. Enrique Domínguez-Muñoz, Julio Iglesias-García, José Lariño-Noia, and Daniel de la Iglesia-García

45 Hereditary Pancreatitis and Complex Genetic Causes

Celeste Shelton Ohlsen and David C. Whitcomb

46 Epidemiology and Pathophysiology of Tropical Chronic Pancreatitis

Shailesh V. Shrikhande and Savio G. Barreto

47 CFTR-Associated Pancreatic Disease

Chee Y. Ooi and Aliye Uc

48 Alcohol and Smoking in Chronic Pancreatitis

Atsushi Masamune, Kazuhiro Kikuta, and Kiyoshi Kume

49 Idiopathic and Rare Causes of Chronic Pancreatitis

Morihisa Hirota and Tooru Shimosegawa

50 Early Chronic Pancreatitis

Kazuhiro Kikuta and Atsushi Masamune

51 Chronic Pancreatitis with Inflammatory Mass in the Pancreatic Head

Ulrich F. Wellner, Kim C. Honselmann, and Tobias Keck

52 Structural Complications: Strictures, Stones, Pseudocysts, and Vascular Complications

Xiaodong Tian, Xiaochao Guo, and Yinmo Yang

53 Nutritional Evaluation and Support: An Overview

Sinead N. Duggan and Stephen J. O'Keefe

54 Exocrine Pancreatic Insufficiency

Chris E. Forsmark

55 Bone Disease in Chronic Pancreatitis

Sinead N. Duggan

56 Diabetes from Exocrine Pancreatic Disease

Nao Fujimori, Tetsuhide Ito, and Yoshihiro Ogawa

57 Oxidative Stress and Antioxidants in Chronic Pancreatitis

Soumya Jagannath Mahapatra and Pramod Kumar Garg

58 Pain Mechanisms in Chronic Pancreatitis

Pierluigi Di Sebastiano, Fabio Francesco di Mola, Tommaso Grottola, and Rossana Percario

59 Pain Management in Chronic Pancreatitis

Louise Kuhlmann, S ren S. Olesen, and Asbj rn M. Drewes

60 Adjunctive Therapy in Chronic Pancreatitis

Anna Evans Phillips

61 Pancreatic Cancer Risks in Chronic Pancreatitis

Patrick Maisonneuve and Albert B. Lowenfels

62 Evidence of Endoscopic and Interventional Treatment of Chronic Pancreatitis and

Pseudocysts

Jörg Schirra, Simon Sirtl, Markus M. Lerch, and Julia Mayerle

63 Major Pancreatic Resection for Chronic Pancreatitis: Indication, Goals, and Limitations

Faik G. Uzunoglu and Jakob R. Izbicki

64 Pancreatic Drainage Procedures: Techniques and Results

Ulrich F. Wellner, Dirk Bausch, and Tobias Keck

65 Duodenum-Preserving Pancreatic Head Resections for Chronic Pancreatitis: Techniques and Results

Hans G. Beger, Bertram Poch, Yang Yinmo, and Waldemar Uhl

66 Total Pancreatectomy with Islet Autotransplantation

Greg Beilman, Zachary Bergman, and Melana Bellin

67 Minimally Invasive Surgical Management of Chronic Pancreatitis

Gilbert Z. Murimwa1, Matthew R. Porembka1, and Herbert J. Zeh III



Section 5 Autoimmune Pancreatitis

68 Epidemiology of Autoimmune Pancreatitis

Terumi Kamisawa

69 Molecular Immunology and Pathogenesis of Autoimmune Pancreatitis

Yoh Zen

70 Clinical Manifestation of Type 1 Autoimmune Pancreatitis

Tooru Shimosegawa

71 Clinical Manifestation of Type 2 Autoimmune Pancreatitis

Nicolò de Pretis and Luca Frulloni

72 Clinical Diagnostic Criteria for Autoimmune Pancreatitis

Tooru Shimosegawa

73 Laboratory Diagnosis of Autoimmune Pancreatitis

J.-Matthias Löhr and Miroslav Vujasinovic

74 What Is the Evidence Measuring Immune Markers

Shigeyuki Kawa, Takayuki Watanabe, and Norihiro Ashihara

75 Autoimmune Pancreatitis and IgG4-Related Disease

Kazuichi Okazaki, Tsukasa Ikeura, and Kazushige Uchida

76 Imaging Diagnosis of Autoimmune Pancreatitis

Kazuichi Okazaki, Makoto Takaoka, Tsukasa Ikeura, and Kazushige Uchida

77 Medical Management of Autoimmune Pancreatitis

Shounak Majumder and Suresh T. Chari

78 Management of Intractable Autoimmune Pancreatitis

Shounak Majumder and Suresh T. Chari

79 Long-Term Outcome After Treatment of Autoimmune Pancreatitis

Luca Frulloni and Nicolò de Pretis



Section 6 Neoplastic Tumors of the Exocrine Tissue: Benign Cystic Neoplasms of the Pancreas

80 Epidemiology of Cystic Neoplasms of the Pancreas

Shounak Majumder and Suresh T. Chari

81 Histologic Classification and Staging of Cystic Neoplasm

Noriyoshi Fukushima and Giuseppe Zamboni

82 Molecular Mechanisms of Cystic Neoplasia

Nickolas Papadopoulos and Ralph H. Hruban

83 Clinical Presentation of Pancreatic Cystic Neoplasms

Masao Tanaka

84 Evaluation of Cystic Lesions Using EUS, MRI, and CT

Anne Marie Lennon and Atif Zaheer

85 Cytologic Evaluation of Cystic Neoplasm: The Role of Liquid Biopsy

Abdulwahab Ewaz and Michelle D. Reid

86 Natural History of Cystic Neoplasm: IPMN, MCN, SCN, and SPN

Rosa Klotz, Thilo Hackert, and Markus W. Büchler

87 Surveillance or Surgical Treatment in Asymptomatic Cystic Neoplasm

Klaus Sahora and Carlos Fernández-del Castillo

88 Artificial Intelligence in the Detection and Surveillance of Cystic Neoplasms

Linda C. Chu and Elliot K Fishman

89 Oncologic Resection of IPMN and MCN: Open Approach Results

Marco Del Chiaro, Michael J. Kirsch, and Richard D. Schulick

90 Surgical Treatment of Cystic Neoplasms: Laparoscopic and Robotic Approach Results

Benedict Kinny-Köster, Christopher L. Wolfgang, Markus W. Büchler, and Thilo Hackert

91 Robotic-Assisted Resection of Cystic Neoplasms

Kimberly Kopecky and Jin He

92 Duodenum-Preserving Pancreatic Head Resection for Cystic Neoplasms of the Pancreatic Head: Indication and Limitations

Hans G. Beger and Bertram Poch

93 Pancreatic Middle Segment Resection of Cystic Neoplasms: Indications and Limitations

Calogero Iacono and Mario De Bellis

94 Tumor Enucleation for Cystic Neoplasms of the Pancreas: Indications and Limitations

Rachel C. Kim, C. Max Schmidt, and Henry A. Pitt

95 Duodenum-Preserving Pancreatic Head Resection and Local Extirpation of SPTP in Children and Adolescents: Indication and Long-Term Results

Jiri Snajdauf, Michal Rygl, Barbora Kucerova, and Natalia Petrasova

96 Management of Recurrence of Cystic Neoplasms

Anna Nie en, Christopher L. Wolfgang, Thilo Hackert, and Markus W. Büchler

97 Long-Term Outcome After Observation and Surgical Treatment of Cystic Neoplasm: What Is the Evidence?

Roberto Salvia, Giovanni Marchegiani, Giampaolo Perri, and Claudio Bassi



Section 7 Neoplastic Tumors of the Endocrine Pancreas: Neuroendocrine Tumors of the Pancreas

98 Epidemiology and Classification of Neuroendocrine Tumors of the Pancreas

J.J. Mukherjee, Kok O. Lee, and Gregory Kaltsas

99 Pathology of Neuroendocrine Neoplasms

Atsuko Kasajima and Hironobu Sasano

100 Molecular Genetics of Neuroendocrine Tumors

Nickolas Papadopoulos and Ralph H. Hruban

101 What Is the Origin of Pancreatic Endocrine Tumors?

Aurel Perren, Iacovos P. Michael, and Ilaria Marinoni

102 Clinical Manifestation of Endocrine Tumors of the Pancreas

Tetsuhide Ito, Keijiro Ueda, Nao Fujimori, and Robert T. Jensen

103 Evidence of Hormonal, Laboratory, Biochemical, and Instrumental Diagnostics of Neuroendocrine Tumors of the Pancreas

Kok O. Lee, Gregory Kaltsas, and J.J. Mukherjee

104 Pancreatic Neuroendocrine Tumors in Multiple Neoplasia Syndromes

Anja Rinke and Thomas Matthias Gress

105 Non-Functioning Pancreatic Neuroendocrine Neoplasm: Diagnosis and Management Principles

Takao Ohtsuka, Yuto Hozaka, and Hiroshi Kurahara

106 Medical and Nucleotide Treatment of Neuroendocrine Tumors of the Pancreas

Marina Tsoli and Gregory Kaltsas

107 Interventional Radiology in the Treatment of Pancreatic Neuroendocrine Tumors

Tetsuya Idichi, Hiroshi Kurahara, and Takao Ohtsuka

108 Enucleation of Benign, Neuroendocrine Tumors of the Pancreas

Frank Weber, Andreas Machens, and Henning Dralle

109 Duodenum-Preserving Pancreatic Head Resection or Local Extirpation of Neuroendocrine Tumors of the Pancreas Larger than 2 cm

Takashi Hatori

110 Individualized Surgery for Nonfunctional Pancreatic Neuroendocrine Tumors (NF-pNET) 2 cm: Indication, Surgical Principles, and Long-Term Outcome

Charles de Ponthaud, Julien De Martino, and Sébastien Gaujoux

111 Surgical Treatment of Endocrine Tumors: Major Oncologic Resection

Frank Weber, Andreas Machens, and Henning Dralle

112 The Management of Insulinoma

Keijiro Ueda, Nao Fujimori, Robert T. Jensen, and Tetsuhide Ito

113 Evidence of Medical and Surgical Treatment of Gastrinoma

Ryuichiro Doi

114 Rare Neuroendocrine Tumors of Pancreas: Management and Evidence of Surgical Treatment

Ryuichiro Doi

115 Treatment of Neuroendocrine Neoplasia of the Pancreas and Biliary Tract

Andrea Frilling, Ashley K. Clift, and Vito Cicinnati

116 Survival After Treatment of Endocrine Tumors

Zhe Cao and Taiping Zhang



Section 8 Neoplastic Tumors of Exocrine Tissue: Pancreatic Cancer

117 Epidemiology of Pancreatic Cancer

Evelina Mocci and Alison P. Klein

118 Smoking, a Risk for Pancreatic Cancer: Experimental and Clinical Data

Uwe A. Wittel, Bradley R. Hal, and Surinder K. Batra

119 Molecular Understanding of Development of Ductal Pancreatic Cancer

Jae W. Lee, Ralph H. Hruban, and Laura D. Wood

120 From Tissue Turnover to the Cell of Origin of Pancreatic Cancer

Bo Kong, Eva Thoma, and Christoph W. Michalski

121 Microbiome of Pancreatic Cancer: Involvement in Cancer Development and Chemo-/Immunotherapy

Xianjun Yu

122 Molecular Subtypes and Clinical Applications

Maarten F. Bijlsma and Peter Bailey

123 Tumor Microenvironment: Immune Cells and Immunosuppressive Functions of Carcinoma-Associated Fibroblasts and Macrophages

Tony Pang, Zhihong Xu, Chamini Perera, and Minoti V. Apte

124 Familial Pancreatic Cancer

Alison P. Klein

125 Pathology of Exocrine Pancreatic Tumors

Meredith E. Pittman and Ralph H. Hruban

126 Pancreatic Cancer: Precancerous Lesions

Michael J. Pflüger, Michaël Noë, and Lodewijk A.A. Brosens

127 Clinical History and Risk Factors of Pancreatic Cancer

Norbert Hu ser, Volker A falg, and Helmut Friess

128 The Role of Endoscopic Ultrasonography in the Diagnosis and Differential Diagnosis of Neoplastic Lesions

Yoshiki Hirooka, Senju Hashimoto, and Eizaburo Ohno

129 Radiologic Diagnosis of Pancreatic Cancer: CT, MRI

Hannah S. Recht and Elliot K. Fishman

130 Screening of Hereditary Pancreatic Cancer

Michael Goggins

131 The Role of PET in Diagnosis of Pancreatic Cancer and Cancer Recurrence

Norbert Hu ser, Volker A falg, Isabel Rauscher, and Helmut Friess

132 Tumor Markers in Pancreatic Malignancies

Shin Hamada and Atsushi Masamune

133 The Role of Laparoscopy and Peritoneal Cytology in the Management of Pancreatic Cancer

Yosuke Kasai, Kyoichi Takaori, and Etsuro Hatano

134 Clinical Assessment and Staging of Advanced Pancreatic Cancer

James M. Lindberg, Giles F. Whalen, and Jennifer LaFemina

135 Pancreatic Cancer: Indications for Resection

Akimasa Nakao and Suguru Yamada

136 Pancreatoduodenectomy for Pancreatic Cancer, Short and Long-Term Outcome After Kausch-Whipple and Pylorus-Preserving Pancreatoduodenectomy

Benedict Kinny-Köster, John L. Cameron, and Jin He

137 Left Pancreatectomy for Body and Tail Cancer

Jony van Hilst, Mohammad Abu Hilal, and Marc Besselink

138 Total Pancreatectomy: Indication and Limitations

Seiko Hirono and Hiroki Yamaue

139 Minimally Invasive Resection for Pancreatic Cancer

Patricio M. Polanco, Imad Radi, and Herbert J. Zeh

140 Robotic Resection for Pancreatic Cancer

Renyi Qin

141 Extended Radical Surgery for Pancreatic Cancer

Thilo Hackert, Anna Nie en, and Markus W. Büchler

142 Palliative Pancreatic Resection: Is it Justified?

Kira C. Steinkraus, Max Heckler, Christoph W. Michalski, and Felix J. Hüttner

143 Outcome of Patients after R0 Resection for Locally Advanced Pancreatic Cancer Combined with Hepatic Metastasectomy: Indication and Limitations

Tingbo Liang

144 Bypass Surgery for Advanced Pancreatic Cancer

Eva Thoma, Thilo Hackert, Christoph W. Michalski, and Felix J. Hüttner

145 Endoscopic and Interventional Palliation of Pancreatic Cancer

Kazumasa Nagai and Takao Itoi

146 Neoadjuvant Treatment of Pancreatic Cancer: Evidence for Treatment Effect

Robert A. Wolff

147 Locally Advanced Pancreatic Cancer: Does the Addition of Stereotactic Body Radiation Therapy to Neoadjuvant Chemotherapy Lead to a Significant Survival Improvement after R0 Resection?

Marco Del Chiaro, Michael J. Kirsch, and Richard D. Schulick

148 Adjuvant Chemotherapy in Pancreatic Cancer: First-Line and Second-Line Treatment Benefits of Survival

Kulbir Mann, Robert P. Jones, Paula Ghaneh, and John P. Neoptolemos

149 Role of Radiation Therapy for Pancreatic Cancer

Baho U. Sidiqi, Abhinav V. Reddy, Joseph M. Herman, and Amol K. Narang

150 Immunotherapy for Pancreatic Cancer: Check-Point Blockade and Vaccine Therapy

Arsen Osipov, Adrian G. Murphy, and Lei Zheng

151 Targeted Therapies for Pancreatic Cancer

Anirban Maitra

152 Precision Cancer Medicine

Grace Oh, Surajit Dhara, and Diane Simeone

153 Palliative Chemotherapy for Advanced Pancreatic Cancer: Treatment Modalities, Side Effects, and Benefits of Survival

Christoph Springfeld and Thomas Seufferlein

154 Management of Pain in Pancreatic Cancer

Annie W. Hsu, Ayodeji Omosule, and Michael Erdek

155 Management of Cancer Recurrence

Oliver Strobel, Martin Loos, and Markus W. Büchler

156 Survival and Late Morbidity after Resection of Pancreatic Cancer

Avinoam Nevler and Charles J. Yeo



Section 9 Periampullary Cancers and Tumors Other Than Pancreatic Cancer

157 Periampullary Tumors: Clinical Presentation and Diagnostic Strategies

Jon M. Harrison and Keith D. Lillemoe

158 Histology and Genetics of Cancer of the Papilla, Distal Common Bile Duct, and Duodenum

Yue Xue, Michelle D. Reid, and Volkan Adsay

159 Adenoma and Adenocarcinoma of the Ampulla of Vater: Diagnosis and Management

Sahin Coban, Omer Basar, and William R. Brugge

160 Endoscopic Treatment of Adenomas of the Ampulla of Vater: Techniques, Results, Benefits, and Limitations

Natsuyo Yamamoto and Hiroyuki Isayama

161 Surgical Treatment of Papillary and Ampullary Tumors: Management and Long-Term Results

Norbert Hüser, Volker A falg, and Helmut Friess

162 Surgical Treatment of Duodenal Cancer

Fuyuhiko Motoi

163 Surgical Treatment of Distal Cholangiocarcinoma

Shunsuke Onoe, Yukihiro Yokoyama, and Tomoki Ebata

164 Adjuvant and Palliative Chemotherapy of Periampullary Cancers

Arachchige D.N.R. Ponweera, Paula Ghaneh, and John P. Neoptolemos

165 Long-Term Survival after Resection of Periampullary Cancer

Hideyuki Yoshitomi, Masayuki Ohtsuka, and Masaru Miyazaki

Section 10 Transplantation of the Pancreas

166 Transplantation of Pancreatic Islets

Joseph Sushil Rao, Melena D. Bellin, and Bernhard J. Hering

167 Transplantation of the Pancreas

Rainer W.G. Gruessner and Angelika C. Gruessner