Biomedical Basis of Human Disease: From Research to Clinic provides information on pathophysiology/mechanisms of organ system disease and selected disorders and diseases that cause the most deaths worldwide, including but not limited to cardiovascular, respiratory, gastrointestinal and nervous systems. This information is placed within the structural context of tissue/organ, molecular and cellular biology, pathophysiology, diagnostic and treatment methods, and disease models in sections that also describe recent research examples, such as recently developed cutting-edge in vitro and in vivo biomedical science methods to bridge the bench and bedside. This text is suitable for students, researchers and practitioners in biomedicine and basic medicine.


Part I General Pathophysiology & Mechanisms of Organ System Disease 1 General Introduction to Disease Learning Objectives Disease Terminology and Concepts Causes & Risk Factors of Disease Treatment of Disease Disease Prevention and Health Promotion Chapter Bibliography Chapter Interactive Exercises 2 General Pathophysiology of Organ System Disease 2.1 Definition of Pathophysiology 2.2 Cardiovascular Disease 2.3 Respiratory Disease 2.4 Gastrointestinal Diseases 2.5 Pancreatic and Liver Disease 2.6 Neurological Disease 2.7 Endocrine disease 2.8 Urinary tract disease 2.9 Cancer Disease Chapter Bibliography Chapter Interactive Exercises Part II Disorders and Diseases of the Organ Systems 3 Disorders and Diseases of the Cardiovascular System Learning Objectives System Anatomy and Physiology Review Biomedical Research Methods/Approach Review Diagnostic Methods, Approaches and Procedures Common Cardiovascular Disease (e.g. CHD, Stroke .etc) Other Cardiovascular Disease (e.g. Congestive Heart Failure, Shock) Age-related Heart Disease (Infants, Children, Elderly) Chapter Bibliography Chapter Diseases at a Glance Chapter Interactive Exercises 4 Disorders and Diseases of the Respiratory System Learning Objectives System Anatomy and Physiology Review Biomedical Research Methods/Approach Review Diagnostic Methods, Approaches and Procedures Upper Respiratory System Diseases Lower Respiratory System Diseases Lung Cancer Age-Related Respiratory Diseases (Infants, Children, Elderly) Chapter Bibliography Chapter Diseases at a Glance Chapter Interactive Exercises 5 Disorders and Diseases of the Gastrointestinal System Learning Objectives System Anatomy and Physiology Review Biomedical Research Methods/Approach Review Diagnostic Methods, Approaches and Procedures Diseases of the Mouth and Esophagus (e.g. esophageal cancer etc) Diseases of the Stomach (e.g. stomach cancer .etc) Diseases of the Intestines Diseases of the Gallbladder and Liver (e.g. liver cancer etc) Diseases of the Pancreas (e.g. Diabetes etc) Age-Related Gastrointestinal Diseases (Infants, Children, Elderly) Chapter Bibliography Chapter Diseases at a Glance Chapter Interactive Exercises 6 Disorders and Diseases of the Nervous System Learning Objectives System Anatomy and Physiology Review Biomedical Research Methods/Approach Review Diagnostic Methods, Approaches and Procedures Trauma of the Brain and Spinal Cord Trauma Stroke and Epilepsy Cranial Nerve Disorders Neurodegenerative Diseases Congenital and Developmental Disorders Brain Cancer and Age-Related Diseases (Infants, Children, Elderly) Chapter Bibliography Chapter Diseases at a Glance Chapter Interactive Exercises Appendices A. Glossary B. Interactive Exercises C. Answers to Interactive Exercises Index