Joint and Bone: From Bench to Bedside, Volume Three, the latest release in the Stem Cell Innovation in Health and Disease series, is a timely and fascinating collection of information and new discoveries that provides a contemporary snapshot album from the fast-moving field of regenerative medicine and stem cell therapeutics. This new volume addresses the molecular players underlying iPSC formation, maintenance, and expansion and differentiation, bringing chapters that describe cutting-edge research for understanding stem cell functions in joint and bone diseases, and for developing methods to bring stem cells from bench to bedside. Each chapter includes insights ranging from the use of mouse and human organoid cultures, genetic editing in vitro and in vivo, and human iPSCs to study stem cell functions and model joint and bone diseases.


Key Features

Provides cutting-edge research needed to understand stem cell functions in joint and bone diseases
Develops processes to bring stem cells from bench to bedside
Includes up-to-date references on stem cell biology and function in the joint and bone




ABOUT THE EDITORS

Deming Jiang

Dr. Gemn Jiang is an Associate Professor at the Zhejiang University School of Medicine. Professor Jiang has committed himself to scientific research in the field of sports system injury and regeneration. He has identified a new tendon differentiation model and recovered new mechanisms of tendon differentiation, as well as fabricated a functional tendon scaffold. Based on this work, he gained YIA of the international tendon/ligament conference in 2010. He also gained the second prize of the Natural Science Award of ministry of education.
Affiliations and Expertise
Associate Professor, Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Zhejiang, China



Ahmed El-Hashash
Dr. El-Hashash is a fellow of the California Institute of Regenerative Medicine and New York University Medical School. Prof. El-Hashash worked as a senior biomedical research scientist at Mount Sinai School of Medicine of New York University and Children's Hospital Los Angeles. He was Assistant Professor and Principal Investigator of Stem Cell & Regenerative Medicine at Keck School of Medicine and Ostrow School of Dentistry of The University of Southern California. In 2016, Prof. El-Hashash joined The University of Edinburgh, Edinburgh Medical School-Zhejiang International Campus, as Tenure-Track Associate Professor and Senior Principal Investigator of Biomedicine, Stem Cell & Regenerative Medicine. Prof. El-Hashash has several breakthrough discoveries in genes/enzymes that control stem cell behavior and regenerative medicine and has published more than 25 papers in international journals and serves as an editorial board member of repute. He is the editor or author of several books on stem cell and regenerative medicine.
Affiliations and Expertise
Associate Professor of Biomedicine, Texas A & M University, College Station, Texas, USA



General Introduction

Gemn Jiang; Zhejiang University, China

1. Cutting edge research on stem cell applications in joint and bone repair and regeneration
Ahmed El-Hashash, Edinburgh University-Zhejiang

2. Stem Cell-Based Organoid culture system as innovative model of osteoarthritis and other joint/bone diseases Farshid Guilak, Washington University, USA

3. Contributions of stem cell engineering to new therapies of joint/bone diseases
Gemn Jiang; Zhejiang University, China

4. Roles of innovative genome editing technologies (e.g. CRISPR/Cas9 systems) in stem cell engineering, rheumatic diseases and other joint/bone diseases
Alekya S. Tanikella, Makenna J. Hardy, Julia T. Oxford, Boise State Univ, USA

5. Preclinical and clinical applications of iPSC technology in modeling osteoarthritis pathologies and testing drugs
R. Castro-Viñuelas; S. Díaz-Prado; University of A Coruña (UDC), Spain

6. The gold standard iPSCs in cartilage, joint and bone repair and regeneration
Cormac Murphy, Zsuzsanna Táncos, András Dinnyés; Szent Istvan Univ, Hungary

7. Mesenchymal stem cell related therapies for cartilage, joint and bone diseases
Zi Yin, Yishan Chen, Junxin Lin, Yeke Yu & Xiaotian Du, School of Basic Medicine, Zhejiang University, China

8. Advances in animal models for joint and bone diseases
Naomi Omi and Ikuko Ezawa; University of Tsukuba, Japan

9. Novel Biomaterials for stem cell engineering and bone regeneration Added chapter based on reviewer comment
Ha Y. Byun, Gyu N. Jang, Jinkyu Lee, Heungsoo Shin, Hanyang University, South Korea

10. General Discussion, Conclusion Remark and Future Direction
Ahmed El-Hashash, Edinburgh University-Zhejiang