Offering a global, multidisciplinary perspective on this life-threatening medical emergency, The Sepsis Codex provides a concise yet comprehensive look at a complex topic. Nearly 20% of global deaths are attributed to sepsis annually, nearly half of which are in children under the age of five, with low-resource settings being disproportionately affected. A "one size fits all" approach is not sufficient to meet individual patients' needs, instead requiring a therapeutic approach that considers different ages, predisposing factors, genetic traits, and more. This cutting-edge resource brings you up to date with recent medical advances in this challenging area.

Covers pathophysiology, early detection, biomarkers and diagnosis, therapies, controversies, future research, the use of AI, professional organizations and public health in sepsis.

Includes chapters on sepsis in special populations such as in pregnant women, transplanted patients, and children.

Consolidates today's available information on this timely topic into a single, convenient resource.

AUTHORS

Marcio Borges, MD, Associate Professor of Infectious Disease Balearic Islands University; Coordinator, Multidisciplinary Sepsis Unit, Critical Care Medicine, Son Llatzer University Hospital, Palma de Mallorca, Spain.
Jorge Hidalgo, MD, MACP, MCCM, FCCP, Professor of Critical Care and the Head of the Division of Critical Care, Karl Heusner Memorial Hospital in Belize, Central America; President Elect, World Federation of Societies of Critical Care and Intensive Care Medicine, Belize.
Javier Perez-Fernandez, MD, Medical Director, Critical Care Services Baptist Hospital of Miami, Florida, USA.


PART I: INTRODUCTION

1 Sepsis: Past, Present, and Futured Lessons From COVID-19 Jose-Artur Paiva and Jordi Rello

2 Sepsis Definitions: A Historical Perspective Javier Perez-Fernandez, Arlene C. Torres, and Paola Perez

3 The Epidemiology of Sepsis Jamila Hedjal



PART II: BASIC CONCEPTS

4 Sepsis Pathophysiology Maria Jimena Aleman, Luisa Cruz, Jorge Hidalgo, and Allyson Hidalgo

5 Sepsis and Microcirculation Carlos Enrique A. Orellana Jimenez

6 Genetics and Sepsis Gabriela Alvarado



PART III: DIAGNOSIS AND MONITORING

7 Early Detection and Screening Marcio Borges Sa and Rafael Zaragoza Crespo

8 Diagnosis and Monitoring of Sepsis Pietro Arina and Mervyn Singer

9 Sepsis: Molecular Diagnostics and Biomarkers John Lyons and Craig Coopersmith

10 Hemodynamic Monitoring: Current Practice and New Perspectives Christopher Lai and Jean-Louis Teboul

11 Point of Care Ultrasound in the Management of Sepsis Saad Mahdy, Ahmed F. Hegazy and Tharawt Aisa

12 New Approaches and Understanding of Sepsis Vanessa Fonseca-Ferrer, Sulimar Morales-Colon, Luis Gerena-Montano, William Rodriguez-Cintron, and Gloria M. Rodriguez-Vega

13 Sepsis Quality Indicators in the Emergency Department Luis Antonio Gorordo-Delsol and Graciela Merinos-Sanchez



PART IV: TREATMENT

14 Sepsis Treatment: Fluids Michael Mekeirele, Domien Vanhonacker and Manu L.N.G. Malbrain

15 Vasopressor Therapy in Septic Shock Rajesh Chandra Mishra, Sharmili Sinha, Reena Shah, Ahsan Ahmed and Ahsina Jahan Lopa

16 Mechanical Ventilation in Sepsis Carlos Sanchez, Orlando Perez-Nieto and Eder Zamarron

17 Extracorporeal Membrane Oxygenation for the Support of Patients With Refractory Septic Shock Jose Alfonso Rubio Mateo-Sidron

18 Antimicrobials in the Management of Sepsis Judith Jacobi

19 Kidney Support in Sepsis Javier Maynar, Helena Barrasa, Alex Martin and Fernando Fonseca

20 Hematological Support in Sepsis Zulmi Aranda, Gerhaldine Morazan and Allyson Hidalgo

21 Specific Treatment of Focus Control in Sepsis Xavier Guirao, Montserrat Juvany, Clara Centeno and Josep Maria Badia

22 Sepsis Adjunctive Therapies Javier Perez-Fernandez and Paola Perez

23 Glycemic Control and Stress Ulcer Prophylaxis Janice L. Zimmerman

24 Nutrition in Sepsis Victor Sanchez Nava



PART V: SPECIAL SETTINGS

25 Fever in Intensive Care Units Kazuaki Atagi

26 Sepsis--In the Era of Antimicrobial Resistance Rajesh Chandra Mishra, Sharmili Sinha, Reena Shah, Ahsan Ahmed and Ahsina Jahan Lopa

27 Factors Underlying Racial and Gender Disparities in Sepsis Management Ryoung-Eun Ko and Gee Young Suh

28 Sepsis in Special Populations Marie Baldisseri, Laura S. Johnson, Michael Mazzei and Mary Jane Reed

29 Comprehensive Management of Sepsis in Pediatrics Elisabeth Esteban, Juan Carlos de Carlos, Juan Ignacio Sanchez and Javier Gil Anton

30 Maternal Sepsis Luis Antonio Gorordo-Delsol, Graciela Merinos- Sanchez, Lucina Nieves-Torres and Jeanette Zuniga Escorza



PART VI: SPECIAL CONSIDERATIONS

31 Role of Preventive Measures in Sepsis Jorge Sinclair, Jorge E. Sinclair De Frias and Lorenzo Olivero

32 Value of the Protocolization and Sepsis Performance Improvement Program in Early Identification Carlos Sanchez

33 Long-Term Sequelae of Sepsis Ahmed Taha



PART VII: FUTURE OUTLOOK

34 New Diagnostic and Therapeutic Perspectives Juan Carlos Ruiz-Rodriguez, Luis Chiscano-Camon, Erika-Paola Plata Menchaca and Ricard Ferrer

35 Artificial Intelligence in Sepsis Michiel Schinkel, Ketan Paranjape, Prabath W.B. Nanayakkara and W. Joost Wiersinga