Evidence-based Nephrology provides students of nephrology and practicing clinicians with a convenient single source of clinical evidence that has been passed through an evidence-based filter. This fully revised second edition incorporates substantial new available data, updated methods of research synthesis, and a renewed focus on consumer engagement in the evaluation and management kidney disease.



This updated textbook includes twenty new chapters and three new sections, covering supportive care and patient-centered care and outcomes. In addition, every chapter that was in the first edition has been extensively updated. This new edition covers epidemiology, acute kidney injury, primary diseases of the kidney, secondary diseases of the kidney, chronic kidney disease and complications, hemodialysis, chronic kidney disease stage 5, peritoneal dialysis, supportive care, transplantation, electrolytes and acid-base disorders, and patient centered care and outcomes for both adult and for pediatric patients.



Boasting a new co-editor along with several new chapter authors and section editors, Evidence-based Nephrology is now an even better evidence-based nephrology tool, where each chapter provides a clear foundation of the topic that is supported by the best current evidence. This new edition includes broader coverage of the available evidence and addresses crucial clinical questions regarding the treatment and care of people with all stages of chronic kidney disease, including people undergoing any form of dialysis (hemodialysis or peritoneal dialysis), those requiring kidney transplantation and pediatric patients.



Evidence-based Nephrology, Second Edition, is a core resource for the evidence-based nephrology practitioner who is otherwise limited by time constraints from researching every question that may arise daily in the care of their patients.



Volume: I



Part 1: Epidemiology

1 An Introduction to the Epidemiology of Chronic Kidney Disease

2 The Surveillance and Burden of Chronic Kidney Disease

3 Progression of Chronic Kidney Disease: An Evidence-based Approach to Risk Stratification

4 Screening for Chronic Kidney Disease

5 Risk Prediction in Chronic Kidney Disease

6 Chronic Kidney Disease in Disadvantaged Populations



Part 2: Acute Kidney Injury

7 Overview / Definition, Classification and Epidemiology of Acute Kidney Disease

8 Pre-Renal Failure and Obstructive Disease

9 Hepatorenal Syndrome

10 Acute Tubular Necrosis

11 Iodinated Contrast and Acute Kidney Injury

12 Miscellaneous Etiologies of Acute Kidney Injury

13 Renal Replacement Therapy in Acute Kidney Injury



Part 3: Primary Diseases of the Kidney

14 Renal Biopsy

15 Minimal Change Disease and Focal Segmental Glomerulosclerosis in Adults

16 Membranous Nephropathy

17 IgA Nephropathy in Adults and Children

18 Membranoproliferative Glomerulonephritis

19 Autosomal Dominant Polycystic Kidney Disease

20 Urinary Tract Infections

21a Toxic Nephropathies: Environmental Agents and Metals

21b Toxic Nephropathies: Nonsteroidal Anti-Inflammatory Drugs



Part 4: Secondary Diseases of the Kidney

22 Hypertension

23 Renovascular Disease

24 Diabetic Nephropathy

25 Lupus Nephritis

26 Hemolytic Uremic Syndrome

27 Pregnancy

28 ANCA Associated Vasculitis

29 Paraprotein Associated Kidney Disorders

30 Primary Immune Complex-Mediated Membranoproliferative Glomerulonephritis and C3 Glomerulopathies : A Clinical Approach



Part 5: Chronic Kidney Disease and complications

31 Cardiovascular disease and CKD

32 Infection and CKD

33 Treatment of Anemia in Chronic Kidney Disease

34 Dyslipidemia in CKD

35 Hypertension

36 Mineral and Bone Disorder

37 Nutritional Disorders in Chronic Kidney Disease: Pathophysiology, Detection, and Treatment

38 Preparation for Dialysis

39 Choice of Hemodialysis or Peritoneal Dialysis for Kidney Replacement Therapy





Volume: II



Part 6: Hemodialysis

40 Modalities of Extracorporeal Therapy

41 Dialysis Dose and Adequacy for Hemodialysis

42 General Management of the HD patient

43 Infections in Hemodialysis Patients

44 Vascular Access



Part 7: Chronic Kidney Disease Stage 5: Peritoneal Dialysis

45 Small Solute Clearance in Peritoneal Dialysis

46 Salt and Water Balance

47 Solutions

48 Peritoneal Dialysis: Infections

49 Urgent Start

50 Catheters



Part 8: Supportive Care

51 Overview of Kidney Supportive Care

52 Symptoms

53 Prognostication in Advanced Chronic Kidney Disease

54 Advance Care Planning

55 Conservative Kidney Management and Dialysis Withdrawal



Part 9: Transplantation

56 Evaluation of the Living Donor Kidney

57 The Impact of Deceased Donor Quality and Outcomes after Kidney Transplantation

58 Early Medical and Surgical Complications After Kidney Transplantation

59 Infections after Kidney Transplantation



Part 10: Electrolytes and Acid-Base Disorders

60 Electrolyte Disorders

61 Metabolic Evaluation and Prevention of Kidney Stone Disease



Part 11: Pediatrics

62 Growth, Nutrition and Development

63 Bone Disease in Children with Chronic Kidney Disease

64 Anemia

65 Peritoneal Dialysis in Children

66 Hemodialysis

67 Urinary Tract Infections in Children

68 Henoch-Schonlein Purpura Glomerulonephritis and IgA Nephropathy in Children

69 Hereditary Nephritis in Children

70 Shigatoxin Related Hemolytic Uremic Syndrome



Part 12: Patient-centred care and outcomes

71 Shared Decision Making

72 Fatigue

73 Depression

74 Pain

75 Neurocognitive Disorders

76 Pruritus

77 Sexual Dysfunction

78 Family and Caregiver Support