This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of endocrine pathology, it incorporates the most recent clinical, pathologic, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Endocrine is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource.
SECTION 1: THYROID
NONNEOPLASTIC
4 Thyroglossal Duct Cyst
Nicole Cipriani, MD and Vania Nosé, MD, PhD
8 Ectopic Thyroid
Vania Nosé, MD, PhD
12 Solid Cell Nests
Vania Nosé, MD, PhD
16 Acute Thyroiditis
Vania Nosé, MD, PhD
20 Granulomatous Thyroiditis (de Quervain)
Vania Nosé, MD, PhD
26 Palpation Thyroiditis
Nicole Cipriani, MD and Vania Nosé, MD, PhD
28 IgG4-Related Thyroid Disease
Vikram Deshpande, MD and Vania Nosé, MD, PhD
32 Riedel Thyroiditis
Vania Nosé, MD, PhD
38 Hashimoto Thyroiditis
Vania Nosé, MD, PhD
46 Graves Disease (Diffuse Hyperplasia)
Suzana Leite, MD and Vania Nosé, MD, PhD
54 Multinodular Thyroid Hyperplasia
Vania Nosé, MD, PhD
58 Dyshormonogenetic Goiter
Vania Nosé, MD, PhD
64 Amyloid Goiter
Vania Nosé, MD, PhD
70 Adenomatous Nodules
Vania Nosé, MD, PhD and Adam Fisch, MD, PhD
76 Pigments and Crystals, Thyroid
Nicole Cipriani, MD and Vania Nosé, MD, PhD
NEOPLASTIC
FOLLICULAR CELL-DERIVED NEOPLASMS
80 Follicular Adenoma
Vania Nosé, MD, PhD and Adam Fisch, MD, PhD
88 Oncocytic (Hurthle Cell) Adenoma
Vania Nosé, MD, PhD and Peter Sadow, MD, PhD
92 Noninvasive Follicular Thyroid Neoplasm With
Papillary-Like Nuclear Features
Vania Nosé, MD, PhD and Ying-Hsia Chu, MD
102 Hyalinizing Trabecular Tumor
Nicole Cipriani, MD and Vania Nosé, MD, PhD
108 Follicular Thyroid Carcinoma
Vania Nosé, MD, PhD and Ying-Hsia Chu, MD
118 Oncocytic (Hurthle Cell) Carcinoma
Ying-Hsia Chu, MD and Vania Nosé, MD, PhD
122 Post-FNA Site Changes, Thyroid
Vania Nosé, MD, PhD and Darcy A Kerr, MD
124 Poorly Differentiated Thyroid Carcinoma
Nicole Cipriani, MD and Vania Nosé, MD, PhD
134 Anaplastic Thyroid Carcinoma
Vania Nosé, MD, PhD and Adam Fisch, MD, PhD
144 Papillary Thyroid Carcinoma
Vania Nosé, MD, PhD and Ying-Hsia Chu, MD
162 Papillary Thyroid Carcinoma, Classic Variant
Vania Nosé, MD, PhD
170 Papillary Thyroid Carcinoma, Encapsulated Follicular
Variant
Vania Nosé, MD, PhD
178 Papillary Thyroid Carcinoma, Follicular Variant,
Infiltrative
Vania Nosé, MD, PhD and Peter Sadow, MD, PhD
182 Papillary Thyroid Carcinoma, Macrofollicular Variant
Vania Nosé, MD, PhD
188 Papillary Thyroid Carcinoma, Diffuse Sclerosing
Variant
Nicole Cipriani, MD and Vania Nosé, MD, PhD
194 Papillary Thyroid Carcinoma, Oncocytic Variant
Vania Nosé, MD, PhD and Peter Sadow, MD, PhD
198 Papillary Thyroid Carcinoma, Tall Cell Variant
Vania Nosé, MD, PhD and Julie Guilmette, MD
206 Papillary Thyroid Carcinoma, Columnar Cell Variant
Vania Nosé, MD, PhD and Peter Sadow, MD, PhD
210 Papillary Thyroid Carcinoma, Clear Cell Variant
Vania Nosé, MD, PhD
212 Papillary Thyroid Carcinoma, Solid Variant
Vania Nosé, MD, PhD and Julie Guilmette, MD
216 Papillary Thyroid Carcinoma, Hobnail Variant
Vania Nosé, MD, PhD
222 Papillary Thyroid Carcinoma, Warthin-Like Variant
Vania Nosé, MD, PhD
228 Cribriform-Morular Carcinoma
Vania Nosé, MD, PhD
238 NTRK-Rearranged Thyroid Carcinoma
Peter Sadow, MD, PhD and Vania Nosé, MD, PhD
244 Kinase Fusion-Related Thyroid Carcinomas
Ying-Hsia Chu, MD and Vania Nosé, MD, PhD
C CELL-DERIVED TUMORS
252 C-Cell Hyperplasia
Vania Nosé, MD, PhD and Adam Fisch, MD, PhD
258 Medullary Thyroid Carcinoma
Vania Nosé, MD, PhD and Adam Fisch, MD, PhD
MIXED MEDULLARY AND FOLLICULAR
CELL CARCINOMA
268 Mixed Medullary and Follicular Cell Carcinoma
Vania Nosé, MD, PhD and Darcy A Kerr, MD
THYMIC TUMORS WITHIN THYROID
272 Ectopic Thymoma
Ying-Hsia Chu, MD and Vania Nosé, MD, PhD
276 Spindle Epithelial Tumor With Thymus-Like
Differentiation
Vania Nosé, MD, PhD
282 Intrathyroid Thymic Carcinoma
Vania Nosé, MD, PhD
SALIVARY GLAND-LIKE THYROID TUMORS
290 Primary Mucoepidermoid Carcinoma of Thyroid
Darcy A Kerr, MD and Vania Nosé, MD, PhD
294 Sclerosing Mucoepidermoid Carcinoma With
Eosinophilia
Vania Nosé, MD, PhD and Darcy A Kerr, MD
300 Primary Secretory Carcinoma
Darcy A Kerr, MD and Vania Nosé, MD, PhD
HEMATOLYMPHOID TUMORS
304 Lymphoma, Thyroid
Vania Nosé, MD, PhD
310 Follicular Dendritic Cell Sarcoma, Thyroid
Vania Nosé, MD, PhD and Darcy A Kerr, MD
314 Langerhans Cell Histiocytosis, Thyroid
Vania Nosé, MD, PhD and Dipti P. Sajed, MD, PhD
GERM CELL ORIGIN
318 Benign Thyroid Teratoma
Vania Nosé, MD, PhD
324 Malignant Thyroid Teratoma
Vania Nosé, MD, PhD and Julie Guilmette, MD
328 Struma Ovarii, Struma Carcinoid, and Malignant
Struma Ovarii
Vania Nosé, MD, PhD
EMBRYONAL THYROID TUMORS
336 Thyroblastoma
Vania Nosé, MD, PhD and Julie Guilmette, MD
MESENCHYMAL AND STROMAL TUMORS
342 Peripheral Nerve Sheath Tumor, Thyroid
Vania Nosé, MD, PhD and Darcy A Kerr, MD
346 Solitary Fibrous Tumor, Thyroid
Dipti P. Sajed, MD, PhD and Vania Nosé, MD, PhD
352 Paraganglioma, Thyroid
Nicole Cipriani, MD and Vania Nosé, MD, PhD
358 Leiomyoma and Leiomyosarcoma, Thyroid
Dipti P. Sajed, MD, PhD and Vania Nosé, MD, PhD
362 Angiosarcoma, Thyroid
Dipti P. Sajed, MD, PhD and Vania Nosé, MD, PhD
366 Primary Ewing Sarcoma, Thyroid
Dipti P. Sajed, MD, PhD and Vania Nosé, MD, PhD
SECONDARY TUMORS WITHIN THYROID
370 Secondary Tumors, Thyroid
Vania Nosé, MD, PhD and Darcy A Kerr, MD
MOLECULAR PATHOLOGY OF THYROID
NEOPLASMS
374 Molecular Pathology of Thyroid Neoplasms
Vania Nosé, MD, PhD and Ying-Hsia Chu, MD
PROTOCOL FOR EXAMINATION OF
SPECIMENS FROM PATIENTS WITH
CARCINOMA OF THYROID GLAND
380 Thyroid Carcinoma Protocol
Vania Nosé, MD, PhD and Julie Guilmette, MD
SECTION 2: PARATHYROID GLAND
NONNEOPLASTIC
384 Primary Chief Cell Hyperplasia
Lori A. Erickson, MD
394 Primary Clear Cell Hyperplasia
Lori A. Erickson, MD
398 Secondary Parathyroid Hyperplasia
Lori A. Erickson, MD
404 Tertiary Parathyroid Hyperplasia
Lori A. Erickson, MD
408 Chronic Parathyroiditis
Lori A. Erickson, MD
NEOPLASTIC
412 Parathyroid Adenoma
Vania Nosé, MD, PhD and Lori A. Erickson, MD
418 Parathyroid Lipoadenoma
Lori A. Erickson, MD
422 Atypical Parathyroid Tumor
Lori A. Erickson, MD
428 Parathyroid Carcinoma
Vania Nosé, MD, PhD and Lori A. Erickson, MD
434 Secondary Tumors, Parathyroid Gland
Lori A. Erickson, MD
SECTION 3: ADRENAL GLANDS
ADRENAL CORTICAL NONNEOPLASTIC
440 Adrenal Heterotopia
Arthur S. Tischler, MD
442 Adrenal Hypoplasia and Malformations
Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD
446 Adrenal Cytomegaly
Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD
448 Adrenal Cortical Hyperplasia
Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD
454 Infectious Disorders, Adrenal Glands
Arthur S. Tischler, MD and Nada A. Farhat, MD, MA, MPH
458 Autoimmune Adrenalitis
Arthur S. Tischler, MD and Nada A. Farhat, MD, MA, MPH
460 Adrenal Amyloidosis
Arthur S. Tischler, MD and Nada A. Farhat, MD, MA, MPH
464 Incidental Adrenal Nodules
Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD
468 Adrenal Cysts
Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD
474 Adrenal Nodular Hyperplasia
Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD
ADRENAL CORTICAL NEOPLASTIC
478 Nonfunctioning Adrenal Cortical Adenomas
Vania Nosé, MD, PhD
480 Aldosterone-Producing Adenomas
Vania Nosé, MD, PhD and Patricia Nogueira de Sa, MD
486 Cortisol-Producing Adenomas
Vania Nosé, MD, PhD
494 Sex Hormone-Producing Adenoma
Vania Nosé, MD, PhD and Peter Sadow, MD, PhD
496 Primary Pigmented Nodular Adrenocortical Disease
Vania Nosé, MD, PhD
502 Adrenal Cortical Oncocytoma
Vania Nosé, MD, PhD and Peter Sadow, MD, PhD
506 Adrenal Cortical Carcinoma
Vania Nosé, MD, PhD and Ying-Hsia Chu, MD
518 Adrenal Cortical Neoplasms in Children
Vania Nosé, MD, PhD and Ying-Hsia Chu, MD
ADRENAL MEDULLA AND PARAGANGLIA
526 Adrenal Medullary Hyperplasia
Vania Nosé, MD, PhD
530 Pheochromocytoma and Paraganglioma
Vania Nosé, MD, PhD, Arthur S. Tischler, MD, and Ying-
Hsia Chu, MD
540 Composite Pheochromocytoma and Composite
Paraganglioma
Vania Nosé, MD, PhD, Arthur S. Tischler, MD, and Ying-
Hsia Chu, MD
546 Neuroblastic Tumors of Adrenal Gland
Vania Nosé, MD, PhD
MESENCHYMAL AND STROMAL TUMORS
558 Myelolipoma
Vania Nosé, MD, PhD
562 Primary Adrenal Malignant Melanoma
Vania Nosé, MD, PhD
566 Primary Adrenal Benign Connective Tissue Tumor
Vania Nosé, MD, PhD
568 Primary Adrenal Angiosarcoma
Vania Nosé, MD, PhD
572 Primary Adrenal Leiomyosarcoma
Vania Nosé, MD, PhD
576 Secondary Tumors, Adrenal Glands
Vania Nosé, MD, PhD
SEX CORD STROMAL TUMORS AND OTHERS
580 Adenomatoid Tumor
Nada A. Farhat, MD, MA, MPH and Arthur S. Tischler, MD
584 Sex Cord Stromal Tumor
Vania Nosé, MD, PhD and Arthur S. Tischler, MD
PROTOCOL FOR EXAMINATION OF
SPECIMENS FROM PATIENTS WITH
CARCINOMA OF ADRENAL GLAND
588 Adrenal Cortical Carcinoma Protocol
Vania Nosé, MD, PhD
SECTION 4: PITUITARY GLAND
NONNEOPLASTIC
592 Hypophysitis, Pituitary Gland
M. Beatriz S. Lopes, MD, PhD
596 Hyperplasia, Pituitary Gland
M. Beatriz S. Lopes, MD, PhD
598 Sarcoidosis, Pituitary Gland
M. Beatriz S. Lopes, MD, PhD and Vania Nosé, MD, PhD
602 Infarction, Pituitary Gland
M. Beatriz S. Lopes, MD, PhD
604 Sheehan Syndrome, Pituitary Gland
M. Beatriz S. Lopes, MD, PhD
606 Cystic Lesions of Sellar Region
M. Beatriz S. Lopes, MD, PhD
610 Empty Sella Syndrome
M. Beatriz S. Lopes, MD, PhD
NEOPLASTIC
ANTERIOR NEUROENDOCRINE
NEOPLASMS
612 Pituitary Adenoma
M. Beatriz S. Lopes, MD, PhD and Vania Nosé, MD, PhD
618 Pituitary Carcinoma
Vania Nosé, MD, PhD and M. Beatriz S. Lopes, MD, PhD
622 Somatotroph Adenoma
M. Beatriz S. Lopes, MD, PhD
626 Lactotroph Adenoma
M. Beatriz S. Lopes, MD, PhD
630 Thyrotroph Adenoma
M. Beatriz S. Lopes, MD, PhD
634 Corticotroph Adenoma
M. Beatriz S. Lopes, MD, PhD
638 Gonadotroph Adenoma
M. Beatriz S. Lopes, MD, PhD
642 Null Cell Adenoma
M. Beatriz S. Lopes, MD, PhD
644 Plurihormonal Adenoma
M. Beatriz S. Lopes, MD, PhD
OTHER ANTERIOR PITUITARY TUMORS
648 Craniopharyngioma, Pituitary Gland
M. Beatriz S. Lopes, MD, PhD
650 Pituitary Blastoma
Vania Nosé, MD, PhD
POSTERIOR PITUITARY CNS NEOPLASMS
654 Posterior Pituitary Tumors: Pituicytoma, Spindle Cell
Oncocytoma, and Granular Cell Tumors
M. Beatriz S. Lopes, MD, PhD
658 Gangliocytoma, Pituitary Gland
M. Beatriz S. Lopes, MD, PhD
662 Neuronal Cell Tumors: Neurocytoma
M. Beatriz S. Lopes, MD, PhD
664 Secondary Tumors, Pituitary Gland
M. Beatriz S. Lopes, MD, PhD
666 Mesenchymal and Hematopoietic Tumors, Pituitary
Gland
M. Beatriz S. Lopes, MD, PhD
670 Protocol for Examination of Specimens From
Patients With Primary Pituitary Tumors
Vania Nosé, MD, PhD and M. Beatriz S. Lopes, MD, PhD
SECTION 5: ENDOCRINE PANCREAS
676 Pancreatic Neuroendocrine Neoplasms
Vania Nosé, MD, PhD
PROTOCOL FOR EXAMINATION OF
SPECIMENS FROM PATIENTS WITH
CARCINOMA OF ENDOCRINE PANCREAS
686 Pancreatic Neuroendocrine Tumor Protocol
Vania Nosé, MD, PhD
SECTION 6: ENDOCRINE SKIN
690 Merkel Cell Carcinoma
Lori A. Erickson, MD
SECTION 7: INHERITED TUMOR
SYNDROMES
700 Familial Isolated Hyperparathyroidism
Vania Nosé, MD, PhD and Lori A. Erickson, MD
704 Glucagon Cell Hyperplasia and Neoplasia
Vania Nosé, MD, PhD
708 Hereditary Pancreatic Cancer Syndrome
Daniel C. Chung, MD and Vania Nosé, MD, PhD
712 Hyperparathyroidism-Jaw Tumor Syndrome
Vania Nosé, MD, PhD and Lori A. Erickson, MD
720 Multiple Endocrine Neoplasia Type 1 (MEN1)
Vania Nosé, MD, PhD and Michelle Menon Miyake, MD
728 Multiple Endocrine Neoplasia Type 2 (MEN2)
Vania Nosé, MD, PhD and Adam Fisch, MD, PhD
736 DICER1 Syndrome
Vania Nosé, MD, PhD and Michelle Menon Miyake, MD
746 Multiple Endocrine Neoplasia Type 4 (MEN4)
Vania Nosé, MD, PhD and Michelle Menon Miyake, MD
752 PTEN-Hamartoma Tumor Syndromes
Vania Nosé, MD, PhD and Adam Fisch, MD, PhD
760 von Hippel-Lindau Syndrome
Vania Nosé, MD, PhD and Carla Martins Alberti, MD
768 Neurofibromatosis Type 1
Vania Nosé, MD, PhD and Michelle Menon Miyake, MD
776 Carney Complex
Vania Nosé, MD, PhD
784 SDH-Deficient Pheochromocytoma and
Paraganglioma
Vania Nosé, MD, PhD and Arthur S. Tischler, MD
788 Syndromic Familial Nonmedullary Thyroid Carcinoma
Vania Nosé, MD, PhD
800 Nonsyndromic Familial Nonmedullary Thyroid
Carcinoma
Vania Nosé, MD, PhD
812 McCune-Albright Syndrome
Vania Nosé, MD, PhD
818 Beckwith-Wiedemann Syndrome
Vania Nosé, MD, PhD and Patricia Nogueira de Sa, MD
SECTION 8: PARANEOPLASTIC
SYNDROMES
828 Ectopic (Paraneoplastic) Syndromes
Lori A. Erickson, MD