Neurological Complications of Systematic Cancer and Antineoplastic Therapy, Second Edition provides an expanded, updated and in-depth review of common manifestations related to neurology that occur in patients with systemic cancer. These include brain metastases, spinal cord compression, cerebrovascular events, and leptomeningeal disease. The book also discusses neurological complications related to treatments such as radiation and chemotherapy and is an essential reference for the practicing neurologist and oncologist.



Sections in this new release cover the pathophysiology and molecular biology of cancer and the metastatic phenotype, Metastatic spread to cranial and peripheral nerves and brachial and lumbosacral plexuses, Metabolic and nutritional disorders, CNS infections, Neurological complications of immunotherapy and bone marrow transplants, Neurological complications of new molecular agents and immuno-modulatory drugs, and more.





ABOUT HERBERT B. NEWTON


Dr. Newton is currently the Director of the Neuro-Oncology Center and CNS Oncology Program at the Advent Health Cancer Institute and Advent Health Orlando Campus. He recently retired as Professor of Neurology and Neurosurgery at the Ohio State University Medical Center and the James Cancer Hospital, and was the holder of the Esther Dardinger Endowed Chair in Neuro- Oncology. He trained in Neuro-Oncology with Drs. Jerome Posner and William Shapiro at Memorial Sloan-Kettering Cancer Center in New York, and since then had been in academic Neuro-Oncology for over 25 years. He has published more than 220 peer-reviewed articles and book chapters, and is the Chief Editor or Co-Editor of ten textbooks in the field of Neurology and Neuro-Oncology. In addition, he has been listed as a Best Doctor (Neurology) and Top Doctor for Cancer (Neuro-Oncology) for the past 18 years. Dr. Malkin is currently the Director of the Neuro-Oncology Program at Massey Cancer Center, and Director of the Neuro-Oncology Division, in the Department of Neurology at Virginia Commonwealth University School of Medicine. He holds the William G. Reynolds, Jr. Chair in Neuro-Oncology and is Professor of Neurology. Before his appointment at VCU, he was the Director of Neuro-Oncology and Professor of Neurology at Froedtert and the Medical College of Wisconsin. Prior to his move to Milwaukee, he was an Associate Clinical Member at Memorial Sloan-Kettering Cancer Center and Associate Clinical Professor of Neurology at Weill Cornell Medical College. He also trained in Neuro-Oncology with Drs. Jerome Posner and William Shapiro at Memorial Sloan-Kettering Cancer Center, and since then has been in academic Neuro-Oncology for over 33 years. He has published more than 100 peer-reviewed articles and book chapters and is Co-Editor of several textbooks in the field of Neuro-Oncology.



SECTION I. Metastatic Neurological Complications



1. Common symptoms at presentation of nervous system metastases

2. Neuroimaging of systemic metastatic disease

3. Nonimaging evaluation of patients with nervous system metastases

4. Biology and pathophysiology of central nervous system metastases

5. Intracranial metastases

6. Neurosurgical approaches to the treatment of intracranial metastases

7. Epidural metastasis and spinal cord compression

8. Leptomeningeal metastasis

9. Cranial nerve involvement by metastatic cancer

10. Cancer-related plexopathies



SECTION II. Nonmetastatic Neurological Complications



11. Cerebrovascular complications of malignancy

12. Metabolic and nutritional nervous system dysfunction in cancer patients

13. Central nervous system infections in cancer patients

14. Diagnosis and treatment of paraneoplastic neurological disorders



SECTION III. Neurological Complications of Specific Neoplasms



15. Neurological complications of lung cancer

16. Neurological complications of breast cancer

17. Neurological complications of melanoma

18. Neurological complications of lymphoma

19. Neurological complications of the leukemias

20. Neurological complications of systemic cancer of the head and neck

21. Neurological complications of gynecological cancers

22. Neurological complications of GI cancers

23. Neurologic complications associated with genitourinary cancer

24. Sarcoma and the nervous system

25. Neurological complications of multiple myeloma

26. Neurologic complications in the treatment of childhood malignancies



SECTION IV. Neurological Complications of Antineoplastic Therapy



27. Neurological complications of radiation therapy

28. Neurological complications of systemic cancer and antineoplastic therapy

29. Neurological complications of hematopoietic stem cell transplantation

30. Chemotherapy-induced peripheral neuropathy

31. Neurological complications of immunotherapy and monoclonal antibody therapy

32. Neurological complications of immune modulatory therapy

33. Neurological complications of steroids and of supportive care



SECTION V. Psychiatric, Pain, Psychosocial, and Supportive Care Issues



34. Psychiatric aspects of care in the cancer patient

35. Chronic cancer pain syndromes and their treatment

36. Psychosocial issues in cancer patients with neurological complications

37. Supportive care