Following up on his first book, Fundementals of Biophysics, the author, a well-known scientist in this area, builds on that foundation by offering the biologist or scientist an advanced, comprehensive coverage of biophysics. Structuring the book into four major parts, he thoroughly covers the biophysics of complex systems, such as the kinetics and thermodynamic processes of biological systems, in the first part. The second part is dedicated to molecular biophysics, such as biopolymers and proteins, and the third part is on the biophysics of membrane processes. The final part is on photobiological processes.

This ambitious work is a must-have for the veteran biologist, scientist, or chemist working in this field, and for the novice or student, who is interested in learning about biophysics. It is an emerging field, becoming increasingly more important, the more we learn about and develop the science. No library on biophysics is complete without this text and its precursor, both available from Wiley-Scrivener.

Introduction xv

PART I BIOPHYSICS OF COMPLEX SYSTEMS

I. Kinetics of Biological Processes 3

1 Qualitative Methods for Studying Dynamic Models of Biological Processes 5

2 Types of Dynamic Behavior of Biological Systems 17

3 Kinetics of Enzyme Processes 29

4 Self-Organization Processes in Distributed Biological Systems 45

II. Thermodynamics of Biological Processes 77

5 Thermodynamics of Irreversible Processes in Biological Systems Near Equilibrium (Linear Thermodynamics) 79

6 Thermodynamics of Systems Far From Equilibrium (Nonlinear Thermodynamics) 91

PART II MOLECULAR BIOPHYSICS

III. Three-dimensional Organization of Biopolymers 99

7 Three-dimensional Confi gurations of Polymer Molecules 101

8 Different Types of Interactions inMacromolecules 109

9 Conformational Energy and Three-dimensional Structure of Biopolymers 117

IV. Dynamic Properties of Globular Proteins 153

10 Protein Dynamics 155

11 Physical Models of Dynamic Mobility of Proteins 187

PART III BIOPHYSICS OF MEMBRANE PROCESSES

V. Structure-functional Organization of Biological Membranes 227

12 Molecular Organization of Biological Membranes 229

13 Conformational Properties of Membranes 247

VI. Transport of Substances and Bioelectrogenesis 261

14 Nonelectrolyte Transport 263

15 Ion Transport. Ionic Equilibria 269

16 Electrodiffusion Theory of Ion Transport Across Membranes 281

17 Induced Ion Transport 287

18 Ion Transport in Channels 295

19 Ion Transport in Excitable Membranes 319

20 Active Transport 339

VII. Energy Transformation in Biomembranes 349

21 Electron Transport and Energy Transformation in Biomembranes 351

22 Physics of Muscle Contraction, Actin-Myosin Molecular Motor 365

23 Biophysics of Processes of Intracellular Signaling 379

VIII. Electronic Properties of Biopolymers 403

24 Fundamentals of Quantum Description of Molecules 405

25 Mechanisms of Charge Transfer and Energy Migration in Biomolecular Structures 425

26 Mechanisms of Enzyme Catalysis 481

27 Energy Transformation in Primary Processes of Photosynthesis 505

28 Electron-Conformational Interactions in Primary Processes of Photosynthesis 547

X. Primary Processes in Biological Systems 579

29 Photo-conversions of Bacteriorhodopsin and Rhodopsin 581

30 Photoregulatory and Photodestructive Processes 607

Further Reading 633

Index 635