A clinically oriented handbook providing up-to-date recommendations for mastering the practical aspects of patient management for venous thromboembolism

Venous thromboembolism (VTE) is associated with high morbidity and mortality both in and out of the hospital setting, and is one of the commonest reasons for hospital attendances and admissions. Designed as a practical resource, the Handbook of Venous Thromboembolism covers the practical aspects of venous thromboembolism management in short and easily followed algorithms and tables. This important text helps physicians keep up-to-date with the latest recommendations for treating venous thromboembolism in clinic-oriented settings. Experts in fields such as the radiological diagnosis of pulmonary embolism and thrombophilia testing, give a succinct summary of the investigation, diagnosis and treatment of venous thromboembolism and include evidence-based guidelines.

With contributions from a team on internationally recognized experts, Handbook of Venous Thromboembolism is a source of information that specialists in the field can recommend to non-specialists and which the latter will be able to review to assist in their education and management of this wide-spread condition. This vital resource:

Comprises of a clinically focused handbook, useful as a daily resource for the busy physician

Offers a handbook written by an international team of specialists offering their experience on the practical aspects of venous thromboembolism management

Addresses venous thrombosis prevention, a major focus for healthcare providers

Includes coverage on controversies in the management of venous thromboembolism so clinicians can understand how experts are practicing in real scenarios

Written for hematology trainees, emergency and acute medicine physicians, junior doctors, and primary care physicians, Handbook of Venous Thromboembolism covers the basics for treating patients with venous thromboembolism and offers guidelines from noted experts in the field.

List of Contributors viii

Foreword xi

Section I Clinical Overview 1

1 Risk Factors for Venous Thromboembolism 3
Peter E. Rose

2 Management of Venous Thrombosis in the Lower Limbs 13
Dan Horner

3 Clinical Presentation of Acute Pulmonary Embolism 21
C.E.A. Dronkers, M.V. Huisman and F.A. Klok

Section II Diagnosis 27

4 Clinical Prediction Scores 29
Kerstin de Wit and Lana A. Castellucci

5 Laboratory Aspects in Diagnosis and Management of Venous Thromboembolism 35
Giuseppe Lippi and Emmanuel J. Favaloro

6 Thrombophilia Testing 49
Massimo Franchini

7 Radiological Diagnosis of Pulmonary Embolism 55
Joachim E. Wildberger and Marco Das

8 The Antiphospholipid Syndrome 60
Karen Breen

Section III Treatment 67

9 Inpatient or Outpatient Anticoagulation 69
Lauren Floyd and Jecko Thachil

10 An Anticoagulant Service in Practice 73
Kathy Macintosh, Dawn Kyle and Linda Smith

11 Point of Care Testing 86
Dianne Patricia Kitchen

12 Direct Oral Anticoagulants in the Prevention and Management of Venous Thromboembolism 94
Yen Lin Chee and Henry G. Watson

13 The Role of Thrombolysis in the Management of Venous Thromboembolism 102
Carlos J. Guevara and Suresh Vedantham

14 Inferior Vena Cava Filters in the Management of Venous Thromboembolism 114
Anita Rajasekhar and Molly W. Mandernach

Section IV Special Situations 129

15 VTE in Pregnancy 131
Catherine Nelson Piercy

16 Paediatric Venous Thromboembolism 145
Paul Monagle and Rebecca Barton

17 Cancer associated Thrombosis 153
Simon Noble

18 Venous Thromboembolism Management in Obese Patients 161
Kathryn Lang and Jignesh Patel

19 Venous Thromboembolism in Intensive Care 169
Gill Parmilan and Jecko Thachil

20 Venous Thromboembolism; a Primary Care Perspective 174
David Fitzmaurice

Section V Unusual Site Thrombosis 181

21 Cerebral Venous Thrombosis 183
Christian Weimar

22 Upper Extremity Thrombosis 192
Scott M. Stevens and Scott C. Woller

23 Management of Intra abdominal Thrombosis 205
Serena M. Passamonti, Francesca Gianniello and Ida Martinelli

24 Thrombosis in the Retinal Circulation 216
Wenlan Zhang and Paul Hahn

Section VI Long term Sequelae of VTE 229

25 Post thrombotic Syndrome 231
Andrew Busuttil and Alun H. Davies

26 Chronic Thromboembolic Pulmonary Hypertension 240
Demosthenes G. Papamatheakis and William R. Auger

27 Predicting Recurrent VTE 255
R. Campbell Tait

Section VII Controversies 263

28 Cancer Screening in Unprovoked Venous Thromboembolism 265
David Keeling

29 Sub segmental and Incidental PE to Treat or Not? 269
Jecko Thachil

30 Management of Distal Vein Thrombosis 273
Giuseppe Camporese and Enrico Bernardi

Section VIII Prevention 281

31 A Summary of the Evidence for VTE Prevention, with a Focus on the Controversies 283
Catherine Bagot

32 VTE Prevention: Real World Practice 293
Emma Gee

33 VTE Root Cause Analysis How To Do It 301
Alison Moughton, Francesca Jones and Will Lester

Index