This book gives a comprehensive insight into platelet biogenesis, platelet signal transduction, involvement of platelets in disease, the use of diverse animal models for platelet research and future perspectives in regard to platelet production and gene therapy. Being written by international experts, the book is a concise state-of-the art work in the field of platelet biogenesis, biology and research. It represents an indispensable tool for research scientists in biomedicine, vascular biology, hematopoiesis and hemostasis and specifically for scientists in platelet research, as well as for clinicians in the field of hematology and transfusion medicine.?

Table of contents (20 chapters)
Megakaryopoiesis and Platelet Biogenesis
Italiano, Joseph E.
Pages 3-22
Transcriptional Regulation of Platelet Formation: Harnessing the Complexity for Efficient Platelet Production In Vitro
Tijssen, Marloes R. (et al.)
Pages 23-60
Megakaryocytic Transcription Factors in Disease and Leukemia
Cantor, Alan B.
Pages 61-91
Impact of the Megakaryocytic Vascular Niche on Platelet Biogenesis
Schulze, Harald (et al.)
Pages 93-114
Morphogenesis of Platelets in the Circulation
Rondina, Matthew T. (et al.)
Pages 115-129
Platelet Contents
Flaumenhaft, Robert (et al.)
Pages 133-152
Signalling Pathways Regulating Platelet Biogenesis
Mazharian, Alexandra (et al.)
Pages 153-173
Rap GTPase Signaling in Platelets and Megakaryocytes
Bergmeier, Wolfgang (et al.)
Pages 175-191
Regulation of Megakaryocyte and Platelet Survival
Au, Amanda E. (et al.)
Pages 193-220
Platelet Functions Beyond Hemostasis
Kapur, Rick (et al.)
Pages 221-237
Mouse Models for Platelet Production and Function
Bender, Markus (et al.)
Pages 239-263
Fetal and Neonatal Megakaryopoiesis and Platelet Biology
Dame, Christof (et al.)
Pages 267-291
Platelets in Ischemic Stroke
Cherpokova, Deya (et al.)
Pages 293-306
Insights in Megakaryopoiesis and Platelet Biogenesis from Studies of Inherited Thrombocytopenias
Freson, Kathleen
Pages 307-326
Acquired Thrombocytopenia
Bakchoul, Tamam (et al.)
Pages 327-349
Megakaryocytes and Platelet Production During Viral Infection
Schönrich, Günther (et al.)
Pages 351-362
Diagnosis of Inherited and Acquired Platelet Disorders
Bakchoul, Tamam (et al.)
Pages 363-379
Cellular Therapies for Wiskott-Aldrich Syndrome
Braun, Christian J. (et al.)
Pages 383-398
Generating Blood from iPS Cells
Karagiannis, Peter (et al.)
Pages 399-420
Strategies for the Gene Modification of Megakaryopoiesis and Platelets
Rey, Lisette Johana Latorre (et al.)
Pages 421-460
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