Accessible and user-friendly, Cell Biology, 4th Edition, provides a strong foundation for students entering health care career paths as well as higher level research areas. Clear, readable text and high-quality, detailed illustrations help readers quickly grasp challenging content-all focusing on cellular processes without delving into molecular processes. Drs. Thomas D. Pollard, William C. Earnshaw, Jennifer Lippincott-Schwartz, and author/illustrator Dr. Graham Johnson have thoroughly updated this popular text to ensure its relevance for students in biology, biotechnology, medicine, and pathophysiology, covering key principles of cellular function and explaining how molecular defects lead to cellular dysfunction and cause human disease.



Clear, readable explanations provide a concise story about how cells function at the molecular level.


An intuitive chapter flow starts with genome organization, gene expression, and RNA processing as a foundation for understanding every aspect of cellular function and physiology.


Brings cellular biology to life for students interested in medical science by explaining how mutations in genes can compromise virtually every cellular system and predispose to human disease. Knowledge of cell biology has led to new treatments for cancer, heart failure, cystic fibrosis, and many other diseases.


Unique illustrations with realistic proportions and relationships explain every cellular process including the assembly of SARS CoV-2, the structures attaching mitotic chromosomes to microtubules, the mechanism of DNA replication and how pumps, carriers and channels orchestrate physiological processes from synaptic transmission to cellular volume regulation.


Covers exciting breakthroughs such as SMC motor proteins actively organizing chromosomal DNA, TOR kinases regulating metabolism, new types of immunotherapy for cancer treatment, mechanisms regulating fast axonal transport and their relation to neurodegenerative diseases, how completion of DNA replication sets the time for cells to enter mitosis, how a cascade of signals specifies the site of cell division, and newly understood pathways of normal and pathological cell death.


Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.




About Thomas D. Pollard


Thomas Dean Pollard is a prominent educator, cell biologist and biophysicist whose research focuses on understanding cell motility through the study of actin filaments and myosin motors. He is Sterling Professor of Molecular, Cellular & Developmental Biology and a Professor of Cell Biology and Molecular Biophysics & Biochemistry at Yale University. He was Dean of Yale's Graduate School of Arts and Sciences from 2010 to 2014, and President of the Salk Institute for Biological Studies from 1996 to 2001. Pollard is very active in promoting scientific education and research primarily through two major societies, both of which he is a past President: the American Society for Cell Biology and the Biophysical Society William Charles Earnshaw is Professor of Chromosome Dynamics at the University of Edinburgh where he has been a Wellcome Trust Principal Research Fellow since 1996. Earnshaw is an elected Fellow of the Royal Society since 2013 for his studies of mitotic chromosome structure and segregation. Before Edinburgh, he was Professor of Cell Biology and Anatomy at Johns Hopkins School of Medicine. Jennifer Lippincott-Swartz is Group Leader at the Howard Hughes Medical Institute Janelia Research Campus. Her lab uses live cell imaging approaches to analyze the spatio-temporal behaviour and dynamic interactions of molecules in cells with a special focus on neurobiology. Before Janelia, Lippincott-Swartz was a primary investigator and chief of the Section on Organelle Biology in the Cell Biology and Metabolism Branch. Her work there included a collaboration with physicists Eric Betzig and Harald Hess (now group leaders at Janelia), who proposed a new function for the photoactivatable protein. The scientists used the protein to generate photoactivatable fluorophores, or dyes, which enabled them to illuminate different sets of molecules sequentially, creating a microscope image far more detailed than previously possible. The method, called super-resolution microscopy, garnered Betzig the 2014 Nobel Prize in Chemistry. Graham Johnson is a computational biologist and Certified Medical Illustrator (CMI) with approx. 20 years of professional experience. He is Director of the Animated Cell at the Allen Institute. Before the Allen Institute, Johnson's lab in the California Institute for Quantitative Biosciences at the University of California, San Francisco worked to generate, simulate and visualize molecular models of cells. His lab's Mesoscope project and his team at Allen Institute continue this mission by uniting biologists, programmers and artists to interoperate the computational tools of science and art.





1.Introduction to Cells
2.Evolution of Life on Earth



Section II Chemical and Physical Background
3.Molecules: Structures and Dynamics
4.Biophysical Principles
5.Macromolecular Assembly
6.Research Strategies



Section III Chromatin, Chromosomes, and the Cell Nucleus
7.Chromosome Organization
8.DNA Packaging in Chromatin and Chromosomes
9.Nuclear Structure and Dynamics



Section IV Central Dogma: From Gene to Protein
10.Gene Expression
11.Eukaryotic RNA Processing
12.Protein Synthesis and Folding



Section V Membrane Structure and Function
13.Membrane Structure and Dynamics
14.Membrane Pumps
15.Membrane Carriers
16.Membrane Channels
17.Membrane Physiology



Section VI Cellular Organelles and Membrane Trafficking
18.Posttranslational Targeting of Proteins
19.Mitochondria, Chloroplasts, Peroxisomes
20.Endoplasmic Reticulum
21.Secretory Membrane System and Golgi Apparatus
22.Endocytosis and the Endosomal Membrane System
23.Processing and Degradation of Cellular Components



Section VII Signaling Mechanisms
24.Plasma Membrane Receptors
25.Protein Hardware for Signaling
26.Second Messengers
27.Integration of Signals



Section VIII Cellular Adhesion and the Extracellular Matrix
28.Cells of the Extracellular Matrix and Immune System

29.Extracellular Matrix Molecules
30.Cellular Adhesion
31.Intercellular Junctions
32.Connective Tissues



Section IX Cytoskeleton and Cellular Motility
33.Actin and Actin-Binding Proteins
34.Microtubules and Centrosomes
35.Intermediate Filaments
36.Motor Proteins
37.Intracellular Motility
38.Cellular Motility
39.Muscles



Section X Cell Cycle
40.Introduction to the Cell Cycle
41.G1 Phase and Regulation of Cell Proliferation
42.S Phase and DNA Replication
43.G2 Phase, Responses to DNA Damage, and Control of Entry Into Mitosis
44.Mitosis and Cytokinesis
45.Meiosis
46.Programmed Cell Death


Appendix

Cell SnapShots