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Unique resource for those looking to establish high impact research centers or units
Provides a historical account of the rationale, protocol development, implementation, and communication of a range of HIV prevention and treatment clinical trials conducted by CAPRISA
Highlights the innovative designs and measurement tools used by CAPRISA clinical trials
Since its inception 14 years ago, CAPRISA has conducted numerous clinical studies that have influenced international TB-HIV treatment guidelines as well as HIV prevention through innovations in the microbicide and vaccine fields. This book provides a historical account of how each of CAPRISA's high impact studies was created, developed, implemented, analysed and communicated. In doing so, the reader is taken on a journey that provides glimpses into the genesis of research ideas and how this ultimately leads to a range of HIV prevention and treatment studies that have impacted the global response to the HIV and TB epidemics.
Comprised of 5 sections, the book details the following:
HIV epidemic in South Africa and the establishment of a research centre to undertake clinical, epidemiological and laboratory research on HIV.
CAPRISA's clinical trials on HIV and HSV-2 prevention. These studies investigated the impact of tenofovir gel as topical antiretroviral pre-exposure prophylaxis (PrEP), implementation of topical PrEP through family planning clinics, conditional cash incentives for HIV prevention, HIV vaccines, and passive immunisation with broadly neutralising antibodies.
CAPRISA's research on the treatment of HIV and TB co-infection.
A review of the major scientific findings from the CAPRISA studies on acute infection and genital mucosal immunology.
Essential support activities for the conduct of clinical trials, including research laboratories and pharmacies, as well as establishing effective communication and sustainable structures for community engagement to maintain effective and respectful partnerships with participating communities. The book concludes with a chapter about the challenges facing future HIV prevention and treatment trials.
The CAPRISA Clinical Trials: HIV Treatment and Prevention is a resource for undergraduate and postgraduate students, health care providers, doctors, decision-makers and researchers who are seeking guidance and insights on clinical trials their creation, conduct and impact.

Table of contents (16 chapters)
Studies Linked to the Evolving HIV Epidemic in South Africa: Informing the CAPRISA Scientific Agenda
Abdool Karim, Quarraisha (et al.)
Pages 3-13
CAPRISA: Establishing a Research Centre to Undertake HIV Clinical Trials
Abdool Karim, Salim S. (et al.)
Pages 15-25
Overview of Clinical Trials
Grobler, Anneke
Pages 27-38
Antiretrovirals for HIV Prevention: The CAPRISA 004 Tenofovir Gel Trial
Baxter, Cheryl (et al.)
Pages 41-56
Rolling Out of Tenofovir Gel in Family Planning Clinics: The CAPRISA 008 Implementation Trial
Mansoor, Leila E. (et al.)
Pages 57-75
The Impact of Conditional Cash Transfers in Reducing HIV in Adolescent Girls and Boys (RHIVA): The CAPRISA 007 Matched Pair, Cluster Randomised Controlled Trial
Humphries, Hilton (et al.)
Pages 77-89
HIV Vaccine and Passive Immunity Trials
Garrett, Nigel (et al.)
Pages 91-104
CAPRISA 003: Timing of Antiretroviral Initiation in HIV-TB Co-infected Patients The SAPiT Trial
Padayatchi, Nesri (et al.)
Pages 107-120
Scaling up TB-HIV Integration in Public Health Clinics: Translating Research Findings into Practice
Naidoo, Kogieleum (et al.)
Pages 121-134
From Bench to Bedside: Lessons from HIV Natural History Cohort Studies
Williamson, Carolyn (et al.)
Pages 137-152
Advancing Understanding of HIV Infection in Women Through Mucosal Immunology Studies
Passmore, Jo-Ann S. (et al.)
Pages 153-166
Good Practices in the Conduct of Clinical Trials: Good Community, Pharmacy and Laboratory Practices
Gengiah, Tanuja N. (et al.)
Pages 169-189
Ethical and Legal Considerations for Realising Post-trial Access of Novel Experimental Interventions: Lessons from the CAPRISA 004 Trial
Singh, Jerome Amir
Pages 191-200
Grants Management
Swart, Marian (et al.)
Pages 201-207
Taking Science to the People: CAPRISA Communication and Media Strategies for Announcing Outcomes of Pivotal Study Findings
Maharaj, Smita
Pages 209-230
What Does the Future Hold for CAPRISA?
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