This text provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in early prostate cancer. The book reviews new data about genetic markers, transperineal mapping biopsy and mpMRI, how to apply each of these technologies in patients with elevated PSA, when a prior prostate biopsy performed by the standard TRUS method is negative and in cases where low risk disease is already diagnosed, how to differentiate those men who might harbor more aggressive disease from those who do not. Over 75% of newly diagnosed prostate cancer meets the criteria for low risk disease which has created a dilemma for both patients and clinicians. Active surveillance programs have been initiated and are reviewed. How the new technologies impact surveillance programs is addressed. Clinical stage designation is updated and a new intra-prostatic staging system is discussed. Prostate biopsy techniques utilizing transrectal ultrasound, transperineal mapping, elastography and mpMRI are compared. Finally, utilization of this new technology in the application of focal therapy is reviewed.
The Prostate Cancer Dilemma will serve as a very useful resource for physicians and researchers dealing with, and interested in this challenging malignancy. Chapters are written by experts in their fields and include the most up to date scientific and clinical information as well as links to procedural video content.

History of Prostate-Specific Antigen, from Detection to Overdiagnosis
Manley, Brandon J. (et al.)
Pages 3-16
Pathology of Prostate Cancer: What Has Changed in the Last 30 Years
Lucia, M. Scott
Pages 17-31
Clinical Risk Prediction Tools for Prostate Cancer: TNM to CAPRA Should Risk Be Redefined?
Leapman, Michael S. (et al.)
Pages 33-52
TRUS Biopsy: Is There Still a Role?
Leapman, Michael S. (et al.)
Pages 53-67
Transperineal Biopsy Technique
Stone, Nelson N. (et al.)
Pages 69-82
3D Biopsy: A New Method to Diagnose Prostate Cancer
Krughoff, Kevin (et al.)
Pages 83-91
Elastography: Can It Improve Prostate Biopsy Results?
Skouteris, Vassilios M. (et al.)
Pages 93-106
Multiparametric MRI of the Prostate as a Tool for Prostate Cancer Detection, Localization, and Risk Assessment
Bjurlin, Marc A. (et al.)
Pages 107-126
Genomic Markers
Shore, Neal D. (et al.)
Pages 127-137
Current Status of Clinical Trials in Active Surveillance
Klotz, Laurence
Pages 141-152
Focused Targeted Therapy in Prostate Cancer
Krughoff, Kevin (et al.)
Pages 153-166
Technologies and Methods in Primary Ablation with Focal Therapy
Onik, Gary
Pages 167-185
Multiparametric MRI (mpMRI): Guided Focal Therapy
Fascelli, Michele (et al.)