Cancer, which has become the second-most prevalent health issue globally, is essentially a malfunction of cell signaling. Understanding how the intricate signaling networks of cells and tissues allow cancer to thrive - and how they can be turned into potent weapons against it - is the key to managing cancer in the clinic and improving the outcome of cancer therapies. In their ground-breaking textbook, the authors provide a compelling story of how cancer works on the molecular level, and how targeted therapies using kinase inhibitors and other modulators of signaling pathways can contain and eventually cure it.
The first part of the book gives an introduction into the cell and molecular biology of cancer, focusing on the key mechanisms of cancer formation. The second part of the book introduces the main signaling transduction mechanisms responsible for carcinogenesis and compares their function in healthy versus cancer cells. In contrast to the complexity of its topic, the text is easy to read. 14 specially prepared teaching videos on key concepts and pathways in cancer signaling are available from a companion website.

Table of Contents

The role of intracellular signaling pathways in cancer development (introduction)
The cellular view
The cell cycle
Apoptosis
Communication of tumor cells with the microenvironment
Vicious cycle in the generation of osteoclastic bone metastases in mammay cancer
The molecular view
Oncogenic receptor tyrosine kinase activation
Protein kinase C
The MAP Kinase (MAPK) signaling pathway
Molecular action of TP53 in carcinogenesis
The Wnt pathway in a normal and in a tumor cell
Effects of proteinases with metalloproteinase domains (MMPs, ADAMs) on tumor progression
BCR-ABL and the philadelphia chromosome
Oxygen sensing by Hypoxia inducible factor (HIF)
SRC kinThe role of intracellular signaling pathways in cancer development (introduction)
The cellular view
The cell cycle
Apoptosis
Communication of tumor cells with the microenvironment
Vicious cycle in the generation of osteoclastic bone metastases in mammay cancer
The molecular view
Oncogenic receptor tyrosine kinase activation
Protein kinase C
The MAP Kinase (MAPK) signaling pathway
Molecular action of TP53 in carcinogenesis
The Wnt pathway in a normal and in a tumor cell
Effects of proteinases with metalloproteinase domains (MMPs, ADAMs) on tumor progression
BCR-ABL and the philadelphia chromosome
Oxygen sensing by Hypoxia inducible factor (HIF)
SRC kinase and its substrates
Dysregulated signaling proteins as starting points for cancer therapy
- BCR-ABL
- Raf kinase
- Her2
- EGF receptor
ase and its substrates
Dysregulated signaling proteins as starting points for cancer therapy
- BCR-ABL
- Raf kinase
- Her2
- EGF receptor