Features

Presents the most current research on the role of mitochondria in liver diseases
Reviews mitochondrial function and dysfunction with respect to liver disease and immune system regulation
Links cell organelle function to the function of the liver
Emphasizes the importance of liver health as essential to the health of an entire organism
Summary

" excellent, well-organized, and timely."
Lester Packer and Enrique Cardenas, University of Southern California, Los Angeles, from the Series Preface

The liver is a vital organ that is responsible for a wide range of functions, most of which are essential for survival. The multitude of functions the liver performs makes it vulnerable to a wide range of diseases. Mitochondrial dysfunction plays an important role in many liver diseases including drug-induced liver injury, alcoholic liver disease, and nonalcoholic fatty liver disease. Mitochondria in Liver Disease gathers the most current research regarding the role of mitochondria in the liver and various diseases to which it is susceptible.

The book is separated into two sections, the first of which highlights the latest developments in mitochondrial research. It includes cutting-edge topics such as the regulation of mitochondrial respiration using hydrogen sulfide and the regulation of mitochondrial fusion fission via the endoplasmic reticulum. The second section reviews the most current research on the role of mitochondria in a wide range of liver diseases. It also addresses novel topics such as the importance of liver mitochondrial constituents as biomarkers of liver injury in plasma and as regulators of the immune system.

Mitochondria in Liver Disease represents the current state of knowledge and research on mitochondrial roles in liver diseases. Written by a group of global experts, it provides an authoritative and comprehensive overview of the latest advances and methods that mark key starting points for future research.

Table of Contents

OVERVIEW OF MITOCHONDRIA

Metabolism of Superoxide Radical and Hydrogen Peroxide in the Mitochondria
H. Susana Marinho and Fernando Antunes

Energy-Redox Axis in Mitochondria: Interconnection of Energy-Transducing Capacity and Redox Status
Zhigang Liu, Harsh Sancheti, Enrique Cadenas, and Fei Yin

Signal Transduction Pathways That Regulate Mitochondrial Gene Expression
Chien-Yu Chen, Jingyu Chen, Anketse Debebe, Yang Li, and Bangyan Stiles

Transcriptional Regulation of Mitochondrial Biogenesis and Quality Control
Hagir B. Suliman and Claude A. Piantadosi

Mitochondria in Liver Disease: Regulation of Liver Mitochondrial Function by Hydrogen Sulfide
Katalin Módis, Zahra Karimi, and Rui Wang

Impact of Aging and Calorie Restriction on Liver Mitochondria
Jon J. Ramsey, José Alberto López-Domínguez, and Kevork Hagopian

Drug Delivery to Mitochondria: A Promising Approach for the Treatment of Liver Disease
Bhuvaneshwar Vaidya, Samit Shah, and Vivek Gupta

ROLE OF MITOCHONDRIA IN LIVER DISEASES

Central Role of Mitochondria in Drug-Induced Liver Injury
Lily Dara, Heather Johnson, and Neil Kaplowitz

Role of Autophagy and Mitophagy in Liver Diseases
Bilon Khambu, Hao Zhang, and Xiao-Ming Yin

Mitochondrial Dynamics, Mitophagy and Mitochondrial Spheroids in Drug-Induced Liver Injury
Jessica A. Williams, Hong-Min Ni, and Wen-Xing Ding

Biomarkers of Mitochondrial Damage in the Liver
Mitchell R. McGill and Hartmut Jaeschke

Alterations of Mitochondrial DNA in Liver Diseases
Eric A. Schon and Bernard Fromenty

Epigenetic Modifications of Mitochondrial DNA in Liver Disease: Focus on Nonalcoholic Fatty Liver Disease
Silvia Sookoian and Carlos J. Pirola

Emerging Role of Mitochondrial Dynamics in Viral Hepatitis
Seong-Jun Kim, Gulam Syed, Sohail Mohammad, Mohsin Khan, and Aleem Siddiqui

Mitochondrial Dynamics and Liver Metabolism
María Isabel Hernández-Alvarez and Antonio Zorzano

Role of JNK in Lipotoxicity in the Liver
Sanda Win, Tin Aung Than, and Neil Kaplowitz

Mitochondrial Function, Dysfunction, and Adaptation in the Liver during the Development of Diabetes
Andras Franko, Martin Hrabê de Angelis, and Rudolf J. Wiesner

Mitochondrial Dynamics and Adaptation in Alcoholic Liver Disease and Nonalcoholic Fatty Liver Disease
Jerome Garcia, Ho Leung, Bradley Blackshire, Carl Decker, Christopher Kyaw, and Derick Han

Acid Sphingomyelinase, Mitochondria, and Liver Diseases
Carmen Garcia-Ruiz and José C. Fernández-Checa

Regulation of Liver Metabolism by Sirtuins: Emerging Roles
Eric S. Goetzman