This book provides a comprehensive overview of the biological basis of renal tumors in childhood and the clinical approaches to their treatment. Recent advances in our understanding of the molecular genetics of Wilms and other renal tumors are placed in their clinical context, including the differing treatment approaches of immediate surgery or pre-operative chemotherapy. The challenges in applying this knowledge to improve risk stratification and to incorporate biologically targeted agents into front-line therapy are discussed. All of the authors are experts from Europe and North America and the book has been written specifically as an easy reference for the practising clinician and the research scientist. It lays the basis for understanding the future direction of clinical and translational research to improve outcomes in patients with childhood renal tumors and will prove indispensable for those treating or researching into these diseases.

Epidemiology of Renal Tumours of Childhood
Stiller, Charles A. (et al.)
Pages 1-17
Genetic Predisposition to Wilms Tumour
Scott, Richard H. (et al.)
Pages 19-38
Clinical Presentation
Mullen, Elizabeth (et al.)
Pages 39-52
Pathology of Renal Tumours of Childhood
Vujanic, Gordan M.
Pages 53-76
Treatment of Wilms Tumor in the Children's Oncology Group
Fernandez, Conrad
Pages 77-99
Treatment of Wilms Tumour: The SIOP Approach
Furtwängler, Rhoikos (et al.)
Pages 101-118
Treatment of Relapsed Wilms Tumor
Spreafico, Filippo (et al.)
Pages 119-131
Imaging
Khanna, Geetika (et al.)
Pages 133-152
Biological Prognostic Factors in Wilms Tumors
Pritchard-Jones, Kathy (et al.)
Pages 153-166
Molecular-Targeted Therapy for Pediatric Renal Tumors
Geller, James I. (et al.)
Pages 167-186
Surgical Consideration for Wilms' Tumors and Other Neoplastic Renal Lesions
Ehrlich, Peter F. (et al.)
Pages 187-206
Radiotherapy for Wilms' Tumour and Other Childhood Renal Cancers
Gaze, Mark N. (et al.)
Pages 207-227
Late Effects and QOL Chapter
Levitt, Gill A. (et al.)
Pages 229-247
Non-Wilms Pediatric Renal Tumors
Dome, Jeffrey S. (et al.)
Pages 249-269
Wilms Tumour in Countries with Limited Resources
Metzger, Monika (et al.)