n the past 30 years, gastroesophageal and reflux disease (GERD) has become an important area of clinical medicine. GERD has gradually become associated with other common but unexplained disorders. These conditions have been designated as the extraesophageal manifestations of GERD.

Dr. Anthony J. DiMarino, Jr. and Dr. Sidney Cohen and their contributors have written Extraesophageal Manifestations of GERD with the purpose to identify associations with conditions like hoarseness, laryngeal cancer, sleep disorders, and dental caries, and to explore possible causation and mechanisms of disease or possible noncausal relationships.


The extraesophageal disorders have become widely accepted in clinical practice. The evidence supporting the pathogenesis of these conditions falls into three major categories: guilt by association, observed mechanistic studies, and therapeutic response to treatment.

Inside the pages of Extraesophageal Manifestations of GERD the reader will find recognition and balance in treating patients with common symptom-based disorders. Final resolution of some of the controversies inherent in these associations may require advanced diagnostic tools and advanced pharmacological therapies.

With chapters written by experts in the fields of medicine, pediatrics, otolaryngology, and dentistry, Extraesophageal Manifestations of GERD will be a must have for gastroenterologists, internal medicine residents, surgeons, otolaryngologists, and pediatricians.

Dedication
Acknowledgments
About the Editors
Contributing Authors
Introduction


Chapter 1 Extraesophageal Reflux: Definition and Pathophysiology
Vikneswaran Namasivayam, MBBS, MRCP and David A. Katzka, MD

Chapter 2 The Evaluation of Typical GERD
John O. Clarke, MD and Donald O. Castell, MD

Chapter 3 Pulmonary Manifestations of GERD: Controversies and Consensus
Lindsey B. Roenigk, MD and Susan M. Harding, MD

Chapter 4 Ear, Nose, and Throat Manifestations of GERD

An Otolaryngologist's Perspective
Joseph R. Spiegel, MD

A Gastroenterologist's Perspective
Lisa S. Cassani, MD and Michael F. Vaezi, MD, PhD, MSc

Editorial: Point Counterpoint
Anthony J. DiMarino Jr, MD and Sidney Cohen, MD

Chapter 5 Sleep Disturbance and Esophageal Reflux
Christine Herdman, MD; Dina Halegoua-DeMarzio, MD; Sidney Cohen, MD; and Anthony J. DiMarino Jr, MD

Chapter 6 GERD and Oral Manifestations
Mabi Singh, DMD, MS; Britta Magnuson, DMD; and Athena Papas, DMD, PhD

Chapter 7 Extraesophageal Manifestations in the Pediatric Population
Joan S. Di Palma, MD; Sheeja K. Abraham, MD; and Rebecca O. Ramirez, MD, FAAP

Financial Disclosures
Index