The clinical applications of diffusion-weighted MR imaging (DW-MRI) in the body are rapidly evolving. This volume highlights state-of-the-art techniques for performing DW-MRI measurement in the body and addresses important practical issues. Key points are highlighted that will help radiologists and technologists to acquire high-quality images for disease assessment and to adapt the technique to their own clinical practice or research. The major clinical applications of DW-MRI in the body, both oncological and non-oncological, are extensively illustrated, providing readers with a broad insight into the growing uses of the technique. The final section addresses future developments, considering the potential importance of the technique in relation to drug development and the ways in which DW-MRI might be combined with other functional imaging techniques to further improve disease assessment.

Principles and Background . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
1 Principles of Diffusion-Weighted Imaging (DW-MRI)
as Applied to Body Imaging . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
Thomas L. Chenevert
2 Techniques and Optimization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19
David J. Collins and Matthew Blackledge
3 Qualitative and Quantitative Analyses: Image Evaluation
and Interpretation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33
Dow-Mu Koh
Non-Oncological Applications in the Body . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49
4 MR Neurography: Imaging of the Peripheral Nerves . . . . . . . . . . . . . . . . . . . . . . 51
Taro Takahara and Thomas C. KweE
5 Evaluation of Organ Function . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69
Frederik de Keyzer and Harriet C. Thoeny
6 DW-MRI Assessment of Diffuse Liver Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85
Jignesh Patel and Bachir Taouli
Oncological Applications in the Body . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 95
7 DW-MRI for Disease Detection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 97
Dow-Mu Koh
8 DW-MRI for Disease Characterization in the Abdomen . . . . . . . . . . . . . . . . . . . . . . . . 117
Ali Muhi and Tomoaki Ichikawa
9 DW-MRI for Disease Characterization in the Pelvis . . . . . . . . . . . . . . . . . . . . . . . . . . . . 143
Masoom A. Haider, Yasaman Amoozadeh, and Kartik S. Jhaveri
10 DW-MRI Assessment of Cancer Response to Chemoradiation . . . . . . . . . . . . . . . . . 157
Brian D. Ross, Craig J. Galbán, and Alnawaz Rehemtulla
X Contents
11 DW-MRI Assessment of Treatment Response
to Minimally Invasive Therapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175
Eleni Liapi and Ihab R. Kamel
12 Evaluation of Lymph Nodes Using DW-MRI . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 187
J. M. Froehlich and Harriet C. Thoeny
13 Evaluation of Malignant Bone Disease Using DW-MRI . . . . . . . . . . . . . . . . . . . . . . . . . 207
K. Nakanishi and A. Gutzeit
14 Diffusion-Weighted Whole-Body Imaging with Background
Body Signal Suppression (DWIBS) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 227
Taro Takahara and Thomas C. Kwee
Future Developments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 253
15 Multifunctional MR Imaging Assessments: A Look into the Future . . . . . . . . . . . . 255
Anwar Padhani
16 The Potential of DW-MRI as an Imaging Biomarker in Clinical Trials . . . . . . . . . 281
Andy Dzik-Jurasz and Phil Murphy
Subject Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 293
List of Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 297