Improvements in the detection of fetal and neonatal brain injuries, advances in our understanding of the pathophysiology, cellular and molecular bases of encephalopathy, and new treatment options have all combined to produce significant changes in the management of neonatal brain disorders in the past few years.

This new edition of Fetal and Neonatal Brain Injury brings the reader fully up to date with all advances in clinical management and outcome assessment. New material includes pregnancy-induced hypertension, HELLP syndrome and chronic hypertension, complications of multiple gestation, neurogenic disorders of the brain, neonatal stroke and much more. An expanded, highly illustrated chapter on structural and functional imaging of the fetal and neonatal brain is also included. An outstanding international team of highly experienced neonatologists and maternal-fetal medicine clinicians have produced a practical, authoritative clinical text that gives clear management advice to all clinicians involved in the treatment of these patients.

Table of contents:
Section 1 Epidemiology, pathophysiology, and pathogenesis of fetal and neonatal brain injury
1 Neonatal encephalopathy: epidemiology and overview
2 Mechanisms of neurodegeneration and therapeutics in animal models of neonatal hypoxic ischemic encephalopathy
3 Cellular and molecular biology of hypoxic ischemic encephalopathy
4 The pathogenesis of preterm brain injury

Section 2 Pregnancy, labor, and delivery complications causing brain injury
5 Prematurity and complications of labor and delivery
6 Risks and complications of multiple gestations
7 Intrauterine growth restriction
8 Maternal diseases that affect fetal development
9 Obstetrical conditions and practices that affect the fetus and newborn
10 Fetal and neonatal injury as a consequence of maternal substance abuse
11 Hypertensive disorders of pregnancy
12 Complications of labor and delivery
13 Fetal response to asphyxia
14 Antepartum evaluation of fetal well-being
15 Intrapartum evaluation of the fetus

Section 3 Diagnosis of the infant with brain injury
16 Clinical manifestations of hypoxic ischemic encephalopathy
17 The use of EEG in assessing acute and chronic brain damage in the newborn
18 Neuroimaging in the evaluation of pattern and timing of fetal and neonatal brain abnormalities
19 Light-based functional assessment of the brain
20 Placental pathology and the etiology of fetal and neonatal brain injury
21 Correlations of clinical, laboratory, imaging, and placental findings as to the timing of asphyxial events

Section 4 Specific conditions associated with fetal and neonatal brain injury
22 Congenital malformations of the brain
23 Neurogenetic disorders of the brain
24 Hemorrhagic lesions of the central nervous system
25 Neonatal stroke
26 Hypoglycemia in the neonate
27 Hyperbilirubinemia and kernicterus
28 Polycythemia and fetal maternal bleeding
29 Hydrops fetalis
30 Bacterial sepsis in the neonate
31 Neonatal bacterial meningitis
32 Neurological sequelae of congenital perinatal infection
33 Perinatal human immunodeficiency virus infection
34 Inborn errors of metabolism with features of hypoxic ischemic encephalopathy
35 Acidosis and alkalosis
36 Meconium staining and the meconium aspiration syndrome
37 Persistent pulmonary hypertension of the newborn
38 Pediatric cardiac surgery: relevance to fetal and neonatal brain injury

Section 5 Management of the depressed or neurologically dysfunctional neonate
39 Neonatal resuscitation: immediate management
40 Improving performance, reducing error, and minimizing risk in the delivery room
41 Extended management following resuscitation
42 Endogenous and exogenous neuroprotective mechanisms after hypoxic ischemic injury
43 Neonatal seizures: an expression of fetal or neonatal brain disorders
44 Nutritional support of the asphyxiated infant

Section 6 Assessing outcome of the brain-injured infant
45 Early childhood neurodevelopmental outcome of preterm infants
46 Cerebral palsy: advances in definition, classification, management, and outcome
47 Long-term impact of neonatal events on speech, language development, and academic achievement
48 Neurocognitive outcomes of term infants with perinatal asphyxia
49 Appropriateness of intensive care application
50 Medicolegal issues in perinatal brain injury