The only textbook written for undergraduates by teachers of the course, this bestseller presents the most current concepts in an experimental context, conveying the excitement of scientific discovery, and highlighting important advances while providing unsurpassed pedagogical support for the first-time learner. The new edition is thoroughly updated, including most notably the new chapter on innate immunity.

Table of Contents



Part I Introduction
1. Overview of the Immune System
2. Cells and Organs of the Immune System
New! 3. Innate Immunity

Part II Generation of B-Cell and T-Cell Receptors
4. Antibodies and Antigens
5. Organization and Expression of Immunoglobulin Genes
6. Antigen-Antibody Reactions: Principles and Applications
7. The Complement System
8. The Major Histocompatibility Complex and Antigen Presentation
9. T-Cell Receptor
10. T-Cell Maturation, Activation, and Differentiation
11. B-Cell Generation, Activation and Differentiation

Part III Immune Effector Mechanisms
12. Cytokines
13. Leukocyte Activation and Migration
14. Cell-Mediated Cytotoxic Responses
15. Hypersensitivity Reactions

Part IV The Immune System in Health and Disease
16. Tolerance and Autoimmunity
17. Transplantation Immunology
18. Immune Responses to Infectious Diseases
19. Vaccines
20. AIDS and Other Immunodeficiencies
21. Cancer and the Immune System
22. Experimental Systems