This title's practical and applicable information makes it a perfect clinical resource for the practicing neurologist. While it is not a case-based text - it focuses more on common problems and chronic problems that require long-term management - it provides guidelines and pathways through the decision-making process that prove invaluable in practice. With an expanded section on multiple sclerosis, updated and revised information in nearly every section, and decision-approach summary tables at the beginning of every chapter, the second edition promises to stay in the limelight as the definitive text for outpatient neurologists and internists.

What's New

Features an expanded section on multiple sclerosis, with in-depth discussions on the clinical issues surrounding the disease.
Discusses the latest molecular genetic studies, including new information on the progressive ataxias Alzheimer's disease Huntington's disease mitochondrial disorders and familial stroke and headache syndromes.
Reports on the results of recent clinical studies on asymptomatic carotid atherosclerosis and symptomatic carotid endarterectomy.
Includes the latest methods for treating stroke seizures multiple sclerosis migraine Parkinson's disease amyotrophic lateral sclerosis and Alzheimer's disease.
Presents a summary table at the beginning of each chapter, highlighting the authors' approaches to various problems of diagnosis and management.

Contents

Part I: Principles of Ambulatory Neurology and the Approach to Clinical Problems
Section 1: Principles of Diagnosis: The General
Approach to Neurologic Diagnosis

1. Neurologic History and Examination

Section 2: Principles of Diagnosis: Common Presenting Symptoms and Findings
2. Weakness
3. Movement Disorders
4. Gait Impairment and Falling
5. Sensory Loss and Paresthesias
6. Disorders of the Eyes and Eyelids
7. Facial Palsy
8. Dizziness and Vertigo
9. Hearing Loss and Tinnitus
10. Disorders of Taste and Smell
11. Dysarthria and Dysphagia
12. Transient Events
13. Respiratory Dysfunction
14. Autonomic Dysfunction
15. Sexual Dysfunction
16. Disorders of Cerebrospinal Fluid Flow
17. Traumatic Brain Injury

Section 3: Principles of Diagnosis: Special Tests
18. Laboratory Evaluation
19. Molecular Diagnosis
20. Electrophysiology: Electroencephalography and Evoked Potentials
21. Electrophysiology: Nerve Conduction Studies and Electromyography
22. Neuroimaging: Radiology, Magnetic Resonance Imaging, Positron Emission Tomography, and Single-Photon Emission Computed Tomography
23. Biopsy of the Brain
24. Biopsy of Nerve and Muscle

Section 4: Principles of Treatment
25. Pharmacology of Commonly Used Drugs
26. Therapeutic Plasma Exchange
27. Rehabilitation of Neurologic Disability

Part II: Cerebrovascular Disease
Section 1: General aspects of Cerebrovascular Disease
28. Epidemiology and Stroke Risk Factors
29. Neurodiagnostic Testing

Section 2: Common Pathogeneses of Stroke
30. Atherothrombotic Cerebral Infarction
31. Cerebral Embolism
32. Lacunar Infarction
33. Intracerebral Hemorrhage
34. Subarachnoid Hemorrhage
35. Vascular Malformation

Section 3: Less Common Causes of Stroke
36. Stroke in Young Adults
37. Coagulation-Related Causes of Stroke
38. Illicit Drugs and Stroke

Section 4: Clinical Features and Management of
Cerebrovascular Disease
39. Cardinal Clinical Features of Ischemic Cerebrovascular Disease in Relation to Vascular Territories
40. Differential Diagnosis of the Major Stroke Subtypes
41. Common Vascular Problems in Office Practice
42. Current Treatment Strategies for Cerebrovascular Diseases

Part III: Immune and Infectious Disease
Section 1: Immune-Mediated Disease
43. Pathophysiology and Clinical Features of Multiple Sclerosis
44. Immunotherapy of Multiple Sclerosis
45. Multiple Sclerosis: Management of Disease Complications
46. Optic Neuritis
47. Transverse Myelitis
48. Acute Disseminated Encephalomyelitis

Section 2: Infectious Diseases
49. Approach to the Patient with Central Nervous System Infection
50. Bacterial Meningitis
51. Brain and Spinal Abscess
52. Tuberculosis
53. Leprosy
54. Brucellosis
55. Legionellosis
56. Tetanus

Spirochetal Infections
57. Neurosyphilis
58. Lyme Disease
59. Leptospirosis

Fungal and Parasitic Infections
60. Fungal Infections
61. Cysticercosis
62. Trichinosis
63. Toxoplamosis

Viral Infections
64. Viral Meningitis and Encephalitis
65. Herpes Simplex Encephalitis
66. Varicella-Zoster Virus Infection
67. Cytomegalovirus Infection
68. Epstein-Barr Virus Infection
69. Poliomyelitis
70. Measles and Subacute Sclerosing Panencephalitis
71. Progressive Multifocal Leukoencephalopathy
72. Rabies
73. Lymphocytic Choriomeningitis
74. Rubella
75. HIV Infection and Diseases of the Brain
76. HIV Infection and Diseases of the Spinal Cord, Nerve Roots, Peripheral Nerves, and Muscles
77. HTLV-1 Infection

Other Infections and Mimickers
78. Chronic and Recurrent Noninfectious Meningitis
79. Prion Diseases
80. Rickettsial Infections of the Nervous System
81. Mycoplasma Infections

Part IV: Spinal Cord and Peripheral Neuromuscular Disease
82. Clinical Approach to Disease of the Spinal Cord
83. Syringomyelia and Related Conditions
84. Spondylosis and Disk Disease
85. Vascular Disease of the Spinal Cord

Section 2: Motor Neuron Disease
86. Amyotrophic Lateral Sclerosis
87. Spinal Muscular Atrophy
88. Postpolio Syndrome
89. Atypical Motor Neuron Disease

Section 3: Diseases of Peripheral Nerve
90. Approach to and Classification of Peripheral Neuropathy
91. Radiculopathies and Plexopathies
92. Inflammatory Demyelinating Polyneuropathies
93. Diabetic Neuropathy
94. Metabolic Neuropathy
95. Infectious and Granulomatous Neuropathy
96. Dysproteinemic Polyneuropathy
97. Neuropathies in Connective Tissue Diseases
98. Toxic Peripheral Neuropathies
99. Drug - Induced Peripheral Neuropathies
100. Inherited Neuropathies
Common Entrapment and Compression Neuropathies of the Upper Extremity
101. Common Entrapment and Compression
Neuropathies of the Lower Extremity
102. Common Entrapment and Compression
Neuropathies of the Medium Extremity

Section 4: Diseases of Neuromuscular Transmission
103. Myasthenia Gravis
104. Lambert-Eaton Myasthenic Syndrome
105. Toxic and Metabolic Disorders of the
Neuromuscular Dystrophies

Section 5: Diseases of Muscle
106. Approach to Patients with muscle
Disorders
107. Muscular Dystrophies
108. Inflammatory Myopathies
109. Endocrine, Nutritional, and DrugInduced Myopathies
110. Metabolic Myopathies
111. Congenital Myopathies
112. Myotonia and Periodic Paralysis
113. Abnormal Muscle Activity

Part V: Movement Disorders
Section 1: Parkinson's Disease and Parkinson's-like Syndromes
114. Parkinson's Disease: Recognition,
Diagnosis, and Measurement
115. Initial Therapy of Parkinson's Disease
116. Management of Motor Response
Fluctuations of Parkinson's Disease
117. Surgical Therapy of Parkinson's Disease
118. Mental Changes in Parkinson's Disease
119. Multiple System Atrophy: Striatonigral
Degeneration and Shy-Drager Syndrome
120. Progressive Supranuclear Palsy
121. Diffuse Lewy Body Disease
122. Corticobasal Ganglionic Degeneration
123. Secondary Parkinsonism

Section 2: Non-Parkinsonian Movement Disorders
124. Spinocerebellar Ataxias
125. Tremors
126. Huntington's Disease
127. Tardive Dyskinesia and Other Drug-
Related Movement Disorders
128. Primary and Secondary Generalized
Dystonias
129. Focal Dystonia: Treatment with Botulinum Toxin
130. Occupational Cramp
131. Tics and Tourette's Syndrome
132. Myoclonus
133. Movement Disorders in Sleep and
Restless Leg Syndrome
134. Stiff-Man Syndrome

Part VI: Behavioral Neurology and Epilepsy
Section 1: Behavioral Neurology
135. Examining Mental State
136. Differential Diagnosis of Dementia
137. Alzheimer's Disease and Related
Disorders
138. Confusional States and Metabolic
Encphalopathy
139. Speech and Language Disorders
140. Higher-Order Visual Impairment
141. Disorders of Memory
142. Learning Disabilities in Children
143. Learning Disabilities and Attention Deficit Disorder in Adults

Section 2: Epilepsy
144. Epilepsy in Children
145. Diagnosis and Classification of Epilepsy
146. Medical Treatment of Seizures
147. Status Epilepticus
148. Surgical Treatment of Epilepsy
149. Epilepsy and Behavior

Section 3: Disorders of Sleep
150. Disorders of Sleep

Section 4: Psychiatric Issues in Neurologic Practice
151. Psychiatric Issues in Neurologic Practice
152. Psychosocial Issues in Dementia and
Epilepsy
153. Medico-Legal Issues of Competence

Part VII: Neuro-Oncology
Section 1: Brain Tumors: General Aspects
154. Classification, Epidemiology, and Etiology of Brain Tumors
155. Clinical Presentation and Diagnosis Brain Tumors
156. General Principles of Management of
Patients with Brain Tumors

Section 2: Specific Tumor Types
157. Low-Grade Gliomas
158. Optic Pathway and Hypothalamic Gliomas
159. Brainstem Gliomas
160. Malignant Gliomas
161. Primary Central Nervous System Lymphoma
162. Meningiomas
163. Pituitary Tumors
164. Craniopharyngiomas
165. Acoustic Neuroma
166. The Neurofibromatoses
167. Skull Base Tumors
168. Ependymomas
169. Medullobastomas
170. Pineal Tumors
171. Uncommon Brain Tumors and Intracranial Cysts
172. Brain Metastases

Section 3: Spinal Cord Tumors
173. Spinal Cord Tumors

Section 4: Neurologic Complications of Systemic
Cancer
174. Metastatic Epidural Spinal Cord
Compression
175. Neoplastic Meningitis
176. Neurologic Complications of Chemotherapy
177. Neurologic Complications of Radiotherapy
178. Paraneoplastic Syndromes
179. Neurologic Pain Syndromes in Cancer Patients
180. Neurologic Complications of Bone Marrow Transplantation
181. Neurologic Complications of Lymphoma
182. Neurologic Complications of Leukemia
183. Neurologic Complications Lung Cancer
184. Neurologic Complications of Breast Cancer

Part VIII: Neurology in General Medicine
Section 1: Cardiology and Cardiac Surgery
185. Neurologic Complications of Cardiac Surgery
186. Neurologic Complications of Cardiac Catheterization
187. Myocardial Damage and Cardiac
Arrhythmias
188. Neurologic Complications of Infective
Endocarditis
189. Hypertensive Encephalopathy and
Eclampsia
190. Aortic Dissection

Section 2: Pulmonary Disorders
191. Neurosarcoidosis

Section 3: Nephrology and Urology
192. Neurologic Manifestations of Renal Failure and Dialysis
193. Neurologic Manifestations of Electrolyte Disorders

Section 4: Gastroenterology and Hepatology
194. Neurologic Effects of Malabsorption and Vitamin Deficiency
195. Hepatic Encephalopathy

Section 5: Hematology
196. Neurologic Complications of Sickle Cell
Disease

Section 6: Endocrinology and Metabolism
197. Neurologic Manifestations of the Porphyrias
198. Lysosomal Storage Diseases
199. Diagnosis and Management of Mitochondrial Diseases

Section 7: Toxins and Drug Effects
200. Neurologic Complications of Alcoholism
201. Drug Dependence
202. Neurologic Complications of Commonly Prescribed Drugs
203. Clinical Manifestations of Neurotoxic
Exposure to Metals

Section 8: Organ Transplantation
204. Neurologic Complications of Organ
Transplantation

Section: 9 Rheumatology
205. Neurologic Manifestations of Rheumatic
Diseases

Part IX: Headache and Pain
Section 1: General Aspects of Headache
206. Anatomy and Physiology of Headache
207. Approach to the Patient with Headache
208. Classification and Differential Diagnosis of Headache

Section 2: Headache Syndromes and Their Treatment
209. Migraine With and Without Aura
210. Migraine Pathogenesis
211. Pharmacologic Treatment of Migraine
212. Chronic Daily Headache
213. Cluster Headache and Paroxysmal
Hemicrania
214. Psychological Evaluation and Treatment of Headache

Section 3: Special Headache Problems
215. Posttraumatic Headache
216. Exertional Headache
217. Menstruation, Pregnancy, and Menopause
218. Neuroimaging in Headache

Section 4: General Aspects of Pain
219. Anatomy and Physiology of Pain
220. Approach to the Patient with Chronic Pain
221. Addiction and Detoxification in Chronic Pain

Section 5: Generalized and Regional Pain Syndromes
222. Myofascial Pain Syndromes
223. Neuropathic Pain
224. Orofacial Pain
225. Neck and Arm Pain
226. Low Back and Leg Pain

Section 6: Treatment of Pain
227. Pharmacologic (Analgesic) Treatment of
Pain
228. Physical Therapy and Transcutaneous
Electrical Nerve Stimulation
229. Psychological Evaluation and Treatment of Chronic Pain
230. Neurosurgical Treatment and Implantable Devices