The most common reason for a renal consult in a hospitalized patient is acute renal failure (ARF). This new companion book to Brenner and Rector's The Kidney provides the reader with the complete information necessary to understand, diagnose, and treat this serious and challenging condition. The first part of the book describes recent progress in the understanding of the pathophysiology of ARF, explaining the tremendous strides in the molecular and cellular aspects of cell injury and recovery. The remainder (and majority) of the text emphasizes the clinical spectrum and management of the different disease processes causing ARF. In these chapters, ARF is discussed in terms of its many associated disease processes such as pigment nephropathy, burns, infectious disease, and gastrointestinal and liver disease. This format allows for rapid referral and an in-depth understanding of all clinical aspects of ARF, including its most important aspect of management: to prevent the disease from becoming chronic, ultimately leading to dialysis and then transplantation.

Features

Provides the reader with a single-volume, authoritative, clinically oriented resource on ARF.
Offers an in-depth analysis of recent advances in scientific and clinical aspects of acute renal failure (ARF).
Covers the most recent advances in therapy, and emphasizes diagnosis, management, and prognosis.
Integrates basic science with clinical diagnosis and treatment throughout.
Describes in detail the mechanisms underlying the development of ARF and highlights the factors which promote recovery.
Emphasizes the clinical impact of ARF according to the areas where it is most likely to be seen.

Contents

I. The Pathophysiology of Acute Renal Failure
1. Morphologic basis of ARF Loraine C. Racusen
2. Vascular alterations in ARF: establishment and maintenance John Conger
3. Cytoskeletal alterations as a basis of cellular injury in ARF Bruce Molitoris
4. Heat shock proteins: role in prevention and recovery from ARF Norm Siegel
5. Growth factors and signal transduction in response to ARF Joe Bonventre
6. Inflammatory response and its consequences in ARF Robert Starr
7. DNA damage and repair in ARF Sudir Shah
8. Terminal pathways in cell death Wil Lieberthal
9. The role of iron and heme oxygenase in ARF Karl Nath

II. The Clinical Spectrum of Acute Renal Failure
1. Clinical and laboratory diagnosis Robert J. Anderson
2. Metabolic and electrolyte disturbances E.A. Burdman
3. Imaging techniques in ARF Richard Clark
4. Surgical and post-traumatic ARF Ori S. Better, Glen M. Chertow
5. ARF in pregnancy Susan H. Hou
6. Pigment nephropathy James P. Knochel, Karl Nath
7. ARF with cardiovascular disease J. Fort
8. ARF in liver disease Murray Epstein
9. ARF in rheumatologic disease P. Nachman, G. Eknoyan
10. ARF in burns E.M. Abdel-Rahman
11. Infectious disease Louis Yu, John Dillon
12. Malignancy David J. Salant, Kaml F. Badr
13. Transplantation Bryan Myers, Richard Zager
14. ARF associated with diagnostic and therapeutic agents Christiane M. Erley,
Marc DeBroe, Thomas DuBose, Jr., J.H. Turney
15. ARF with occupational and environmental settings Patricia Mueller, Geoff Dugin
16. ARF in natural disasters Norbert Lameire

III. Management of Acute Renal Failure
1. Patterns of recovery, residual injury, mortality rates William F. Finn
2. Nutritional support in patients with ARF Joel D. Kopple
3. Dialysis Claudio Ronco, Ravi H. Mehta, Raymond Hakim
4. Predictive factors and scoring F. Liano
5. Multiple organ system failure D. Kleinknecht