Reviews: All the aspects of this complex and rapidly moving field are covered in this excellent book. Clinical oncologists will find a series of balanced reviews of the current state-of-the-art of the diagnosis and treatment of cancer based on molecular technology, and since cancer touches almost every field of clinical practice, specialists in other disciplines will find a very lucid and readable account of what is happening in one of the genuine success stories of molecular medicine. From the foreword by Sir David Weatherall, FRS, Institute of Molecular Medicine, Oxford University, UK Principles of Molecular Oncology provides a bold new look at the evolution of our knowledge of cancer. Authors from many disciplines are bringing together the facets that provide a comprehensive view of the whole...The reader will enjoy the opportunity to pause and look at the whole field as it stands today. The book will be both informative and intellectually stimulating. From the foreword by E. Donnall Thomas, MD, Fred Hutchinson Cancer Research Center and Nobel Laureate in Medicine/Physiology, 1990 Practicing physicians and advanced medical students as well as biochemists, molecular biologiests, and geneticists involved in the identification of molecular markers, therapeutic targets, and the underlying basis of cancer will all benefit from the addition of Principles of molecular oncology to their bookshelves. The Lancet an excellent book devoted to exponentially evolving molecular oncology. The book under review covers the most important recent developments in the field of molecular oncology of human tumors in the way that can be understandable not only to clinical oncologists working in the field, but also to researchers of other fields as well. -Neoplasma Principles of Molecular Oncology' gives an up-to-date and comprehensive account of the revolution in molecular biology over the last few decades and its relevance to laboratory and clinical oncology. The book is clearly set out, with largely well conceived and descriptive illustrations. the scope and detail of scientific data provided means that even those well grounded in molecular biology will find much of novel value. The major strength of this book lies in the ultimate section on future therapies. In summary, this book is a detailed informative summary of current knowledge of molecular oncology, with relevance both to the general oncologist and those interested in basic molecular research. - Annals of Oncology is a useful text for both new and experienced investigators in cancer genetics. It provides a framework for learning how to evaluate the diagnostic, prognostic, and predictive value of the myriad new cancer-genetic alterations that will result from the HGP. -The American Society of Human Genetics presents a rather comprehensive state-of-the-art' of progress made during the past two decades in understanding the molecular bases of cancer. - Biochimie

Table of Contents

Part I. Molecular Markers. Selecting the Right Targets for Cancer Therapy, Miguel H. Bronchud and William P. Peters. Clinical Importance of Prognostic Factors: Moving from Scientifically Interesting to Clinically Useful, Daniel F. Hayes. Genetic Markers in Sporadic Tumors, S. Birindelli, A. Aiello, C. Lavarino, G. Sozzi, Silvana Pilotti, and Marco A. Pierotti. Cellular and Tissue Markers in Solid Tumors, Thomas Lindahl, Torbjön Norberg, Gunnar ström, Sigrid Sjögren, and C. Jonas Bergh. Circulating Tumor Markers, Alan Horwich and Gill Ross. Part II. Diseased Regulatory Pathways. Growth Factor-Signaling Pathways in Cancer, Daniel Kalderon. Estrogen Action and Breast Cancer, Hong Liu and V. Craig Jordan. Cyclin-Dependent Kinases and Their Regulators as Potential Targets for Anticancer Therapeutics, Leonardo Brizuela, Jeno Gyuris, and Muzammil Mansuri. Apoptosis Pathways: Clinical Relevance, Caroline Archer, Peter Trott, and Mitchell Dowsett. DNA Repair Pathways: Mechanisms and Defects in the Maintenance of Genome Stability, Murray O. Robinson. Angiogenesis Switch Pathways, Jaume Piulats and Francesc Mitjans. Invasion and Metastasis, Maria Rosa Bani and Rafaella Giavazzi. Molecular Pathways of Drug Resistance, Christos Tolis, Carlos G. Ferreira, Herbert M. Pinedo, and Giuseppe Giaccone. Part III. Future Directions. Antitumor Immunity as Therapy for Human Cancer, Angelo A. Cardoso. Emerging Technologies: Molecular Targets and the Drug Delivery Process, Mathew Moyle and Michael Palazzolo, Emerging Molecular Therapies for Cancer, Karol Sikora. Emerging Molecular Therapies: Small-Molecule Drugs, Paul Workman. Glossary. Index.