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The Liver "Biology And Pathobiology"

340.91
323.86
DESCRIPTION:
Bridging the gap between basic scientific advances and the understanding of liver disease the extensively revised new edition of the premier text in the field.

The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver""s growth, regeneration, metabolic functions, and more.

Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies.

Edited by globally-recognized experts in the field, this authoritative volume:
- Relates molecular physiology to understanding disease pathology and treatment - Links the science and pathology of the liver to practical clinical applications - Features 16 new "Horizons" chapters that explore new and emerging science and technology - Includes plentiful full-color illustrations and figures
The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.

CONTENTS:
Part One: Introduction
1 Organizational Principles of the Liver
2 Embryonic Development of the Liver
Part Two: The Cells
Section A: Cell Biology of the Liver
3 Cytoskeletal Motors: Structure and Function in Hepatocytes
4 Hepatocyte Surface Polarity
5 Primary Cilia
6 Endocytosis in Liver Function and Pathology
7 The Hepatocellular Secretory Pathway
8 Mitochondrial Function, Dynamics, and Quality Control
9 Nuclear Pore Complex
10 Protein Maturation and Processing at the Endoplasmic Reticulum
11 Protein Degradation and the Lysosomal System
12 Peroxisome Assembly, Degradation, and Disease
13 Organelle-Organelle Contacts: Origins and Functions
14 Gap and Tight Junctions in Liver: Structure, Function and Pathology
15 Ribosome Assembly and its Role in Cell Growth and Proliferation in the Liver
16 miRNAs and Hepatocellular Carcinoma
17 Hepatocyte Apoptosis: Mechanisms and relevance in liver diseases
Section B: The Hepatocyte
18 Copper Metabolism and the Liver
19 The Central Role of the Liver in Iron Storage and Regulation of Systemic Iron Homeostasis
20 Disorders of Bilirubin Metabolism
21 Hepatic Lipid Droplets in Liver Function and Disease
22 Lipoprotein Metabolism and Cholesterol Balance
Section C: Transporters, Bile Acids, and Cholestasis
23 Bile Acids Metabolism in Health and Disease: An update
24 TGR5 (GPBAR1) in the Liver
25 Bile Acids as Signaling Molecules
26 Hepatic Adenosine Triphosphate-Dependent (ABC) Transporters and Their Role in Physiology
27 Basolateral Plasma Membrane Organic Anion Transporters
28 Hepatic Nuclear Receptors
29 Molecular Cholestasis
30 Pathophysiologic Basis for Alternative Therapies for Cholestasis
31 Adaptive Regulation of Hepatocyte Transporters in Cholestasis
Section D: Non-Hepatocyte Cells
32 Cholangiocyte Biology and Pathobiology
33 Polycystic Liver Diseases: Genetics, Mechanisms, and Therapies
34 The Liver Sinusoidal Endothelial Cell: Basic Biology and Pathobiology
35 Fenestrations in the Liver Sinusoidal Endothelial Cell
36 Stellate Cells and Fibrosis
Part 3: Functions of the Liver
Section A: Metabolic Functions
37 Nonalcoholic Fatty Liver Disease and Insulin Resistance
38 AMPK: Central regulator of glucose and lipid metabolism and target of type 2 diabetes therapeutics
39 Insulin-mediated PI3K and AKT Signaling
40 Ca2+ Signaling in the Liver
41 Clinical Genomics of NAFLD
Section B: Liver Growth and Regeneration
42 Stem Cell-Fueled Maturational Lineages in Hepatic and Pancreatic Organogenesis
43 Developmental Morphogens and Adult Liver Repair
44 Liver Repopulation by Cell Transplantation and the Role of Stem Cells in Liver Biology
45 Liver Regeneration
46 -Catenin Signaling
47 Polyploidy in Liver Function, Mitochondrial Metabolism and Cancer
Part 4: Pathobiology of Liver Disease
48 Hepatic Encephalopathy
49 The Kidney in Liver Disease
50 Alpha-1 Antitrypsin Deficiency
51 Pathophysiology of Portal Hypertension
52 Nonalcoholic Fatty Liver Disease: Mechanisms and treatment
53 Alcoholic Liver Disease
54 Drug-induced Liver Injury
55 Oxidative Stress and Inflammation in the Liver
56 The Role of Bile Acid-mediated Inflammation in Cholestatic Liver Injury
57 Toll-like Receptors in Liver Disease
Part 5: Liver Cancer
58 Experimental Models of Liver Cancer: Genomic assessment of experimental models
59 Epidemiology of Liver Cancer
60 Mutations and Genomic Alterations in Liver Cancer
61 Treatment of Liver Cancer
Part 6: Hepatitis
62 Molecular Biology of Hepatitis Viruses
63 Immune Mechanisms of Viral Clearance and Disease Pathogenesis during Viral Hepatitis
64 Clinical Implications of the Molecular Biology of Hepatitis B Virus
65 Viral Escape Mechanisms in Hepatitis C and the Clinical Consequences of Persistent Infection
66 Tracking Hepatitis C Virus Interactions with the Hepatic Lipid Metabolism: A hitchhiker s guide to solve remaining translational research challenges in hepatitis C
67 Nucleoside Antiviral Agents for HCV: What""s left to do?
68 Hepatitis E Virus: An emerging zoonotic virus causing acute and chronic liver disease
69 Biological Principles and Clinical Issues Underlying Liver Transplantation for Viral-Induced End-stage Liver Disease in the Era of Highly Effective Direct-Acting Antiviral Agents
70 Time for the Elimination of Hepatitis C Virus as a Global Health Threat
Part 7: Horizons
H1 Genome Editing by Targeted Nucleases and the CRISPR/Cas Revolution
H2 Imaging Cellular Proteins and Structures: Smaller, Brighter, and Faster
H3 Liver-directed Gene Therapy
H4 Telomeres and Telomerase in Liver Generation and Cirrhosis
H5 Toxins and Biliary Atresia
H6 The Dual Role of ABC Transporters in Drug Metabolism and Resistance to Chemotherapy
H7 Stem-cell-derived Liver Cells: From model system to therapy
H8 Extracellular Vesicles and Exosomes: Biology and pathobiology
H9 Integrated Technologies for Liver Tissue Engineering
H10 Stem Cells, IPS Cells, Reprogramming: Therapy promise
H11 Chromatin Regulation and Transcription Factor Cooperation in Liver Cells
H12 Drug Interactions in the Liver
H13 Metabolic Regulation of Hepatic Growth
H14 The Gut Microbiome and Liver Disease
H15 Lineage Tracing: Efficient tools to determine the fate of hepatic cells in health and disease
H16 The Hepatocyte as a Household for Plasmodium Parasites
ISBN
978-1-119-43682-9
EAN
9781119436829
Editor
John Wiley & Sons, Ltd.
Stock
SI
Idioma
Inglés
Nivel
Profesional
Formato
Encuadernado
Tapa Dura
Páginas
1144
Largo
290
Ancho
220
Peso
-
Edición
Fecha de edición
27-01-2020
Año de edición
2020
Nº de ediciones
6
Colección
-
Nº de colección
-