In this book we provide insights into liver cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials.

Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical inflammation-induced cancer.

Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.

Table of contents (9 chapters)
Vaccine Approaches in Hepatocellular Carcinoma

Tagliamonte, Maria (et al.)

Pages 1-17
Natural Killer Cells in Hepatocellular Carcinoma: Anti-Tumor Effect and Therapeutic Potential

Cariani, Elisabetta (et al.)

Pages 19-38
Antigen-Specific T Cell Responses in Hepatocellular Carcinoma

Mizukoshi, Eishiro (et al.)

Pages 39-50
Immune Checkpoint Inhibitors for the Treatment of Hepatocellular Carcinoma

Iñarrairaegui, Mercedes (et al.)

Pages 51-68
Cytokine-Induced Killer Cells for the Adjuvant Treatment of Patients with HCC

Lee, Jeong-Hoon (et al.)

Pages 69-84
Anti-VEGFR Therapy as a Partner for Immune-Based Therapy Approaches in HCC

Shigeta, Kohei (et al.)

Pages 85-101
Glypican-3 as a Target for Immune Based Therapy in Hepatocellular Carcinoma

Zhang, Yi-Fan (et al.)

Pages 103-119
Immune Suppressor Mechanisms in HCC

Greten, Tim F. (et al.)

Pages 121-135
Impact of Cytokines in Hepatocellular Carcinoma Initiation and Progression

Ait-Ahmed, Yeni (et al.)

Pages 137-161