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In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals.
Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field.
Table of contents (13 chapters) The Impact of the Intestinal Microbiota in Therapeutic Responses Against Cancer
Mélodie Bonvalet, et al.
Pages CD8+ T Cells in Immunotherapy, Radiotherapy, and Chemotherapy
Weimin Wang, et al.
Pages Innate Immune Receptors in the Regulation of Tumor Immunity
Sho Hangai, et al.
Pages Tumor-Targeted Antibodies
Aurélien Marabelle MD, PhD
Pages Peptide-Based Therapeutic Cancer Vaccines
Cornelis J. M. Melief
Pages Regulatory T Cells: Their Role, Mechanism of Action, and Impact on Cancer
Anthony R. Cillo, Dario A. A. Vignali
Pages Current Status of Immuno-Oncology in Hematologic Cancers
Bertrand Routy, David Ghez
Pages Strategies to Reduce Intratumoral Regulatory T Cells
C. Maherzi, et al.
Pages Immunotherapy of Gliomas
Pages IDO/TDO Inhibition in Cancer
George C. Prendergast, et al.
Pages The Secrets of T Cell Polarization
Thaiz Rivera Vargas, Lionel Apetoh
Pages Side Effects of Cancer Immunotherapy with Checkpoint Inhibitors
Lucia Festino, Paolo A. Ascierto
Pages Cancer Immunosurveillance by Natural Killer Cells and Other Innate Lymphoid Cells