Discusses the development of insulin-producing cells, the biggest research focus of stem cell biologists seeking a cure for diabetes
Explores key aspects of islet biology ranging from embryonic development and stem cell differentiation to clinical studies in islet transplantation
Provides worldwide expertise and an international perspective on the different approaches to pancreatic islet research

This comprehensive volume discusses in vitro laboratory development of insulin-producing cells. It encompasses multiple aspects of islet biology from embryonic development and stem cell differentiation to clinical studies in islet transplantation, regulation of islet beta-cell regeneration, pancreatic progenitors, mathematical modelling of islet development, epigenetic regulation, and much more. The chapter authors represent leading laboratories from around the world who contribute their international perspectives and global expertise. Collectively, they provide the reader with a concise yet detailed knowledge of processes and current developments in islet regenerative biology.

Pancreatic Islet Biology, part of the Stem Cell Biology and Regenerative Medicine series, is essential reading for researchers and clinicians in stem cells or endocrinology, especially those focusing on diabetes

Table of contents (12 chapters)
The Pathobiology of Diabetes Mellitus
Jenkins, Alicia J. (et al.)
Pages 1-48
Comparative Analysis of Islet Development
Poudel, Ananta (et al.)
Pages 49-63
Mathematical Modeling of Islet Generation, Degeneration and Regeneration
Jo, Junghyo (et al.)
Pages 65-81
Epigenetic Regulation of Islet Development and Regeneration
Khare, Satyajeet (et al.)
Pages 83-109
Pancreatic Regeneration After Partial Pancreatectomy in Rodents
Li, Wan-Chun (et al.)
Pages 111-123
Regulators of Beta-Cell Death and Regeneration
Takasawa, Shin (et al.)
Pages 125-158
MicroRNAs: A Link Between Type 1 Diabetes and the Environment?
Akil, Ammira Al-Shabeeb (et al.)
Pages 159-192
Transdifferentiation of Extra-Pancreatic Tissues for Cell Replacement Therapy for Diabetes
Meivar-Levy, Irit (et al.)
Pages 193-215
Generation of Human Islet Progenitor Cells via Epithelial-to-Mesenchymal Transition
Wong, Wilson (et al.)
Pages 217-240
Viral-Mediated Gene Therapy for the Generation of Artificial Insulin-Producing Cells as a Therapeutic Treatment for Type 1 Diabetes Mellitus
Gerace, Dario (et al.)
Pages 241-255
Regenerative Medicine: Clinical Islet Transplantation
Thomas, Helen E. (et al.)
Pages 257-283
Beta Cell Therapies for Type 1 Diabetes
Hawthorne, Wayne John
Pages 285-