As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine.


The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states.

Key Features
Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease
Explains the practice of molecular medicine and the translational aspects of molecular pathology
Teaches from the perspective of integrative systems biology
Includes an ancillary website that hosts a complete set of PowerPoint slides, including images from the book, additional images and self-assessment questions

Table of Contents
1. Molecular Mechanisms of Cell Death
2. Acute and Chronic Inflammation Induces Disease Pathogenesis
3. Infection and Host Response
4. Neoplasia
5. Basic Concepts in Human Molecular Genetics
6. The Human Genome: Implications for the Understanding of Human Disease
7. The Human Transcriptome: Implications for the Understanding of Human Disease
8. The Human Epigenome: Implications for the Understanding of Human Disease
9. Clinical Proteomics and Molecular Pathology
10. Integrative Systems Biology: Implications for the Understanding of Human Disease
11. Pathology: The Clinical Description of Human Disease
12. Understanding Molecular Pathogenesis: Implications for Improved Treatment of Human Disease
13. Integration of Molecular and Cellular Pathogenesis: A Bioinformatics Approach
14. Molecular Basis of Cardiovascular Disease
15. Molecular Basis of Hemostatic and Thrombotic Diseases
16. Molecular Basis of Lymphoid and Myeloid Diseases
17. Molecular Basis of Diseases of Immunity
18. Molecular Basis of Pulmonary Disease
19. Molecular Basis of Diseases of the Gastrointestinal Tract
20. Molecular basis of Liver Disease
21. Molecular basis of diseases of the exocrine pancreas
22. Molecular Basis of Diseases of the Endocrine System
23. Molecular Basis of Gynecologic Diseases
24. Molecular Basis of Kidney Disease
25. Molecular Pathogenesis of Prostate Cancer
26. Molecular Biology of Breast Cancer
27. Molecular Basis of Skin Disease
28. Molecular Basis of Bone diseases
29. Molecular Basis of Diseases of the Nervous System
30. Molecular Diagnosis of Human Disease
31. Molecular Assessment of Human Disease in the Clinical Laboratory
32. Pharmacogenomics and Personalzed Medicine in the Treatment of Human Disease