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Alpha-1 Antitrypsin "Role in Health and Disease"

  • EDITOR Springer Verlag Gmbh&Co. Kg
  • NIVEL Profesional
  • STOCKNO
  • IDIOMAInglés
Códigos
  • ISBN 978-3-319-23448-9
  • EAN 9783319234489
Colección
  • Colección -
  • Número -
Características
  • Encuadernado Tapa Dura
  • Páginas 173
  • Largo -
  • Ancho -
  • Peso -
Edición
  • Fecha 04-01-2016
  • Número 1
  • Año 2016
Reseña
This book offers a comprehensive overview of alpha-1 antitrypsin deficiency, an inherited condition that leads to lung disease in adults and liver disease in adults and children and is associated with chronic obstructive lung disease in adults. While it is a rare condition, the mechanisms underlying the clinical manifestations of this deficiency have been largely clarified. Treatment, however, is available only for the lung disease that arises from the condition, thus necessitating continued research into new and alternative therapeutic solutions. The book discusses the biology of alpha-1 antitrypsin, protein misfolding and polymerization, and diagnosis and treatment of alpha-1 antitrypsin deficiency and its associated diseases. It concludes with a discussion of rare disorders linked to alpha-1 antitrypsin deficiency and the role of healthcare organizations in the treatment of these diseases. Written for pulmonary clinicians and scientists, Alpha-1 Antitrypsin: Role in Health and Disease is a valuable resource that sheds light on this rare disease.

Alpha-1-Antitrypsin and the Serpins
Carrell, Robin
Pages 1-15
Alpha-1 Antitrypsin: The Protein
Lussier, Bethany (et al.)
Pages 17-30
Misfolding and Polymerisation of Alpha
Gooptu, Bibek (et al.)
Pages 31-52
Managing the Adaptive Proteostatic Landscape: Restoring Resilience in Alpha-1 Antitrypsin Deficiency
Wang, Chao (et al.)
Pages 53-83
United States Targeted Detection Program for Alpha-1 Antitrypsin Deficiency
Tonelli, Adriano R. (et al.)
Pages 85-98
Lung Disease of Alpha-1 Antitrypsin Deficiency
Sandhaus, Robert A.
Pages 99-110
Liver Disease in a1-Antitrypsin Deficiency
Mukherjee, Amitava (et al.)
Pages 111-140
Alpha-1 Antitrypsin as a Therapeutic Agent for Conditions not Associated with Alpha-1 Antitrypsin Deficiency
Wanner, Adam
Pages 141-155
The Alpha-1 Constellation of Voluntary Health Organizations as a Paradigm for Confronting Rare Diseases
Walsh, John W.

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