Features

Details the mechanisms of lipid oxidation, both enzymatic and non-enzymatic
Illustrates the relationship between lipid oxidation and antioxidant defenses
Describes the modulation of cell signaling by lipid oxidation products
Summarizes the various roles of oxidized lipids in specific diseases including cardiovascular, neurodegenerative, and metabolic disorders, as well as in cancer
Examines drug targeting and the therapeutic potential of oxidized lipids
Summary

Oxidative modification of lipids and phospholipids including radical damage, halogenation, and nitration result in significant changes to the chemical properties of the molecules, which in turn have a major effect on their biochemical functions. Lipid oxidation has long been regarded as a deleterious process responsible for lipid rancidity, loss of function, and generation of toxic products. However in recent years, research has also focused on the non-detrimental physiological and pathological effects of these chemical reactions. Lipid Oxidation in Health and Disease provides an up-to-date review of the role of oxidized lipid products in physiological and pathophysiological processes.

Covering the diverse topics that contribute to research in this important field, this book explores:

The mechanisms of lipid oxidation, both enzymatic and non-enzymatic
Antioxidant defenses and lipid oxidation
Lipid oxidation products and cell signaling
The roles of oxidized lipids in specific diseases including cardiovascular, neurodegenerative, and metabolic disorders, as well as in cancer
Drug targeting and the therapeutic potential of oxidized lipids
Accurate measurement of the formation of lipid oxidation products and investigation of their biological effects and roles in disease are critical to biomedical science and new targeted therapeutics. Written by acknowledged experts in the field, this book provides a broad survey of both established knowledge and recent findings on the action of oxidized lipid products on cell signaling and gene expression in health and disease.

Table of Contents

An Introduction to Redox Balance and Lipid Oxidation
Corinne M. Spickett, Maria Fedorova, Ralf Hoffmann, and Henry Jay Forman
CHEMISTRY AND BIOCHEMISTRY OF LIPID OXIDATION
Nonenzymatic Mechanisms of Lipid Oxidation
Claus Schneider and Sean S. Davies
Enzymatic Oxidation of Polyunsaturated Fatty Acids
Sharon A. Murphy, Naser M. I. Al-Aaswad, and Anna Nicolaou
Halogenated Lipids: Products of Peroxidase-Derived Reactive Halogenating Species Targeting Conventional Lipids
David A. Ford
Formation of Nitrated Lipids and Their Biological Relevance
Andrés Trostchansky and Homero Rubbo
Protein Lipoxidation
Koji Uchida
Analysis of Lipid Peroxidation Products in Health and Disease
Michael J. Thomas
SITES OF BIOLOGICAL ACTIONS OF OXIDIZED LIPIDS
Oxidized Lipids as Damage-Associated Molecular Patterns in Inflammatory Responses
Maria Fedorova and Ralf Hoffmann
Formation and Beneficial Roles of Polyunsaturated Lipid Mediators: Lipoxins, Resolvins, Protectins, and Maresins
Nicos A. Petasis
Pro- and Anti-Inflammatory Action of Oxidized Phospholipids
Maria Philippova, Olga Oskolkova, and Valery N. Bochkov
Modulation of Toll-Like Receptor Signaling by Oxidized Phospholipids
Vlad Serbulea and Norbert Leitinger
Dietary Oxidized Lipids as Regulators of Intracellular Signaling Pathways: PPAR and NF-KB
Robert Ringseis, Denise K. Gessner, and Klaus Eder
Oxidized and Nitrated Lipid Interactions with the
Keap1-Nrf2 Pathway
Emilia Kansanen and Anna-Liisa Levonen
OXIDIZED LIPIDS IN PATHOLOGY AND DISEASE
Role of Oxidized Phospholipids in Cardiovascular Disease
Gregor Leibundgut, Adam Taleb, and Sotirios Tsimikas
Cholesterol Oxidation Products in the Initiation, Progression, and Fate of Atherosclerotic Lesions
Giuseppe Poli, Simona Gargiulo, Paola Gamba, Barbara Sottero, Fiorella Biasi, and Gabriella Leonarduzzi
Lipid Peroxidation and Age-Related Neurodegenerative
Disorders
Tanea T. Reed, Zachariah P. Sellers, and D. Allan Butterfield
Association of Oxidative Stress and Lipids with Risk Factors of Metabolic Syndrome
Sampath Parthasarathy, Chandrakala Aluganti Narasimhulu, Irene Fernandez Ruiz, Kathryn Young, Vivek Krishna Pulakazhi Venu, Xueting Jiang, and Aladdin Riad
Oxidized Lipid Products and Carcinogenesis
Françoise Guéraud