Provides an overview of the disposition of nanoproducts within the body
Focuses on respiratory, olfactory, buccal, gastrointestinal tract, skin, follicular unit, ocular, and intravenous routes of nanoproduct administration
Introduces potentially beneficial applications and exciting topics regarding nanoproducts to a variety of professional and general readers
Addresses the scope of practical nanoparticle applications in academic research as well as industrial investigation
Offers an interdisciplinary, big-picture view of the current and future state of nanotechnology
Summary

Nanomedicines and Nanoproducts: Applications, Disposition, and Toxicology in the Human Body provides a detailed overview of the disposition of nanoproducts within the body, with a special focus on the respiratory and olfactory routes of nanoproduct administration, buccal exposure and the ingestion of nanoproducts, the integumentary system (formed by the skin, hair, nails, and associated glands), the ocular route, the systemic route, and toxicology as it relates to the nanoscale world.

Offering an interdisciplinary, big-picture view of the current and future state of nanotechnology, this book:

Identifies key points for the entry of nanoproducts, nanomedicines, and other nanoscale structures into the body
Reviews the bodily administration and subsequent disposition of nanoproducts via various exposure routes
Describes the intravenous route of administration for the therapeutic management of ocular disease
Discusses practical nanoproduct and nanomedicine applications, disposition, and toxicology
Summarizes various toxicological principles and the testing of nanoproducts
Nanomedicines and Nanoproducts: Applications, Disposition, and Toxicology in the Human Body addresses the scope of practical nanoparticle applications in academic research as well as industrial investigation, where "practical" is defined as advantageous in all aspects of nanoproduct disposition, efficacy, and toxicology. The book's goal is to introduce potentially beneficial applications and exciting topics regarding nanoproducts to a variety of professional and general readers.

Table of Contents

Nanoscale World
Scope of Nanoproducts
Disposition of Nanoproducts and Nanoparticles
Polydispersity of Nanoparticles and Penetration Barriers in the Body
Physicochemical Properties of Nanoparticles
History of Nanotechnology and Nanomedicine
Overview of the Nanoscale World
References
Overview of Nanoproduct Disposition
Pathways for Nanoproduct Absorption, Distribution, and Excretion
Liberation, Absorption, Distribution, Metabolism, and Excretion
Liberation
Bioavailability
Volume of Distribution
Clearance
References
Respiratory and Olfactory Routes
Anatomy and Physiology
Practical Application of Biodegradable Nanomedicines
Practical Application of Nonbiodegradable Nanomedicines
Inhalation of Nanoproducts
Transport and Liberation of Inhaled Products
Absorption via the Alveoli
Distribution and Translocation
Disposition of Nanomedicines from the Nasal Cavity to Systemic Tissues
Clearance of Nanoparticles
Nanoscale World according to the Respiratory and Olfactory Routes
References
Buccal Route and Ingestion
Anatomy and Physiology
Factors Affecting Nanoparticle Disposition
Practical Applications of Nanoproducts
Risks and Benefits of Nanoscale Food Packaging Products and Nanofoods
Bioavailability of Nanomedicines and Nanofoods
Cellular Endocytosis of Nanoparticles
Disposition of Nanoparticles Following Oral Administration
Nanoscale World via the Buccal Route and Ingestion
References
The Integumentary System and the Ocular Route
Anatomy and Physiology
Practical Applications in Skin Care
Practical Applications in Ocular Medical Care
Exposure to Sunlight and Nanoparticle Toxicity
Factors Affecting Permeability and Disposition in the Integumentary System
Nanoscale World via the Integumentary System and the Ocular Route
References
Systemic Route
Anatomy and Physiology
Pathway from Systemic Exposure to Local Delivery
Endocytosis of Nanoparticles
Nuclear Transport
Cell Transition/Translocation
Practical Application of Nanomedicines
Engineering of Nanomedicines
Engineering of Nanoproducts Targeting Disease
Nanoscale World via the Systemic Route
References
Toxicology in the Nanoscale World
Characteristics of Exposure
Spectrum of Undesired Effects
Tolerance
Dose-Response Relationships
Descriptive Animal Toxicity Tests
Nanoproduct Compatibility with the Immune System
References