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Highlights emerging new principles of immune suppression that drive cancer and offers radically new ideas about how therapy can be improved by attacking these principles.

Synthesizes concepts that are useful to both cancer immunologists and pharmacologists
Summarizes the latest insights into how immune escape defines an essential trait of cancer
Includes numerous illustrations to clarify advanced concepts

Description

There has been major growth in understanding immune suppression mechanisms and their relationships to cancer progression and therapy. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumoral immune suppression. The second edition of Cancer Immunotherapy highlights emerging principles of immune suppression that drive cancer and offers new ideas about how therapy can be improved by attacking these principles.

Beginning by reviewing current understanding of cancer immunobiology and therapeutics, the book moves into a deep examination of cancer immunosuppression and how it might be defeated. These chapters cover topics such as dendritic cells and co-inhibitory molecules, regulatory T-cells, tumor-associated macrophages, myeloid-derived suppressor cells, and factors in immune escape.

Authored by two internationally recognized leaders in cancer biology and immunology, this book provides basic, translational, and clinical cancer researchers an indispensable overview of immune escape as a critical trait in cancer, and how applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease.

Part I: Principles of Cancer Immunobiology
Introduction
Cancer Immunoediting: From Immune Surveillance to Immune Escape
Immunosurveillance: Innate and Adaptive Anti-Tumor Immunity
Cytokine Regulation of Immune Tolerance to Tumors
Immunological Sculpting: Natural Killer Cell Receptors and Ligands
Immune Escape: Immunosuppressive Networks
Part II: Cancer Therapeutics
Cytotoxic Chemotherapy in Clinical Treatment of Cancer
Targeted Therapeutics in Cancer Treatment
Concepts in Pharmacology and Toxicology
Cancer Immunotherapy: Challenges and Opportunities
Cancer Vaccines
Part III: Targets and Tactics to Improve Cancer Immunotherapy By Defeating Immune Suppression
Immunotherapy and Cancer Therapeutics: Why Partner?
Immune Stimulatory Features of Classical Chemotherapy
Dendritic Cells and Co-Inhibitory Molecules
Regulatory T Cells in Tumor Immunity: Role of Toll-like Receptors
Tumor-associated Macrophages in Cancer Growth and Progression
Tumor-associated Myeloid-derived Suppressor Cells
Programmed Death Ligand-1 and Galectin-1: Pieces in the Puzzle of Tumor Immune Escape
IDO in Immune Escape: Regulation and Therapeutic Inhibition
Arginase, Nitric Oxide Synthase, and Novel Inhibitors of L-arginine Metabolism in Immune Modulation
Summary: Future Questions
ISBN
978-0-12-394296-8
EAN
9780123942968
Editor
Academic Press Ltd.
Stock
NO
Idioma
Inglés
Nivel
Profesional
Formato
Encuadernado
Tapa Dura
Páginas
688
Largo
280
Ancho
220
Peso
-
Edición
Fecha de edición
03-09-2013
Año de edición
2013
Nº de ediciones
2
Colección
-
Nº de colección
-