Fetal treatment, particularly complex fetal therapy, is an emergent and expanding field. This comprehensive text focuses on areas of fetal disease and pathophysiology that can be treated in utero and the benefits and problems with such therapy. Both medical (non-invasive) and surgical procedures are discussed, drawing on the expertise of an internationally renowned author team. Each chapter includes a comprehensive overview of the basic science underlying fetal pathology, as well as discussing the highest level of technical performance of fetal interventions. Contributions from fetal therapy 'centers-of-excellence' around the world collectively emphasize the need for an evidence-based approach to the field. This volume is useful both as a quick reference guide to the latest fetal therapy options and as an in-depth study book for maternal-fetal medicine and neonatology specialists at any stage of their career who are seeking to acquire essential background knowledge. Indispensable on any bookshelf in fetal medicine units.


Table of Contents
Preface
Foreword
Part I. General Principles: 1. The rationale for fetal therapy
2. Insights into pathogenesis of adult cardiovascular disease from fetal animal studies
3. Human embryology: molecular mechanisms of embryonic disease
4. Ethics of fetal therapy
5. Fetal therapy choices: about risks, emotions, and the doctor's role in the decision making process
Part II. Fetal Disease: Pathogenesis and Principles: 6. Red cell alloimmunization: immunobiology, clinical disease, and management
7. Fetal and neonatal alloimmune thrombocytopenia
8.1. Fetal dysrhythmias: the effects of antiarrhythmic therapy on the immature heart
8.2. Fetal dysrhythmias: clinical management
9.1. Structural heart disease: embryology
9.2. Structural heart disease: genetic influences
9.3. Structural heart disease: fetal cardiac interventions
10.1. Manipulation of amniotic fluid volume: homeostasis of fluid volumes in the amniotic cavity
10.2. Manipulation of amniotic fluid volume: oligohydramnios and polyhydramnios
11.1. Twin-to-twin transfusion syndrome: scientific basis
11.2. Twin-to-twin transfusion syndrome: placental circulation
11.3. Twin-to-twin transfusion syndrome: cardiovascular manifestations
11.4. Twin-to-twin transfusion syndrome: treatment by fetoscopic laser ablation
11.5. Twin-to-twin transfusion syndrome: management of stage I disease
12.1. Twin reverse arterial perfusion (TRAP) sequence: pathophysiology
12.2. Twin reverse arterial perfusion (TRAP) sequence: in-utero treatment
13.1. Fetal infections: fetal immune responses to congenital infections
13.2. Fetal infections: clinical management
14.1. Fetal urinary tract obstruction: pathophysiology
14.2. Fetal urinary tract obstruction: prenatal assessment and prognosis
14.3. Fetal urinary tract obstruction: fetal cystoscopy
14.4. Fetal urinary tract obstruction: in-utero intervention
15.1. Fetal lung growth, development and lung fluid: physiology and pathophysiology
15.2. Fetal lung growth, development, and lung fluid: clinical management of pleural effusion and pulmonary pathology
16.1. Neural tube defects: pathophysiology and prevention
16.2. Neural tube defects: clinical management
17.1. Fetal tumors: pathophysiology
17.2. Fetal tumors: clinical management
18.1. Intrauterine growth restriction: placental basis and implications for clinical practice
18.2. Intrauterine growth restriction: differential diagnosis and management
19.1. Congenital diaphragmatic hernia: pathophysiology
19.2. Congenital diaphragmatic hernia: clinical antenatal management
20.1. Fetal stem cell transplantation: stem cell biology basics
20.2. Fetal stem cell transplantation: clinical potential
20.3. Fetal stem cell transplantation: fetal tissue engineering
21. Gene therapy: physiological principles and clinical potential
22. The future: fetal therapies and translation studies: global alignment, coordination and collaboration in perinatal research: The Global Obstetrics Network (GONet) initiative
Index