Molecular Diagnostics in Dermatology and Dermatopathology presents the basics of molecular biology and molecular diagnostic methods most commonly used in the clinical laboratory, with an emphasis on the concepts and testing most relevant to dermatological diseases. Topics include the integration of newer diagnostic and prognostic techniques with traditional' histologic approaches, and discussions of regulatory, ethical, legal, economic issues and newer' technologies. This important diagnostic tool outlines the clinically relevant uses (i.e.; diagnostic, staging and/or prognostic) applications of these techniques in the field of dermatology. Molecular studies that investigate the pathogenesis of skin diseases will be excluded, unless they also have a direct diagnostic utility. The book will be of interest to practicing pathologists, dermatology and pathology residents, dermatologists, and dermatopathologists.

1 Introduction to Molecular Diagnostic Testing in Dermatology
and Dermatopathology..................................................................................................... 1
Michael J. Murphy
2 Principles of Molecular Biology....................................................................................... 13
Jian Zhuge and Wenyong Zhang
3 Technologies in the Molecular Diagnostics Laboratory................................................ 27
Zendee Elaba, Michael J. Murphy, and Laila Mnayer
4 Cytogenetics of Primary Skin Tumors............................................................................ 57
Melanie A. Carless and Lyn R. Griffiths
5 Melanocytic Neoplasms I: Molecular Diagnosis............................................................ 73
Pedram Gerami, Bryan Gammon, and Michael J. Murphy
6 Melanocytic Neoplasms II: Molecular Staging.............................................................. 105
Michael J. Murphy and J. Andrew Carlson
7 Non-Melanoma Skin Cancers and Hereditary Cancer Syndromes............................. 131
Zhenyu Ji, Victor Neel, and Hensin Tsao
8 Cutaneous Sarcomas and Soft Tissue Proliferations..................................................... 145
Omar Jassim and John D. Pfeifer
9 Molecular Determination of Tissue Margins, Clonal Origin,
and Histogenesis of Skin Cancers.................................................................................... 191
Michael J. Murphy
10 Mycosis Fungoides and Related Lesions......................................................................... 203
Michael J. Murphy
11 Cutaneous Non-MF T-Cell and NK-Cell Lymphoproliferative Disorders.................. 233
Shih-Sung Chuang
12 Cutaneous B-Cell Lymphomas........................................................................................ 247
Antonio Subtil
x Contents
13 Leukemia Cutis................................................................................................................. 263
Michael J. Murphy
14 Inflammatory Disorders of the Skin................................................................................ 283
Michael J. Murphy, Amanda Phelps, and Markus Braun-Falco
15 Infectious Diseases of the Skin I: Dermatophytosis/Onychomycosis........................... 311
Pranab K. Mukherjee, Nancy Isham, and Mahmoud A. Ghannoum
16 Infectious Diseases of the Skin II: Non-Dermatophytic Infections.............................. 339
Michael J. Murphy and Avery LaChance
17 Wound Healing Disorders: Chronic Wounds and Keloids............................................ 359
Michael J. Murphy
18 Alopecias........................................................................................................................... 369
Diane M. Hoss and Michael J. Murphy
19 Genodermatoses: Inherited Diseases of the Skin........................................................... 379
Frances J.D. Smith and W.H. Irwin McLean
20 Molecular Aspects of Skin Aging..................................................................................... 411
Michael J. Murphy
21 Pharmacogenetics and Pharmacogenomics I: Linking Diagnostic
Classification to Therapeutic Decisions.......................................................................... 419
Michael J. Murphy, Carlo Pincelli, Diane M. Hoss, and Riccardo G. Borroni
22 Pharmacogenetics and Pharmacogenomics II: Genetic Determinants
of Drug Responses and Adverse Drug Reactions........................................................... 443
Stephane Dalle, Sandra Knowles, and Neil H. Shear
23 Regulatory, Legal, Coding, Billing, Reimbursement,
and Ethical Considerations for Molecular Diagnostic Testing
in Dermatology and Dermatopathology.......................................................................... 453
Deborah Ann Payne
Additional Resources................................................................................................................ 465
Index.......................................................................................................................................... 467