Overview on the Lower Urinary Tract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Christopher Chapple
Animal Models in Overactive Bladder Research . . . . . . . . . . . . . . . . . . . . . . . . . . . 15
Brian A. Parsons and Marcus J. Drake
Animal Models of Stress Urinary Incontinence . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45
Hai-Hong Jiang and Margot S. Damaser
Animal Models for Benign Prostatic Hyperplasia . . . . . . . . . . . . . . . . . . . . . . . . . . 69
J. Paul Hieble
Use of Functional Imaging to Monitor Central Control of Voiding
in Humans . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81
Derek J. Griffiths
Neuroanatomy of the Lower Urinary Tract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99
Jonathan M. Beckel and Gert Holstege
Anatomy and Histology of the Lower Urinary Tract . . . . . . . . . . . . . . . . . . . . . 117
Wisuit Pradidarcheep, Christian Wallner, Noshir F. Dabhoiwala,
and Wouter H. Lamers
Neurophysiology of the Lower Urinary Tract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 149
Jonathan M. Beckel and Gert Holstege
Afferent Mechanism in the Urinary Tract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 171
Anthony J. Kanai
Urothelial Signaling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 207
Lori A. Birder
ix
Interstitial Cells of Cajal in the Urinary Tract . . . . . . . . . . . . . . . . . . . . . . . . . . . . 233
Karen D. McCloskey
Potential Applications of Gene Therapy/Transfer to the Treatment
of Lower Urinary Tract Diseases/Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 255
George J. Christ
Specific Pharmacokinetic Aspects of the Urinary Tract . . . . . . . . . . . . . . . . . . 267
Cees Korstanje and Walter Krauwinkel
a1-Adrenoceptors in the Urinary Tract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 283
Shizuo Yamada and Yoshihiko Ito
b-Adrenergic Receptor Subtypes in the Urinary Tract . . . . . . . . . . . . . . . . . . . 307
Martin C. Michel
Muscarinic Acetylcholine Receptors in the Urinary Tract . . . . . . . . . . . . . . . 319
K.-E. Andersson
Modulation of Urinary Bladder Innervation: TRPV1
and Botulinum Toxin A . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 345
Ana Charrua, Anto nio Avelino, and Francisco Cruz
Ion Channel Modulators and Urinary Tract Function . . . . . . . . . . . . . . . . . . . . 375
A.F. Brading and K.L. Brain
Neuropeptides in Lower Urinary Tract Function . . . . . . . . . . . . . . . . . . . . . . . . . . . 395
Lauren Arms and Margaret A. Vizzard
Cannabinoids: Potential Targets for Bladder Dysfunction . . . . . . . . . . . . . . . 425
Michael R. Ruggieri, Sr
Vasopressin Receptors in Voiding Dysfunction . . . . . . . . . . . . . . . . . . . . . . . . . . . . 453
Sailaja Pisipati and Hashim Hashim
ATP and P2X Purinoceptors in Urinary Tract Disorders . . . . . . . . . . . . . . . . 485
Anthony P.D.W. Ford and Debra A. Cockayne
Cyclic Nucleotide Metabolism Including Nitric Oxide and
Phosphodiesterase-Related Targets in the Lower Urinary Tract . . . . . . . . 527
Stefan U ckert and Markus A. Kuczyk
Rho-Kinase, a Common Final Path of Various Contractile
Bladder and Ureter Stimuli . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 543
Xinhua Zhang and Michael E DiSanto
Index