Contents

Introduction. Part I: Principles of Psychopharmacology. Neurotransmitters, receptors, signal transduction, and second messengers in psychiatric disorders. Basic principles of molecular biology and genomics. Genetics and genomics. Chemical neuroanatomy of the primate brain. Electrophysiology. Animal models. Psychoneuroendocrinology. Principles of pharmacokinetics and pharmacodynamics. Brain immune system interactions: relevance to the pathophysiology and treatment of neuropsychiatric disorders. Brain imaging in psychopharmacology. Statistics, placebo response, and clinical trial design in psychopharmacology. Part II: Classes of Psychiatric Treatments: Animal and Human Pharmacology. Antidepressants and Anxiolytics. Tricyclic and tetracyclic drugs. Fluoxetine. Sertraline. Paroxetine. Fluvoxamine. Citalopram and s-citalopram. Monoamine oxidase inhibitors. Trazodone and nefazodone. Bupropion. Mirtazapine. Venlafaxine and desvenlafaxine. Duloxetine and milnacipran. Benzodiazepines. Buspirone and gepirone. Putative new-generation antidepressants. Antipsychotics. Classic antipsychotic medications. Clozapine. Olanzapine. Quetiapine. Aripiprazole. Risperidone and paliperidone. Ziprasidone. Drugs to treat extrapyramidal side effects. Drugs for Treatment of Bipolar Disorder. Lithium. Valproate. Carbamazepine and oxcarbazepine. Gabapentin and pregabablin. Lamotrigine. Topiramate. Other Agents. Cognitive enhancers. Sedative-hypnotics. Psychostimulants and wakefulness-promoting agents. Electroconvulsive therapy. Part III: Clinical Psychobiology and Psychiatric Syndromes. Neurobiology of mood disorders. Neurobiology of schizophrenia. Neurobiology of anxiety disorders. Neurobiology of Alzheimer's disease. Neurobiology of substance abuse and addiction. Neurobiology of eating disorders. Neurobiology of personality disorders. Neurobiology of childhood disorders. Part IV: Psychopharmacological Treatment. Treatment of depression. Treatment of bipolar disorder. Treatment of schizophrenia. Treatment of anxiety disorders. Treatment of agitation and aggression in the elderly. Treatment of substance-related disorders. Treatment of eating disorders. Treatment of insomnia. Treatment of personality disorders. Treatment of psychiatric emergencies. Treatment of childhood and adolescent disorders. Psychopharmacology during pregnancy and lactation. Treatment during late life. Treatment of chronic pain syndromes. Part V: Ethical Issues. Ethical considerations in psychopharmacological treatment and research. Index.