As the leading cause of adult disability, stroke poses substantial economic and psychological burdens to populations around the world. Against this dismal backdrop, several novel "neurorestorative" approaches are being investigated as adjunctive treatments to physiotherapy. Stroke Recovery with Cellular Therapies discusses the promising investigations around the world on cell-based therapies to enhance recovery from stroke. Throughout this groundbreaking text, chapters detail the potential benefits of various types of cells and approaches for ischemic and hemorrhagic stroke, and all studies rely upon traditional histological and functional outcomes. Among the topics detailed in this volume are transplanting immortalized neural stem cells, transplantation of bone marrow stromal cells, adipose-derived stem cells, endogenous neural stem cells in tissue remodeling, and an investigation into the ethics of stem cell research. This text provides an overview of the field, stimulates ideas for further research, and will help serve as a foundation for cell-based therapies to move forward as a viable approach for stroke recovery in the future.

Table of Contents:

Chapter 1: Introduction

The Potential of Cell Transplantation to Enhance Recovery After Stroke

Sean I. Savitz, MD

Assistant Professor of Neurology

Harvard Medical School

Boston, MA 02215


Chapter 2

Safety and Efficacy of Transplanting Immortalized Neural Stem Cells in Stroke Patients

Lawrence Wechsler, MD

Professor of Neurology

University of Pittsburgh Medical School


Chapter 3

Bone Marrow Transplantation Therapy for Stroke Recovery

Michael Chopp, PhD

Professor and Vice-Chairman

Department of Neurology

Henry Ford Health Sciences Center

Detroit, MI


Chapter 4

Human Umbilical Cord Cells for Stroke Recovery

Alison Wiling, PhD

Assistant Professor of Neurosurgery

Director, Center of Excellence for Aging & Brain Repair

University of South Florida College of Medicine




Chapter 5

Potential of Adipose-derived Stem Cells for Stroke

Henry Rice, MD

Associate Professor of Surgery

Duke University Medical Center

Chapter 6

Novel Imaging Modalities to Monitor Implanted Embryonic Stem Cells in Stroke

Mathias Hoehn, PhD

Max Planck Institute for Neurological Research

Cologne, Germany

Chapter 7

Cell Transplantation for Intracerebral Hemorrhage

JK Roh, MD

Professor of Neurology

Seoul National University Hospital

Korea
Chapter 8

Induction Neurogenesis To Repair The Brain: Do We Need Exogenous Cell Transplantation

Mark Mehler, MD

Professor of Neurology and Neuroscience

Albert Einstein College of Medicine

Chapter 9

Ethics of Stem Cell Transplantation

Ruth Macklin, PhD

Professor of Bioethics

Department of Epidemiology

Albert Einstein College of Medicine

Chapter 10

Special Considerations in Clinical Trial Design for Stroke Transplantation

Sean I Savitz MD and Louis Caplan, MD
Assistant Professor of Neurology and Professor of Neurology

Harvard Medical School

Beth Israel Deaconess Medical Center