Here's the completely revised, updated, and streamlined 5th Edition of the acclaimed reference on infectious diseases in children. The new edition reflects all of today's significant changes and advances in the treatment of paediatric infectious disease-providing readers with the most complete information on the full range of diseases. It offers unparalleled coverage of immunology, epidemiology, public health, preventive medicine, clinical manifestations, diagnosis, treatment and much more.

This book is available at a special introductory price until three months after publication.

What's New

Includes separate chapters for infections in children with bone marrow, heart, liver and kidney transplantations
Offers full-chapter coverage of infections related to prosthetic or artificial devices central line infections mechanisms of emerging microbial resistance antibiotic dosing and renal or hepatic failure and drug interactions of antibiotics and outpatient intravenous antibiotic therapy
Discusses infections related to plastic surgery procedures, including complex craniotomy procedures and skin grafts
Presents expanded discussions of the treatment of sinusitius post-operative median sternotomy infections treatment and the duration of therapy for brain abscess Candida renal abscess in the neonate chronic osteomyelitis infections related to arthroscopy duration of therapy for invasive aspergillus and travel medicine
Includes a new section on perinatal or natal transmission of hepatitis C, plus a completely new chapter on hepatitis G
Offers new coverage of the treatment options for ruptured or complicated appendicitis hepato-splenic "cat scratch" fever periodic fever with ulcer pharyngitis adenitis chronic fatigue syndrome and hemophagocytic syndrome

Contents

PART I-HOST PARASITE RELATIONSHIPS AND
THE PATHOGENESIS OF INFECTIOUS DISEASES

1. MICROBIAL VIRULENCE FACTORS
2. IMMUNOLOGIC AND PHAGOCYTIC RESPONSES TO INFECTIONS
3. METABOLIC RESPONSE OF THE HOST TO INFECTIONS
4. INTERACTION OF INFECTION AND NUTRITION
5. FEVER: PATHOGENESIS AND TREATMENT
6. INDIGENOUS FLORA
7. EPIDEMIOLOGY OF INFECTIOUS DISEASES

PART II - INFECTION OF SPECIFIC ORGAN SYSTEMS

SECTION ONE - UPPER RESPIRATORY TRACT INFECTIONS
8. THE COMMON COLD
9. INFECTIONS OF THE ORAL CAVITY
10. PHARYNGITIS (PHARYNGITIS, TONSILLITIS, TONSILLOPHARYNGITIS, AND NASOPHARYNGITIS)
11. HERPANGINA
12. PHARYNGOCONJUNCTIVAL FEVER
13. UVULITIS
14. PERITONSILLAR, RETROPHARYNGEAL, AND PARAPHARYNGEAL ABSCESSES
15. CERVICAL LYMPHADENITIS
16. PAROTITIS
17. SINUSITIS
18. OTITIS EXTERNA
19. OTITIS MEDIA
20. MASTOIDITIS
21. EPIGLOTTITIS (SUPRAGLOTTITIS)
22. CROUP (LARYNGITIS, LARYNGOTRACHEITIS, SPASMODIC CROUP,
LARYNGOTRACHEOBRONCHITIS, BACTERIAL TRACHEITIS, AND LARYNGOTRACHEOBRONCHOPNEUMONITIS)

SECTION TWO - LOWER RESPIRATORY TRACT INFECTIONS
23. ACUTE BRONCHITIS
24. CHRONIC BRONCHITIS
25. BRONCHIOLITIS AND INFECTIOUS ASTHMA
26. NONBACTERIAL PNEUMONIA
27. BACTERIAL PNEUMONIAS
28. CHRONIC INTERSTITIAL PNEUMONITIS AND HYPERSENSITIVITY PNEUMONITIS
29. PLEURAL EFFUSIONS AND EMPYEMA
30. LUNG ABSCESS
31. CYSTIC FIBROSIS

SECTION THREE - INFECTIONS OF THE HEART
32. INFECTIVE ENDOCARDITIS
33. INFECTIOUS PERICARDITIS
34. MYOCARDITIS
35. ACUTE RHEUMATIC FEVER
36. NONINFECTIOUS CARDITIS
37. MEDIASTINITIS

SECTION FOUR - CENTRAL NERVOUS SYSTEM INFECTIONS
38. BACTERIAL MENINGITIS BEYOND THE NEONATAL PERIOD

39. PARAMENINGEAL INFECTIONS
40. FUNGAL MENINGITIS
41. EOSINOPHILIC MENINGITIS
42. ASEPTIC MENINGITIS AND VIRAL MENINGITIS
43. ENCEPHALITIS AND MENINGOENCEPHALITIS
44. TRANSVERSE MYELITIS OR MYELOPATHY
45. GUILLAIN-BARRÉ SYNDROME

SECTION FIVE - GENITOURINARY TRACT INFECTIONS
46. GENITOURINARY TRACT INFECTIONS
a. Urethritis
b. Cystitis and Pyelonephritis
47. RENAL ABSCESS
48. PROSTATITIS
49. SEXUALLY TRANSMITTED DISEASES AND OTHER GENTIAL INFECTIONS

SECTION SIX - GASTROINTESTINAL TRACT INFECTIONS
50. ESOPHAGITIS
51. APPROACH TO PATIENTS WITH GASTROINTESTINAL TRACT INFECTIONS AND FOOD POISONING
52. ANTIBIOTIC-ASSOCIATED COLITIS
53. WHIPPLE DISEASE

SECTION SEVEN - LIVER DISEASES
54. VIRAL HEPATITIS
55. CHOLANGITIS AND CHOLECYSTITIS
56. PYOGENIC LIVER ABSCESS
57. REYE SYNDROME

SECTION EIGHT - OTHER INTRA-ABDOMINAL INFECTIONS
58. APPENDICITIS AND PELVIC ABSCESS
59. PANCREATITIS
60. PERITONITIS AND INTRA-ABDOMINAL ABSCESS
61. RETROPERITONEAL INFECTIONS

SECTION NINE - MUSCULOSKELETAL INFECTIONS
62. OSTEOMYELITIS AND SEPTIC ARTHRITIS
63. BACTERIAL MYOSITIS AND PYOMYOSITIS
64. MISCELLANEOUS CAUSES OF MYOSITIS

SECTION TEN - SKIN INFECTIONS
65. CUTANEOUS MANIFESTATIONS OF SYSTEMIC INFECTIONS
66. ROSEOLA INFANTUM (EXANTHEM SUBITUM)
67. PRIMARY SKIN INFECTIONS

SECTION ELEVEN - OCULAR INFECTIONS
68. OCULAR INFECTIOUS DISEASES

SECTION TWELVE - SYSTEMIC INFECTIOUS DISEASES
69. BACTEREMIA AND SEPTIC SHOCK
70. FEVER WITHOUT SOURCE AND FEVER OF UNKNOWN ORIGIN
71. TOXIC SHOCK SYNDROME
72. ADULT RESPIRATORY DISTRESS SYNDROME IN CHILDREN

SECTION THIRTEEN - INFECTIONS OF THE FETUS AND NEWBORN
73. VIRAL INFECTIONS OF THE FETUS AND NEONATE
74. PERINATAL BACTERIAL DISEASES

SECTION FOURTEEN - INFECTIONS OF THE COMPROMISED HOST
75. PRIMARY IMMUNODEFICIENCIES
76. OPPORTUNISTIC INFECTIONS IN CHILDREN WITH BONE MARROW TRANSPLANTATION
77. INFECTION INPEDIATRIC HEART TRANSPLANT RECIPIENTS
78. OPPORTUNTIC INFECTIONS IN CHILDREN WITH BONE MARROW TRANSPLANTATION
79. OPPRTUNISTIC INFECTIONS IN CHILDREN WITH KIDNEY TRANSPLANTATION
80. INFECTIONS REALATION TO PROSTHETIC OR ARTIFICAL DEVICES
81. INFECTIONS RELATED TO CRANIOFACIAL SURGICAL PROCEDURES

SECTION FIFTEEN-UNCLASSIFIED INFECTIOUS DISEASES
82. KAWASAKI DISEASE
83. CHRONIC FATIGUE SYNDROME

PART III - INFECTIONS WITH SPECIFIC MICROORGANISMS

SECTION SIXTEEN - BACTERIAL INFECTIONS
84. NOMENCLATURE OF AEROBIC AND ANAEROBIC BACTERIA

SUBSECTION ONE - GRAM-POSITIVE COCCI
85. COAGULASE-POSITIVE STAPHYLOCOCCAL INFECTIONS
86. COAGULASE-NEGATIVE STAPHYLOCOCCAL INFECTIONS
87. GROUP A, GROUP C, AND GROUP G BETA-HEMOLYTIC STREPTOCOCCAL INFECTIONS
88. GROUP B STREPTOCOCCAL INFECTIONS
89. ENTEROCOCCAL AND VIRIDANS STREPTOCOCCAL INFECTIONS
90. PNEUMOCOCCAL INFECTIONS
91. MISCELLANEOUS GRAM-POSITIVE COCCI

SUBSECTION TWO - GRAM-NEGATIVE COCCI
92. MORAXELLA CATARRHALIS
93. MENINGOCOCCAL DISEASE
94. GONOCOCCAL DISEASE

SUBSECTION THREE - GRAM-POSITIVE BACILLI
95. DIPHTHERIA
96. ANTHRAX
97. BACILLUS CEREUS
98. ARCANOBACTERIUM HAEMOLYTICUM
99. ERYSIPELOTHRIX RHUSIOPATHIAE
100. LISTERIOSIS
101. TUBERCULOSIS
102. OTHER MYCOBACTERIA
103. LEPROSY AND BURULI ULCER: THE MAJOR CUTANEOUS MYCOBACTERIOSES
104. NOCARDIA
105. MISCELLANEOUS GRAM-POSITIVE BACILLI

SUBSECTION FOUR - ENTEROBACTERIA
106. CITROBACTER
107. ENTEROBACTER
108. DIARRHEA- AND DYSENTERY-CAUSING ESCHERICHIA COLI
109. KLEBSIELLA
110. MORGANELLA MORGANII
111. PROTEUS
112. PROVIDENCIA
113. SHIGELLA
114. SERRATIA
115. SALMONELLA
116. PLAGUE (YERSINIA PESTIS)
117. OTHER YERSINIA SPECIES
118. MISCELLANEOUS ENTEROBACTERIACEAE
119. AEROMONAS
120. PASTEURELLA MULTOCIDA
121. CHOLERA
122. VIBRIO PARAHAEMOLYTICUS
123. VIBRIO VULNIFICUS
124. MISCELLANEOUS NON-ENTEROBACTERIACEAE FERMENTATIVE BACILLI
125. ACINETOBACTER
126. ALCALIGENES
127. EIKENELLA CORRODENS
128. CHRYSEBACTERIUM (FLAVOBACTERIUM
129. PSEUDOMONAS AND RELATED SPECIES
130. STENOTROPHOMONAS (XANTHOMONAS) MALTOPHILIA

SUBSECTION FIVE - GRAM-NEGATIVE COCCOBACILLI
131. ACTINOBACILLUS ACTINOMYCETEMCOMITANS
132. BARTONELLOSIS
133. BRUCELLOSIS
134. PERTUSSIS AND OTHER BORDETELLA INFECTIONS
135. CALYMMATOBACTERIUM GRANULOMATIS
136. CAMPYLOBACTER JEJUNI
137. OTHER CAMPYLOBACTER SPECIES
138. TULAREMIA
139. HAEMOPHILUS INFLUENZAE
140. OTHER HAEMOPHILUS SPECIES
141. HELICOBACTER PYLORI
142. KINGELLA SPECIES
143. LEGIONNAIRES' DISEASE, PONTIAC FEVER, AND R ELATED ILLNESSES
144. STREPTOBACILLUS MONILIFORMIS (RAT BITE FEVER)
145. BARTONELLA: CAT-SCRATCH DISEASE

SUBSECTION SIX - TREPONEMATACEAE
146. BORRELIA (RELAPSING FEVER)
147. BORRELIA (LYME DISEASE)
148. LEPTOSPIROSIS
149. SPIRILLUM MINUS (RAT BITE FEVER)
150. SYPHILIS
151. NONVENEREAL TREPONEMATOSES

SUBSECTION SEVEN - ANAEROBIC BACTERIA
152. CLOSTRIDIAL INTOXICATION AND INFECTION
153. INFANT BOTULISM
154. TETANUS
155. ACTINOMYCOSIS
156. OTHER ANAEROBIC INFECTIONS

SECTION SEVENTEEN - VIRAL INFECTIONS
157. CLASSIFICATION AND NOMENCLATURE OF VIRUSES

DNA VIRUSES

SUBSECTION ONE - PARVOVIRIDAE
158. HUMAN PARVOVIRUS B19

SUBSECTION TWO - PAPILLOVIRIDAE
159. PAPILLOMAVIRUSES

SUBSECTION THREE - MISCELLANEOUS SLOW VIRUSES AND PRION-RELATED DISEASES
160. TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES (Creutzfeld-Jakob Disease, Gertsmann-Straussler-Scheinker Disease, Kuru, Fatal Familial Insomnia, new variant Creutzfeld-Jakob Disease)

SUBSECTION FOUR - ADENOVIRIDAE
161. ADENOVIRUSES

SUBSECTION FIVE - HEPATOVIRIDAE
162. HEPATITIS B and D VIRUSES

SUBSECTION SIX - HERPESVIRIDAE
163. HERPES SIMPLEX VIRUSES 1 and 2
164. CYTOMEGALOVIRUS
165. EPSTEIN-BARR VIRUS
166. HUMAN HERPESVIRUSES 6, 7, and 8
167. VARICELLA-ZOSTER VIRUS

SUBSECTION SEVEN - POXVIRIDAE
168. SMALLPOX (VARIOLA VIRUS)
169. OTHER POXVIRUSES

RNA VIRUSES
SUBSECTION ONE - PICORNAVIRIDAE
170. ENTEROVIRUSES: POLIOVIRUSES (POLIOMYELITIS, COXSACKIEVIRUSES, AND ENTEROVIRUSES)
171. RHINOVIRUSES
172. HEPATITIS A VIRUS

SUBSECTION TWO - CALICIVIRIDAE
173. CALICIVIRUSES

SUBSECTION THREE - REOVIRIDAE
174. REOVIRUSES
175. ORBIVIRUSES AND COLTIVIRUSES
176. ROTAVIRUSES

SUBSECTION FOUR - TOGAVIRIDAE
177. RUBELLA VIRUS
178. ALPHAVIRUSES
a. EASTERN EQUINE ENCEPHALITIS
b. WESTERN EQUINE ENCEPHALITIS
c. VENEZUELAN EQUINE ENCEPHALITIS
d. CHIKUNGUNYA
e. ROSS RIVER VIRUS ARTHRITIS
f. OTHER ALPHAVIRAL INFECTIONS

SUBSECTION FIVE - FLAVIVIRIDAE
179. FLAVIVIRUSES
a. ST. LOUIS ENCEPHALITIS
b. YELLOW FEVER
c. DENGUE AND DENGUE HEMORRHAGIC FEVER
d. JAPANESE ENCEPHALITIS
e. MURRAY VALLEY ENCEPHALITIS
f. TICK-BORNE ENCEPHALITIS
g. OTHER FLAVIVIRAL INFECTIONS
180. HEPATITIS C VIRUS

SUBSECTION SIX - ORTHOMYXOVIRIDAE
181. INFLUENZA VIRUSES

SUBSECTION SEVEN - PARAMYXOVIRIDAE
182. PARAINFLUENZA VIRUSES
183. MEASLES VIRUS
184. MUMPS VIRUS
185. RESPIRATORY SYNCYTIAL VIRUS

SUBSECTION EIGHT - RHABDOVIRIDAE
186. RABIES VIRUS

SUBSECTION NINE - FILOVIRIDAE
187. ARENAVIRAL HEMORRHAGIC FEVERS
188. FILOVIRAL HEMORRAGIC FEVERS: MARBURG AND EBOLA VIRUS FEVERS

SUBSECTION TEN - CORONAVIRIDAE
189. CORONAVIRUSES AND TOROVIRUSES

SUBSECTION ELEVEN - BUNYAVIRIDAE
190. HANTAVIRUSES
191. LA CROSSE ENCEPHALITIS AND OTHER CALIFORNIA SEROGROUP VIRUSES
192. OTHER BUNYAVIRIDAE
a. RIFT VALLEY FEVER
b. CRIMEAN-CONGO HEMORRHAGIC FEVER
c. PHLEBOTOMUS FEVER (SANDFLY FEVER)
d. OROPOUCHE FEVER

SUBSECTION TWELVE - RETROVIRIDAE
193. HUMAN RETROVIRUSES

SECTION EIGHTEEN - CHLAMYDIA
194. CHLAMYDIA INFECTIONS

SECTION NINETEEN - RICKETTSIAL DISEASES
195. RICKETTSIAL DISEASES

SECTION TWENTY - MYCOPLASMA
196. MYCOPLASMA AND UREAPLASMA INFECTIONS

SECTION TWENTY-ONE - FUNGAL DISEASES
197. CLASSIFICATION OF FUNGI
198. ASPERGILLUS INFECTIONS
199. BLASTOMYCOSIS
200. CANDIDIASIS
201. COCCIDIOIDOMYCOSIS
202. PARACOCCIDIOIDOMYCOSIS
203. CRYPTOCOCCOSIS
204. HISTOPLASMOSIS
205. SPOROTRICHOSIS
206. ZYGOMYCOSIS
207. MISCELLANEOUS MYCOSES

SECTION TWENTY-TWO - PARASITIC DISEASES
208. CLASSIFICATION/NOMENCLATURE OF HUMAN PARASITES

SUBSECTION ONE - PROTOZOA
A. AMOEBA
209. AMEBIASIS
210. BLASTOCYSTIS HOMINIS INFECTION
211. ENTAMOEBA COLI INFECTION

B. FLAGELLATES (INTESTINAL)
212. GIARDIASIS
213. DIENTAMOEBA FRAGILIS INFECTIONS
214. TRICHOMONAS INFECTIONS

C. CILIATES (INTESTINAL)
215. BALANTIDIUM COLI

D. COCCIDIA, INICNOSPORIDIA (INTESTINAL)
216. CRYPTOSPORIDIOSIS, CYCLOSPORA INFECTION, ISOSPORIASIS,and MICROSPORIDIOSIS

E. SPORAZIN, FLAGELLATES
217. BABESIOSIS
218. MALARIA
219. LEISHMANIASIS
220. TRYPANOSOMIASIS
221. NAEGLERIA, ACANTHAMOEBA, AND BALAMUTHIA
222. TOXOPLASMOSIS
223. PNEUMOCYSTIS CARINII PNEUMONIA

SUBSECTION TWO - NEMATODES
224. PARASITIC NEMATODE INFECTIONS

SUBSECTION THREE - CESTODES
225. CESTODES

SUBSECTION FOUR - TREMATODES
226. TREMATODES
227. SCHISTOSOMIASIS

SUBSECTION FIVE - ARTHROPODS
228. ARTHROPODS

SECTION TWENTY-THREE - HEALTH INFORMATION FOR INTERNATIONAL TRAVEL 229. INTERNATIONAL TRAVEL ISSUES FOR CHILDREN
230. INFECTIOUS DISEASE PROBLEMS OF INTERNATIONAL ADOPTEES REFUGEES

PART IV - INFECTION CONTROL

SECTION TWENTY-FOUR - HOSPITAL CONTROL OF INFECTIONS
231. NOSOCOMIAL INFECTIONS
232. PREVENTION AND CONTROL OF INFECTIONS IN HOSPITALIZED CHILDREN

PART V - THERAPEUTICS

233. MECHANISMS OF ANTIBACTERIAL AND ANTIVIRAL RESISTANCE
234. PHARMACOLOGY AND PHARMAKINETICS OF INFECTIOUS AGENTS
235. ANTIBACTERIAL THERAPEUTIC AGENTS
236. ANTIMICROBIAL PROPHYLAXIS
237. OUTPATIENT INTRAVENOUS ANTIBIOTIC THERAPY OF SERIOUS INFECTIONS
238. ANTIVIRAL AGENTS
239. ANTIFUNGAL AGENTS
240. DRUGS FOR PARASITIC DISEASES
241. IMMUNOMODULATING AGENTS

PART VI - PREVENTION OF INFECTIOUS DISEASES
242. ACTIVE IMMUNIZING AGENTS
243. PASSIVE IMMUNIZATION

SECTION TWENTY-FIVE - OTHER PREVENTIVE CONSIDERATIONS
244. PUBLIC HEALTH CONSIDERATIONS
245. INFECTIONS IN DAY CARE ENVIRONMENTS
246. HUMAN AND ANIMAL BITES
247. BIOTERRISM

PART VII - GUIDES TO THE DIAGNOSIS OF INFECTION
248. USE OF THE BACTERIOLOGY, MYCOLOGY, AND PARASITOLOGY LABORATORIES
249. USE OF THE DIAGNOSTIC VIROLOGY LABORATORY
250. USE OF THE SEROLOGY LABORATORY

PART VIII - BIOSTATISTICS APPLICABLE TO THE SUBSPECIALTY OF INFECTIOUS DISEASES
251. EPIDEMIOLOGY AND BIOSTATISTICS